ADAM15 — 147 ClinVar variants

All ClinVar germline ADAM15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 131 flagged for review →

2 Benign · 16 Likely benign · 129 Uncertain significance

Full ADAM15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 131

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 63

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 68

The independent predictors disagree with each other — read with care.

All ADAM15 variants

Benign 2

c.1918-6G>T Multiple submitters
p.Leu240Met Multiple submitters

Likely benign 16

p.Arg268His Multiple submitters ⚠
p.Ala813= Single submitter
p.Arg230Pro Single submitter
p.Arg396Gln Single submitter
p.Arg596Gln Single submitter
p.Arg645Gln Single submitter
p.Arg736= Single submitter
p.Asp103Asn Single submitter ⚠
p.Asp52Asn Single submitter
p.Cys612= Single submitter
p.Lys59Glu Single submitter
p.Pro275Ser Single submitter
p.Pro817= Single submitter
p.Val144Ile Single submitter ⚠
p.Val48Ile Single submitter
p.Pro431= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma

Uncertain significance 129

p.Ala221Asp Single submitter ⚠
p.Ala301Val Single submitter ⚠
p.Ala343Thr Single submitter ⚠
p.Ala347Ser Single submitter ⚠
p.Ala39Thr Single submitter ⚠
p.Ala4Thr Single submitter ⚠
p.Ala542Thr Single submitter ⚠
p.Ala543Val Single submitter ⚠
p.Ala556Asp Single submitter ⚠
p.Ala738Pro Single submitter ⚠
p.Ala768Val Single submitter ⚠
p.Ala813Val Single submitter ⚠
p.Arg106Gln Single submitter ⚠
p.Arg124Trp Single submitter ⚠
p.Arg149Lys Single submitter ⚠
p.Arg168Gln Single submitter ⚠
p.Arg184Trp Single submitter ⚠
p.Arg200Cys Single submitter ⚠
p.Arg204Trp Single submitter ⚠
p.Arg206Gln Single submitter ⚠
p.Arg238His Single submitter ⚠
p.Arg251Trp Single submitter ⚠
p.Arg268Cys Single submitter ⚠
p.Arg2Pro Single submitter ⚠
p.Arg396Leu Single submitter ⚠
p.Arg474Gly Single submitter ⚠
p.Arg553Trp Single submitter ⚠
p.Arg596Trp Single submitter ⚠
p.Arg718His Single submitter ⚠
p.Arg724Gln Single submitter ⚠
p.Arg756Gln Single submitter ⚠
p.Arg756Gly Single submitter ⚠
p.Arg782Gly Single submitter ⚠
p.Arg796His Single submitter ⚠
p.Arg796Pro Single submitter ⚠
p.Arg829Pro Single submitter ⚠
p.Arg94Cys Single submitter ⚠
p.Asn389Thr Single submitter ⚠
p.Asn555His Single submitter ⚠
p.Asn606Lys Single submitter ⚠
p.Asp496His Single submitter ⚠
p.Asp52His Single submitter ⚠
p.Asp575Tyr Single submitter ⚠
p.Asp604Val Single submitter ⚠
p.Asp834Glu Single submitter ⚠
p.Cys376Gly Single submitter ⚠
p.Cys424Arg Single submitter ⚠
p.Cys461Tyr Single submitter ⚠
p.Cys667Arg Single submitter ⚠
p.Cys675Arg Single submitter ⚠
p.Cys830Tyr Single submitter ⚠
p.Gln155Arg Single submitter ⚠
p.Gln479His Single submitter ⚠
p.Gln47His Single submitter ⚠
p.Gln530Arg Single submitter ⚠
p.Gln584His Single submitter ⚠
p.Gln625Pro Single submitter ⚠
p.Gln687Lys Single submitter ⚠
p.Glu110Ala Single submitter ⚠
p.Glu412Lys Single submitter ⚠
p.Glu42Lys Single submitter ⚠
p.Glu433Lys Single submitter ⚠
p.Gly111Glu Single submitter ⚠
p.Gly125Arg Single submitter ⚠
p.Gly13Ser Single submitter ⚠
p.Gly156Arg Single submitter ⚠
p.Gly15Arg Single submitter ⚠
p.Gly407Ala Single submitter ⚠
p.Gly432Asp Single submitter ⚠
p.Gly458Ala Single submitter ⚠
p.Gly458Val Single submitter ⚠
p.Gly515Arg Single submitter ⚠
p.Gly697Arg Single submitter ⚠
p.Gly77Ser Single submitter ⚠
p.His521Arg Single submitter ⚠
p.His80Tyr Single submitter ⚠
p.Ile26Lys Single submitter ⚠
p.Ile346Val Single submitter ⚠
p.Ile603Thr Single submitter ⚠
p.Ile71Thr Single submitter ⚠
p.Leu153Pro Single submitter ⚠
p.Leu172Pro Single submitter ⚠
p.Leu18Pro Single submitter ⚠
p.Leu402Ile Single submitter ⚠
p.Leu489Trp Single submitter ⚠
p.Leu534Pro Single submitter ⚠
p.Leu6Pro Single submitter ⚠
p.Leu725Phe Single submitter ⚠
p.Leu774Pro Single submitter ⚠
p.Leu863Ile Single submitter ⚠
p.Lys759Met Single submitter ⚠
p.Met316Ile Single submitter ⚠
p.Met316Leu Single submitter ⚠
p.Met333Val Single submitter ⚠
p.Met406Lys Single submitter ⚠
p.Met420Val Single submitter ⚠
p.Met427Val Single submitter ⚠
p.Phe423Ile Single submitter ⚠
p.Phe423Leu Single submitter ⚠
p.Pro193Ala Single submitter ⚠
p.Pro19Ser Single submitter ⚠
p.Pro297Leu Single submitter ⚠
p.Pro419Thr Single submitter ⚠
p.Pro475Leu Single submitter ⚠
p.Pro742Leu Single submitter ⚠
p.Pro749Leu Single submitter ⚠
p.Pro767Leu Single submitter ⚠
p.Pro770Arg Single submitter ⚠
p.Pro770His Single submitter ⚠
p.Pro770Thr Single submitter ⚠
p.Pro802Leu Single submitter ⚠
p.Pro836Arg Single submitter ⚠
p.Pro851Ser Single submitter ⚠
p.Ser336Pro Single submitter ⚠
p.Ser570Thr Single submitter ⚠
p.Ser765Ile Single submitter ⚠
p.Ser780Cys Single submitter ⚠
p.Thr113Ala Single submitter ⚠
p.Thr337Ile Single submitter ⚠
p.Thr629Pro Single submitter ⚠
p.Thr685Ile Single submitter ⚠
p.Tyr229Ser Single submitter ⚠
p.Val143Gly Single submitter ⚠
p.Val144Phe Single submitter ⚠
p.Val279Asp Single submitter ⚠
p.Val707Asp Single submitter ⚠
p.Val707Ile Single submitter ⚠
p.Val779Met Single submitter ⚠
p.Pro769= No assertion criteria