ADAM19 — 137 ClinVar variants
All ClinVar germline ADAM19 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
8 Benign · 11 Likely benign · 118 Uncertain significance
Full ADAM19 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM19 p.Ala336Val Uncertain significance Single submitter
- ADAM19 p.Ala365Gly Uncertain significance Single submitter
- ADAM19 p.Ala365Val Uncertain significance Single submitter
- ADAM19 p.Ala815Gly Uncertain significance Single submitter
- ADAM19 p.Ala843Ser Uncertain significance Single submitter
- ADAM19 p.Ala843Thr Uncertain significance Single submitter
- ADAM19 p.Ala861Val Uncertain significance Single submitter
- ADAM19 p.Arg107Gln Uncertain significance Single submitter
- ADAM19 p.Arg107Trp Uncertain significance Single submitter
- ADAM19 p.Arg23Gln Uncertain significance Single submitter
- ADAM19 p.Arg417Gln Uncertain significance Single submitter
- ADAM19 p.Arg475Cys Uncertain significance Single submitter
- ADAM19 p.Arg751Thr Uncertain significance Single submitter
- ADAM19 p.Arg774Gln Uncertain significance Single submitter
- ADAM19 p.Arg784Gln Uncertain significance Single submitter
- ADAM19 p.Arg813Gly Uncertain significance Single submitter
- ADAM19 p.Arg854Gly Uncertain significance Single submitter
- ADAM19 p.Arg856Gln Uncertain significance Single submitter
- ADAM19 p.Asn144Ser Uncertain significance Single submitter
- ADAM19 p.Asn817Ile Uncertain significance Single submitter
- ADAM19 p.Asp393Gly Uncertain significance Single submitter
- ADAM19 p.Cys174Tyr Uncertain significance Single submitter
- ADAM19 p.Cys361Arg Uncertain significance Single submitter
- ADAM19 p.Cys540Trp Uncertain significance Single submitter
- ADAM19 p.Cys672Ser Uncertain significance Single submitter
- ADAM19 p.Cys748Phe Uncertain significance Single submitter
- ADAM19 p.Gln668His Uncertain significance Single submitter
- ADAM19 p.Gln754His Uncertain significance Single submitter
- ADAM19 p.Glu177Lys Uncertain significance Single submitter
- ADAM19 p.Gly117Ser Uncertain significance Single submitter
- ADAM19 p.Gly653Ala Uncertain significance Single submitter
- ADAM19 p.Gly759Ala Uncertain significance Single submitter
- ADAM19 p.Gly822Ala Uncertain significance Single submitter
- ADAM19 p.His265Arg Uncertain significance Single submitter
- ADAM19 p.His760Leu Uncertain significance Single submitter
- ADAM19 p.Leu160Phe Uncertain significance Single submitter
- ADAM19 p.Leu251Trp Uncertain significance Single submitter
- ADAM19 p.Leu539Phe Uncertain significance Single submitter
- ADAM19 p.Lys234Arg Uncertain significance Single submitter
- ADAM19 p.Lys246Glu Uncertain significance Single submitter
- ADAM19 p.Lys40Arg Uncertain significance Single submitter
- ADAM19 p.Lys901Glu Uncertain significance Single submitter
- ADAM19 p.Met304Val Uncertain significance Single submitter
- ADAM19 p.Met558Ile Uncertain significance Single submitter
- ADAM19 p.Met567Arg Uncertain significance Single submitter
- ADAM19 p.Phe176Leu Uncertain significance Single submitter
- ADAM19 p.Pro315Ala Uncertain significance Single submitter
- ADAM19 p.Pro315Arg Uncertain significance Single submitter
- ADAM19 p.Pro315Ser Uncertain significance Single submitter
- ADAM19 p.Pro780Leu Uncertain significance Single submitter
- ADAM19 p.Pro803Leu Uncertain significance Single submitter
- ADAM19 p.Pro821Ser Uncertain significance Single submitter
- ADAM19 p.Ser208Phe Uncertain significance Single submitter
- ADAM19 p.Ser736Pro Uncertain significance Single submitter
- ADAM19 p.Thr140Lys Uncertain significance Single submitter
- ADAM19 p.Thr183Ile Uncertain significance Single submitter
- ADAM19 p.Thr779Ile Uncertain significance Single submitter
- ADAM19 p.Tyr797Phe Uncertain significance Single submitter
- ADAM19 p.Val716Ile Uncertain significance Single submitter
- ADAM19 p.Val848Ile Uncertain significance Single submitter
Predictors split 53
The independent predictors disagree with each other — read with care.
- ADAM19 p.Ala241Val Uncertain significance Single submitter
- ADAM19 p.Ala24Glu Uncertain significance Single submitter
- ADAM19 p.Ala511Gly Uncertain significance Single submitter
- ADAM19 p.Ala8Gly Uncertain significance Single submitter
- ADAM19 p.Arg417Trp Uncertain significance Single submitter
- ADAM19 p.Arg583Gln Uncertain significance Single submitter
- ADAM19 p.Arg583Trp Uncertain significance Single submitter
- ADAM19 p.Arg606Trp Uncertain significance Single submitter
- ADAM19 p.Arg68Gly Uncertain significance Single submitter
- ADAM19 p.Arg74Gln Uncertain significance Single submitter
- ADAM19 p.Arg784Trp Uncertain significance Single submitter
- ADAM19 p.Arg792Gln Uncertain significance Single submitter
- ADAM19 p.Arg792Trp Uncertain significance Single submitter
- ADAM19 p.Arg838Gln Uncertain significance Single submitter
- ADAM19 p.Arg870Cys Uncertain significance Single submitter
- ADAM19 p.Arg883Trp Uncertain significance Single submitter
- ADAM19 p.Arg893Trp Uncertain significance Single submitter
- ADAM19 p.Asn497Asp Uncertain significance Single submitter
- ADAM19 p.Asn588Ser Uncertain significance Single submitter
- ADAM19 p.Asn659Ser Uncertain significance Single submitter
- ADAM19 p.Gln464His Uncertain significance Single submitter
- ADAM19 p.Glu150Lys Uncertain significance Single submitter
- ADAM19 p.Gly308Ser Uncertain significance Single submitter
- ADAM19 p.Gly509Ser Uncertain significance Single submitter
- ADAM19 p.His178Tyr Uncertain significance Single submitter
- ADAM19 p.His43Arg Uncertain significance Single submitter
- ADAM19 p.Leu63Phe Likely benign Single submitter
- ADAM19 p.Leu717Phe Uncertain significance Single submitter
- ADAM19 p.Leu873Phe Uncertain significance Single submitter
- ADAM19 p.Leu882Met Uncertain significance Single submitter
- ADAM19 p.Lys234Gln Uncertain significance Single submitter
- ADAM19 p.Lys564Met Uncertain significance Single submitter
- ADAM19 p.Lys571Arg Uncertain significance Single submitter
- ADAM19 p.Pro452Leu Uncertain significance Single submitter
- ADAM19 p.Pro484Leu Uncertain significance Single submitter
- ADAM19 p.Pro505Leu Uncertain significance Single submitter
- ADAM19 p.Pro535Ser Uncertain significance Single submitter
- ADAM19 p.Pro684Ser Uncertain significance Single submitter
- ADAM19 p.Pro694Ser Benign Single submitter
- ADAM19 p.Pro839Ser Uncertain significance Single submitter
- ADAM19 p.Pro841Arg Uncertain significance Single submitter
- ADAM19 p.Pro863Leu Uncertain significance Single submitter
- ADAM19 p.Ser305Phe Uncertain significance Single submitter
- ADAM19 p.Ser753Phe Uncertain significance Single submitter
- ADAM19 p.Thr118Met Uncertain significance Single submitter
- ADAM19 p.Thr131Ala Uncertain significance Single submitter
- ADAM19 p.Thr828Met Uncertain significance Single submitter
- ADAM19 p.Tyr243Cys Uncertain significance Single submitter
- ADAM19 p.Val127Ile Uncertain significance Single submitter
- ADAM19 p.Val339Met Uncertain significance Single submitter
- ADAM19 p.Val383Ala Uncertain significance Single submitter
- ADAM19 p.Val700Met Uncertain significance Single submitter
- ADAM19 p.Val713Met Uncertain significance Single submitter
All ADAM19 variants
Benign 8
- c.1986+3G>A Single submitter
- c.906-7C>A Single submitter
- p.Ala805Thr Single submitter
- p.Gln103Glu Single submitter
- p.Pro694Ser Single submitter ⚠
- p.Pro834Ala Single submitter
- p.Pro842= Single submitter
- p.Pro855Ser No assertion criteria Abnormality of neuronal migration
Likely benign 11
- p.Ala715Val Single submitter
- p.Ala814Thr Single submitter
- p.Arg893Gln Single submitter
- p.His458= Single submitter
- p.His686= Single submitter
- p.Ile914Thr Single submitter
- p.Leu63Phe Single submitter ⚠
- p.Pro171Leu Single submitter
- p.Thr122Ala Single submitter
- p.Thr140Met Single submitter
- p.Thr828Lys Single submitter
Uncertain significance 118
- c.1130+67G>T Single submitter lung adenocarcinoma
- c.180+659A>C Single submitter lung adenocarcinoma
- c.251+324T>G Single submitter lung adenocarcinoma
- c.252-190C>A Single submitter squamous cell carcinoma
- c.252-193T>G Single submitter squamous cell carcinoma
- p.Ala241Val Single submitter ⚠
- p.Ala24Glu Single submitter ⚠
- p.Ala336Val Single submitter ⚠
- p.Ala365Gly Single submitter ⚠
- p.Ala365Val Single submitter ⚠
- p.Ala511Gly Single submitter ⚠
- p.Ala815Gly Single submitter ⚠
- p.Ala843Ser Single submitter ⚠
- p.Ala843Thr Single submitter ⚠
- p.Ala861Val Single submitter ⚠
- p.Ala8Gly Single submitter ⚠
- p.Arg107Gln Single submitter ⚠
- p.Arg107Trp Single submitter ⚠
- p.Arg23Gln Single submitter ⚠
- p.Arg417Gln Single submitter ⚠
- p.Arg417Trp Single submitter ⚠
- p.Arg475Cys Single submitter ⚠
- p.Arg583Gln Single submitter ⚠
- p.Arg583Trp Single submitter ⚠
- p.Arg606Trp Single submitter ⚠
- p.Arg68Gly Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Arg751Thr Single submitter ⚠
- p.Arg774Gln Single submitter ⚠
- p.Arg784Gln Single submitter ⚠
- p.Arg784Trp Single submitter ⚠
- p.Arg792Gln Single submitter ⚠
- p.Arg792Trp Single submitter ⚠
- p.Arg813Gly Single submitter ⚠
- p.Arg838Gln Single submitter ⚠
- p.Arg854Gly Single submitter ⚠
- p.Arg856Gln Single submitter ⚠
- p.Arg870Cys Single submitter ⚠
- p.Arg883Trp Single submitter ⚠
- p.Arg893Trp Single submitter ⚠
- p.Asn144Ser Single submitter ⚠
- p.Asn497Asp Single submitter ⚠
- p.Asn588Ser Single submitter ⚠
- p.Asn659Ser Single submitter ⚠
- p.Asn817Ile Single submitter ⚠
- p.Asp393Gly Single submitter ⚠
- p.Cys174Tyr Single submitter ⚠
- p.Cys361Arg Single submitter ⚠
- p.Cys540Trp Single submitter ⚠
- p.Cys672Ser Single submitter ⚠
- p.Cys748Phe Single submitter ⚠
- p.Gln464His Single submitter ⚠
- p.Gln668His Single submitter ⚠
- p.Gln754His Single submitter ⚠
- p.Gln908Arg Single submitter
- p.Glu150Lys Single submitter ⚠
- p.Glu177Lys Single submitter ⚠
- p.Gly117Ser Single submitter ⚠
- p.Gly308Ser Single submitter ⚠
- p.Gly509Ser Single submitter ⚠
- p.Gly653Ala Single submitter ⚠
- p.Gly759Ala Single submitter ⚠
- p.Gly822Ala Single submitter ⚠
- p.His178Tyr Single submitter ⚠
- p.His265Arg Single submitter ⚠
- p.His43Arg Single submitter ⚠
- p.His760Leu Single submitter ⚠
- p.Leu160Phe Single submitter ⚠
- p.Leu251Trp Single submitter ⚠
- p.Leu539Phe Single submitter ⚠
- p.Leu717Phe Single submitter ⚠
- p.Leu873Phe Single submitter ⚠
- p.Leu882Met Single submitter ⚠
- p.Lys234Arg Single submitter ⚠
- p.Lys234Gln Single submitter ⚠
- p.Lys246Glu Single submitter ⚠
- p.Lys40Arg Single submitter ⚠
- p.Lys564Met Single submitter ⚠
- p.Lys571Arg Single submitter ⚠
- p.Lys901Glu Single submitter ⚠
- p.Met304Val Single submitter ⚠
- p.Met558Ile Single submitter ⚠
- p.Met567Arg Single submitter ⚠
- p.Met913Thr Single submitter
- p.Phe176Leu Single submitter ⚠
- p.Pro315Ala Single submitter ⚠
- p.Pro315Arg Single submitter ⚠
- p.Pro315Ser Single submitter ⚠
- p.Pro452Leu Single submitter ⚠
- p.Pro484Leu Single submitter ⚠
- p.Pro505Leu Single submitter ⚠
- p.Pro535Ser Single submitter ⚠
- p.Pro684Ser Single submitter ⚠
- p.Pro780Leu Single submitter ⚠
- p.Pro803Leu Single submitter ⚠
- p.Pro821Ser Single submitter ⚠
- p.Pro839Ser Single submitter ⚠
- p.Pro841Arg Single submitter ⚠
- p.Pro863Leu Single submitter ⚠
- p.Ser208Phe Single submitter ⚠
- p.Ser305Phe Single submitter ⚠
- p.Ser736Pro Single submitter ⚠
- p.Ser753Phe Single submitter ⚠
- p.Thr118Met Single submitter ⚠
- p.Thr131Ala Single submitter ⚠
- p.Thr140Lys Single submitter ⚠
- p.Thr183Ile Single submitter ⚠
- p.Thr779Ile Single submitter ⚠
- p.Thr828Met Single submitter ⚠
- p.Tyr243Cys Single submitter ⚠
- p.Tyr797Phe Single submitter ⚠
- p.Val127Ile Single submitter ⚠
- p.Val339Met Single submitter ⚠
- p.Val383Ala Single submitter ⚠
- p.Val700Met Single submitter ⚠
- p.Val713Met Single submitter ⚠
- p.Val716Ile Single submitter ⚠
- p.Val848Ile Single submitter ⚠