ADAM18 — 97 ClinVar variants
All ClinVar germline ADAM18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 90 flagged for review →
1 Conflicting · 9 Likely benign · 87 Uncertain significance
Full ADAM18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 90
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM18 p.Ala258Glu Uncertain significance Single submitter
- ADAM18 p.Ala340Thr Uncertain significance Single submitter
- ADAM18 p.Ala340Val Uncertain significance Single submitter
- ADAM18 p.Ala477Thr Uncertain significance Single submitter
- ADAM18 p.Ala6Thr Uncertain significance Single submitter
- ADAM18 p.Arg135Thr Uncertain significance Single submitter
- ADAM18 p.Arg261Trp Uncertain significance Single submitter
- ADAM18 p.Arg726Ser Uncertain significance Single submitter
- ADAM18 p.Asn103Asp Uncertain significance Single submitter
- ADAM18 p.Asn401Ser Uncertain significance Single submitter
- ADAM18 p.Asn594Asp Uncertain significance Single submitter
- ADAM18 p.Asn76Ser Uncertain significance Single submitter
- ADAM18 p.Cys360Phe Uncertain significance Single submitter
- ADAM18 p.Cys450Arg Uncertain significance Single submitter
- ADAM18 p.Cys464Arg Uncertain significance Single submitter
- ADAM18 p.Cys553Gly Uncertain significance Single submitter
- ADAM18 p.Cys642Ser Uncertain significance Single submitter
- ADAM18 p.Gln384Glu Uncertain significance Single submitter
- ADAM18 p.Gln574Arg Uncertain significance Single submitter
- ADAM18 p.Glu18Gln Uncertain significance Single submitter
- ADAM18 p.Glu526Ala Uncertain significance Single submitter
- ADAM18 p.Glu606Asp Uncertain significance Single submitter
- ADAM18 p.Gly640Ser Uncertain significance Single submitter
- ADAM18 p.His525Pro Uncertain significance Single submitter
- ADAM18 p.His557Arg Uncertain significance Single submitter
- ADAM18 p.His557Asp Uncertain significance Single submitter
- ADAM18 p.His684Tyr Uncertain significance Single submitter
- ADAM18 p.Ile110Met Uncertain significance Single submitter
- ADAM18 p.Ile110Val Uncertain significance Single submitter
- ADAM18 p.Ile140Val Uncertain significance Single submitter
- ADAM18 p.Ile188Val Uncertain significance Single submitter
- ADAM18 p.Ile211Val Uncertain significance Single submitter
- ADAM18 p.Ile243Thr Uncertain significance Single submitter
- ADAM18 p.Ile317Val Uncertain significance Single submitter
- ADAM18 p.Ile48Val Uncertain significance Single submitter
- ADAM18 p.Ile505Met Uncertain significance Single submitter
- ADAM18 p.Ile581Val Uncertain significance Single submitter
- ADAM18 p.Ile701Val Uncertain significance Single submitter
- ADAM18 p.Lys371Asn Uncertain significance Single submitter
- ADAM18 p.Lys375Asn Uncertain significance Single submitter
- ADAM18 p.Lys452Arg Uncertain significance Single submitter
- ADAM18 p.Met602Ile Uncertain significance Single submitter
- ADAM18 p.Phe506Tyr Uncertain significance Single submitter
- ADAM18 p.Pro148Thr Uncertain significance Single submitter
- ADAM18 p.Pro305Ser Uncertain significance Single submitter
- ADAM18 p.Pro435Ser Uncertain significance Single submitter
- ADAM18 p.Ser173Leu Uncertain significance Single submitter
- ADAM18 p.Ser246Arg Uncertain significance Single submitter
- ADAM18 p.Ser400Thr Uncertain significance Single submitter
- ADAM18 p.Ser563Ile Uncertain significance Single submitter
- ADAM18 p.Ser80Tyr Uncertain significance Single submitter
- ADAM18 p.Thr291Ala Uncertain significance Single submitter
- ADAM18 p.Thr487Ser Uncertain significance Single submitter
- ADAM18 p.Thr497Asn Uncertain significance Single submitter
- ADAM18 p.Trp259Arg Uncertain significance Single submitter
- ADAM18 p.Tyr157Asp Uncertain significance Single submitter
- ADAM18 p.Tyr367His Uncertain significance Single submitter
- ADAM18 p.Tyr87Asn Uncertain significance Single submitter
- ADAM18 p.Tyr87His Uncertain significance Single submitter
- ADAM18 p.Val155Ile Uncertain significance Single submitter
- ADAM18 p.Val169Phe Uncertain significance Single submitter
- ADAM18 p.Val569Ile Uncertain significance Single submitter
- ADAM18 p.Val737Met Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- ADAM18 p.Ala249Thr Uncertain significance Single submitter
- ADAM18 p.Arg255Ile Uncertain significance Single submitter
- ADAM18 p.Arg543Trp Uncertain significance Single submitter
- ADAM18 p.Arg726Cys Uncertain significance Single submitter
- ADAM18 p.Asn156Ser Uncertain significance Single submitter
- ADAM18 p.Asn465Ser Uncertain significance Single submitter
- ADAM18 p.Gln496Glu Uncertain significance Single submitter
- ADAM18 p.Glu128Lys Uncertain significance Single submitter
- ADAM18 p.Gly407Arg Uncertain significance Single submitter
- ADAM18 p.Gly407Ser Uncertain significance Single submitter
- ADAM18 p.Ile123Leu Likely benign Single submitter
- ADAM18 p.Ile211Thr Uncertain significance Single submitter
- ADAM18 p.Ile230Thr Likely benign Single submitter
- ADAM18 p.Leu443Val Uncertain significance Single submitter
- ADAM18 p.Leu691Met Uncertain significance Single submitter
- ADAM18 p.Leu8Phe Uncertain significance Single submitter
- ADAM18 p.Pro646Arg Uncertain significance Single submitter
- ADAM18 p.Ser151Tyr Uncertain significance Single submitter
- ADAM18 p.Ser314Leu Uncertain significance Single submitter
- ADAM18 p.Ser468Phe Uncertain significance Single submitter
- ADAM18 p.Thr28Pro Uncertain significance Single submitter
- ADAM18 p.Tyr304Ser Uncertain significance Single submitter
- ADAM18 p.Val106Met Uncertain significance Single submitter
- ADAM18 p.Val315Ile Uncertain significance Single submitter
- ADAM18 p.Val429Ile Uncertain significance Single submitter
- ADAM18 p.Val429Leu Uncertain significance Single submitter
All ADAM18 variants
Conflicting classifications of pathogenicity 1
- p.Met221Ile Single submitter ⚠
Likely benign 9
- p.Arg481His Single submitter
- p.Arg543Gln Single submitter
- p.Gln184= Single submitter
- p.Ile123Leu Single submitter ⚠
- p.Ile230Thr Single submitter ⚠
- p.Ile445Val Single submitter
- p.Ser400Pro Single submitter
- p.Thr627= Single submitter
- p.Val150Ile Single submitter
Uncertain significance 87
- p.Ala249Thr Single submitter ⚠
- p.Ala258Glu Single submitter ⚠
- p.Ala340Thr Single submitter ⚠
- p.Ala340Val Single submitter ⚠
- p.Ala477Thr Single submitter ⚠
- p.Ala6Thr Single submitter ⚠
- p.Arg135Thr Single submitter ⚠
- p.Arg255Ile Single submitter ⚠
- p.Arg261Trp Single submitter ⚠
- p.Arg543Trp Single submitter ⚠
- p.Arg726Cys Single submitter ⚠
- p.Arg726Ser Single submitter ⚠
- p.Asn103Asp Single submitter ⚠
- p.Asn156Ser Single submitter ⚠
- p.Asn401Ser Single submitter ⚠
- p.Asn465Ser Single submitter ⚠
- p.Asn594Asp Single submitter ⚠
- p.Asn76Ser Single submitter ⚠
- p.Cys360Phe Single submitter ⚠
- p.Cys450Arg Single submitter ⚠
- p.Cys464Arg Single submitter ⚠
- p.Cys553Gly Single submitter ⚠
- p.Cys642Ser Single submitter ⚠
- p.Gln384Glu Single submitter ⚠
- p.Gln496Glu Single submitter ⚠
- p.Gln574Arg Single submitter ⚠
- p.Glu128Lys Single submitter ⚠
- p.Glu18Gln Single submitter ⚠
- p.Glu526Ala Single submitter ⚠
- p.Glu606Asp Single submitter ⚠
- p.Gly407Arg Single submitter ⚠
- p.Gly407Ser Single submitter ⚠
- p.Gly640Ser Single submitter ⚠
- p.His525Pro Single submitter ⚠
- p.His557Arg Single submitter ⚠
- p.His557Asp Single submitter ⚠
- p.His684Tyr Single submitter ⚠
- p.Ile110Met Single submitter ⚠
- p.Ile110Val Single submitter ⚠
- p.Ile140Val Single submitter ⚠
- p.Ile188Val Single submitter ⚠
- p.Ile211Thr Single submitter ⚠
- p.Ile211Val Single submitter ⚠
- p.Ile243Thr Single submitter ⚠
- p.Ile317Val Single submitter ⚠
- p.Ile48Val Single submitter ⚠
- p.Ile505Met Single submitter ⚠
- p.Ile581Val Single submitter ⚠
- p.Ile701Val Single submitter ⚠
- p.Leu443Val Single submitter ⚠
- p.Leu691Met Single submitter ⚠
- p.Leu8Phe Single submitter ⚠
- p.Lys371Asn Single submitter ⚠
- p.Lys375Asn Single submitter ⚠
- p.Lys452Arg Single submitter ⚠
- p.Met602Ile Single submitter ⚠
- p.Phe506Tyr Single submitter ⚠
- p.Pro148Thr Single submitter ⚠
- p.Pro305Ser Single submitter ⚠
- p.Pro435Ser Single submitter ⚠
- p.Pro646Arg Single submitter ⚠
- p.Ser151Tyr Single submitter ⚠
- p.Ser173Leu Single submitter ⚠
- p.Ser246Arg Single submitter ⚠
- p.Ser314Leu Single submitter ⚠
- p.Ser400Thr Single submitter ⚠
- p.Ser468Phe Single submitter ⚠
- p.Ser563Ile Single submitter ⚠
- p.Ser80Tyr Single submitter ⚠
- p.Thr28Pro Single submitter ⚠
- p.Thr291Ala Single submitter ⚠
- p.Thr487Ser Single submitter ⚠
- p.Thr497Asn Single submitter ⚠
- p.Trp259Arg Single submitter ⚠
- p.Tyr157Asp Single submitter ⚠
- p.Tyr304Ser Single submitter ⚠
- p.Tyr367His Single submitter ⚠
- p.Tyr87Asn Single submitter ⚠
- p.Tyr87His Single submitter ⚠
- p.Val106Met Single submitter ⚠
- p.Val155Ile Single submitter ⚠
- p.Val169Phe Single submitter ⚠
- p.Val315Ile Single submitter ⚠
- p.Val429Ile Single submitter ⚠
- p.Val429Leu Single submitter ⚠
- p.Val569Ile Single submitter ⚠
- p.Val737Met Single submitter ⚠