ADAM12 — 126 ClinVar variants
All ClinVar germline ADAM12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
6 Benign · 10 Likely benign · 110 Uncertain significance
Full ADAM12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 82
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM12 p.Ala11Thr Uncertain significance Single submitter
- ADAM12 p.Ala17Ser Uncertain significance Single submitter
- ADAM12 p.Ala24Thr Uncertain significance Single submitter
- ADAM12 p.Ala324Gly Uncertain significance Single submitter
- ADAM12 p.Ala39Thr Uncertain significance Single submitter
- ADAM12 p.Ala478Gly Uncertain significance Single submitter
- ADAM12 p.Ala478Val Uncertain significance Single submitter
- ADAM12 p.Ala595Gly Uncertain significance Single submitter
- ADAM12 p.Ala822Ser Uncertain significance Single submitter
- ADAM12 p.Ala869Val Uncertain significance Single submitter
- ADAM12 p.Ala903Thr Uncertain significance Single submitter
- ADAM12 p.Arg160Ser Uncertain significance Single submitter
- ADAM12 p.Arg200Gly Uncertain significance Single submitter
- ADAM12 p.Arg255Trp Uncertain significance Single submitter
- ADAM12 p.Arg446His Uncertain significance Single submitter
- ADAM12 p.Arg480Gly Uncertain significance Single submitter
- ADAM12 p.Arg699Gln Uncertain significance Single submitter
- ADAM12 p.Arg733Gln Uncertain significance Single submitter
- ADAM12 p.Arg750Cys Uncertain significance Single submitter
- ADAM12 p.Arg753Gln Uncertain significance Single submitter
- ADAM12 p.Arg756Cys Uncertain significance Single submitter
- ADAM12 p.Arg756His Uncertain significance Single submitter
- ADAM12 p.Arg788Ile Uncertain significance Single submitter
- ADAM12 p.Arg814Gln Uncertain significance Single submitter
- ADAM12 p.Arg882Leu Uncertain significance Single submitter
- ADAM12 p.Asn189His Uncertain significance Single submitter
- ADAM12 p.Asn550Ser Uncertain significance Single submitter
- ADAM12 p.Asp266Asn Uncertain significance Single submitter
- ADAM12 p.Asp266Val Uncertain significance Single submitter
- ADAM12 p.Asp396Ala Uncertain significance Single submitter
- ADAM12 p.Asp507Asn Uncertain significance Single submitter
- ADAM12 p.Asp60Asn Uncertain significance Single submitter
- ADAM12 p.Asp60Tyr Uncertain significance Single submitter
- ADAM12 p.Cys270Tyr Uncertain significance Single submitter
- ADAM12 p.Cys582Arg Uncertain significance Single submitter
- ADAM12 p.Cys792Arg Uncertain significance Single submitter
- ADAM12 p.Gln274His Uncertain significance Single submitter
- ADAM12 p.Gln793Arg Uncertain significance Single submitter
- ADAM12 p.Glu232Gly Uncertain significance Single submitter
- ADAM12 p.Glu398Asp Uncertain significance Single submitter
- ADAM12 p.Glu656Lys Uncertain significance Single submitter
- ADAM12 p.Glu87Asp Uncertain significance Single submitter
- ADAM12 p.Gly425Arg Uncertain significance Single submitter
- ADAM12 p.Gly705Ser Uncertain significance Single submitter
- ADAM12 p.Gly803Ser Uncertain significance Single submitter
- ADAM12 p.His463Asp Uncertain significance Single submitter
- ADAM12 p.His463Tyr Uncertain significance Single submitter
- ADAM12 p.Ile318Val Uncertain significance Single submitter
- ADAM12 p.Leu207Arg Uncertain significance Single submitter
- ADAM12 p.Leu215Val Uncertain significance Single submitter
- ADAM12 p.Leu886Val Uncertain significance Single submitter
- ADAM12 p.Leu89Phe Uncertain significance Single submitter
- ADAM12 p.Lys170Asn Uncertain significance Single submitter
- ADAM12 p.Lys729Asn Uncertain significance Single submitter
- ADAM12 p.Lys739Glu Uncertain significance Single submitter
- ADAM12 p.Lys77Glu Uncertain significance Single submitter
- ADAM12 p.Met659Thr Uncertain significance Single submitter
- ADAM12 p.Met773Lys Uncertain significance Single submitter
- ADAM12 p.Pro776Leu Uncertain significance Single submitter
- ADAM12 p.Pro781Ser Uncertain significance Single submitter
- ADAM12 p.Pro832His Uncertain significance Single submitter
- ADAM12 p.Pro832Leu Uncertain significance Single submitter
- ADAM12 p.Pro856Arg Uncertain significance Single submitter
- ADAM12 p.Ser365Gly Uncertain significance Single submitter
- ADAM12 p.Ser44Gly Uncertain significance Single submitter
- ADAM12 p.Ser827Gly Uncertain significance Single submitter
- ADAM12 p.Ser93Arg Uncertain significance Single submitter
- ADAM12 p.Ser93Thr Uncertain significance Single submitter
- ADAM12 p.Thr206Asn Uncertain significance Single submitter
- ADAM12 p.Thr323Met Uncertain significance Single submitter
- ADAM12 p.Thr477Ile Uncertain significance Single submitter
- ADAM12 p.Thr615Ala Uncertain significance Single submitter
- ADAM12 p.Thr693Arg Uncertain significance Single submitter
- ADAM12 p.Thr707Ile Uncertain significance Single submitter
- ADAM12 p.Thr902Ser Uncertain significance Single submitter
- ADAM12 p.Val218Met Uncertain significance Single submitter
- ADAM12 p.Val261Met Uncertain significance Single submitter
- ADAM12 p.Val263Leu Uncertain significance Single submitter
- ADAM12 p.Val407Leu Uncertain significance Single submitter
- ADAM12 p.Val723Met Uncertain significance Single submitter
- ADAM12 p.Val795Ala Uncertain significance Single submitter
- ADAM12 p.Val828Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- ADAM12 p.Ala459Thr Uncertain significance Single submitter
- ADAM12 p.Ala462Thr Uncertain significance Single submitter
- ADAM12 p.Arg446Cys Uncertain significance Single submitter
- ADAM12 p.Arg588Gln Uncertain significance Single submitter
- ADAM12 p.Asn520Ser Uncertain significance Single submitter
- ADAM12 p.Asp285Ala Uncertain significance Single submitter
- ADAM12 p.Asp285Gly Uncertain significance Single submitter
- ADAM12 p.Cys176Tyr Uncertain significance Single submitter
- ADAM12 p.Glu527Lys Uncertain significance Single submitter
- ADAM12 p.Glu571Lys Uncertain significance Single submitter
- ADAM12 p.Gly103Ser Uncertain significance Single submitter
- ADAM12 p.Gly382Arg Uncertain significance Single submitter
- ADAM12 p.Gly420Arg Uncertain significance Single submitter
- ADAM12 p.Gly663Ser Uncertain significance Single submitter
- ADAM12 p.Gly721Arg Uncertain significance Single submitter
- ADAM12 p.Phe277Leu Uncertain significance Single submitter
- ADAM12 p.Pro440Thr Uncertain significance Single submitter
- ADAM12 p.Ser496Thr Uncertain significance Single submitter
- ADAM12 p.Ser563Leu Uncertain significance Single submitter
- ADAM12 p.Thr104Ile Uncertain significance Single submitter
- ADAM12 p.Tyr618His Uncertain significance Single submitter
- ADAM12 p.Val666Leu Uncertain significance Single submitter
All ADAM12 variants
Benign 6
- c.2105-7G>C Multiple submitters
- p.Gly771= Multiple submitters
- p.Lys770= Multiple submitters
- p.His119= Single submitter
- p.Lys167Arg Single submitter
- p.Met659Val Single submitter
Likely benign 10
- p.Asp515= Multiple submitters
- p.Ala109Thr Single submitter
- p.Ala166Val Single submitter
- p.Ala186Thr Single submitter
- p.Ala869= Single submitter
- p.Arg173Trp Single submitter
- p.Arg821Gln Single submitter
- p.Gln422Arg Single submitter
- p.Gln645Arg Single submitter
- p.Thr879Ser Single submitter
Uncertain significance 110
- p.Ala11Thr Single submitter ⚠
- p.Ala17Ser Single submitter ⚠
- p.Ala24Thr Single submitter ⚠
- p.Ala324Gly Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Ala459Thr Single submitter ⚠
- p.Ala462Thr Single submitter ⚠
- p.Ala478Gly Single submitter ⚠
- p.Ala478Val Single submitter ⚠
- p.Ala552Thr Single submitter
- p.Ala595Gly Single submitter ⚠
- p.Ala822Ser Single submitter ⚠
- p.Ala869Val Single submitter ⚠
- p.Ala903Thr Single submitter ⚠
- p.Arg160Ser Single submitter ⚠
- p.Arg200Gly Single submitter ⚠
- p.Arg255Trp Single submitter ⚠
- p.Arg446Cys Single submitter ⚠
- p.Arg446His Single submitter ⚠
- p.Arg480Gly Single submitter ⚠
- p.Arg588Gln Single submitter ⚠
- p.Arg699Gln Single submitter ⚠
- p.Arg733Gln Single submitter ⚠
- p.Arg750Cys Single submitter ⚠
- p.Arg753Gln Single submitter ⚠
- p.Arg756Cys Single submitter ⚠
- p.Arg756His Single submitter ⚠
- p.Arg788Ile Single submitter ⚠
- p.Arg814Gln Single submitter ⚠
- p.Arg882Leu Single submitter ⚠
- p.Asn189His Single submitter ⚠
- p.Asn520Ser Single submitter ⚠
- p.Asn550Ser Single submitter ⚠
- p.Asp230Glu Single submitter
- p.Asp266Asn Single submitter ⚠
- p.Asp266Val Single submitter ⚠
- p.Asp285Ala Single submitter ⚠
- p.Asp285Gly Single submitter ⚠
- p.Asp396Ala Single submitter ⚠
- p.Asp507Asn Single submitter ⚠
- p.Asp60Asn Single submitter ⚠
- p.Asp60Tyr Single submitter ⚠
- p.Cys176Tyr Single submitter ⚠
- p.Cys270Tyr Single submitter ⚠
- p.Cys582Arg Single submitter ⚠
- p.Cys792Arg Single submitter ⚠
- p.Gln274His Single submitter ⚠
- p.Gln793Arg Single submitter ⚠
- p.Glu232Gly Single submitter ⚠
- p.Glu398Asp Single submitter ⚠
- p.Glu527Lys Single submitter ⚠
- p.Glu571Lys Single submitter ⚠
- p.Glu656Lys Single submitter ⚠
- p.Glu87Asp Single submitter ⚠
- p.Gly103Ser Single submitter ⚠
- p.Gly382Arg Single submitter ⚠
- p.Gly420Arg Single submitter ⚠
- p.Gly425Arg Single submitter ⚠
- p.Gly620Ser Single submitter
- p.Gly663Ser Single submitter ⚠
- p.Gly705Ser Single submitter ⚠
- p.Gly721Arg Single submitter ⚠
- p.Gly803Ser Single submitter ⚠
- p.His463Asp Single submitter ⚠
- p.His463Tyr Single submitter ⚠
- p.Ile318Val Single submitter ⚠
- p.Ile591Thr Single submitter
- p.Leu207Arg Single submitter ⚠
- p.Leu215Val Single submitter ⚠
- p.Leu886Val Single submitter ⚠
- p.Leu89Phe Single submitter ⚠
- p.Lys170Asn Single submitter ⚠
- p.Lys729Asn Single submitter ⚠
- p.Lys739Glu Single submitter ⚠
- p.Lys77Glu Single submitter ⚠
- p.Met659Thr Single submitter ⚠
- p.Met773Lys Single submitter ⚠
- p.Phe277Leu Single submitter ⚠
- p.Pro317Ala Single submitter
- p.Pro440Thr Single submitter ⚠
- p.Pro776Leu Single submitter ⚠
- p.Pro781Ser Single submitter ⚠
- p.Pro832His Single submitter ⚠
- p.Pro832Leu Single submitter ⚠
- p.Pro856Arg Single submitter ⚠
- p.Ser365Gly Single submitter ⚠
- p.Ser44Gly Single submitter ⚠
- p.Ser496Thr Single submitter ⚠
- p.Ser563Leu Single submitter ⚠
- p.Ser827Gly Single submitter ⚠
- p.Ser93Arg Single submitter ⚠
- p.Ser93Thr Single submitter ⚠
- p.Thr104Ile Single submitter ⚠
- p.Thr206Asn Single submitter ⚠
- p.Thr323Met Single submitter ⚠
- p.Thr477Ile Single submitter ⚠
- p.Thr615Ala Single submitter ⚠
- p.Thr693Arg Single submitter ⚠
- p.Thr707Ile Single submitter ⚠
- p.Thr902Ser Single submitter ⚠
- p.Tyr618His Single submitter ⚠
- p.Val213Met Single submitter
- p.Val218Met Single submitter ⚠
- p.Val261Met Single submitter ⚠
- p.Val263Leu Single submitter ⚠
- p.Val407Leu Single submitter ⚠
- p.Val666Leu Single submitter ⚠
- p.Val723Met Single submitter ⚠
- p.Val795Ala Single submitter ⚠
- p.Val828Ile Single submitter ⚠