ADAM20 — 126 ClinVar variants
All ClinVar germline ADAM20 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →
11 Likely benign · 115 Uncertain significance
Full ADAM20 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 109
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM20 p.Ala2Val Uncertain significance Single submitter
- ADAM20 p.Ala311Asp Uncertain significance Single submitter
- ADAM20 p.Arg32Met Uncertain significance Single submitter
- ADAM20 p.Arg427Trp Uncertain significance Single submitter
- ADAM20 p.Arg66Gln Uncertain significance Single submitter
- ADAM20 p.Arg692His Uncertain significance Single submitter
- ADAM20 p.Asn191Asp Uncertain significance Single submitter
- ADAM20 p.Asp251Gly Uncertain significance Single submitter
- ADAM20 p.Asp493Asn Uncertain significance Single submitter
- ADAM20 p.Asp522Gly Uncertain significance Single submitter
- ADAM20 p.Cys357Gly Uncertain significance Single submitter
- ADAM20 p.Cys421Arg Uncertain significance Single submitter
- ADAM20 p.Cys421Tyr Uncertain significance Single submitter
- ADAM20 p.Cys423Tyr Uncertain significance Single submitter
- ADAM20 p.Cys435Trp Uncertain significance Single submitter
- ADAM20 p.Cys447Arg Uncertain significance Single submitter
- ADAM20 p.Cys452Arg Uncertain significance Single submitter
- ADAM20 p.Cys497Tyr Uncertain significance Single submitter
- ADAM20 p.Cys508Tyr Uncertain significance Single submitter
- ADAM20 p.Cys530Tyr Uncertain significance Single submitter
- ADAM20 p.Cys614Trp Uncertain significance Single submitter
- ADAM20 p.Cys663Trp Uncertain significance Single submitter
- ADAM20 p.Gln355His Uncertain significance Single submitter
- ADAM20 p.Gln537Arg Uncertain significance Single submitter
- ADAM20 p.Glu120Lys Uncertain significance Single submitter
- ADAM20 p.Glu343Lys Uncertain significance Single submitter
- ADAM20 p.Glu360Lys Uncertain significance Single submitter
- ADAM20 p.Glu416Asp Uncertain significance Single submitter
- ADAM20 p.Glu683Val Uncertain significance Single submitter
- ADAM20 p.Glu94Gly Uncertain significance Single submitter
- ADAM20 p.Gly309Cys Uncertain significance Single submitter
- ADAM20 p.Gly309Ser Uncertain significance Single submitter
- ADAM20 p.Gly402Glu Uncertain significance Single submitter
- ADAM20 p.Gly606Val Uncertain significance Single submitter
- ADAM20 p.Gly667Cys Uncertain significance Single submitter
- ADAM20 p.His232Tyr Uncertain significance Single submitter
- ADAM20 p.His246Arg Uncertain significance Single submitter
- ADAM20 p.His28Tyr Uncertain significance Single submitter
- ADAM20 p.Ile148Val Uncertain significance Single submitter
- ADAM20 p.Ile240Met Uncertain significance Single submitter
- ADAM20 p.Ile602Val Uncertain significance Single submitter
- ADAM20 p.Leu287Pro Uncertain significance Single submitter
- ADAM20 p.Leu474Pro Uncertain significance Single submitter
- ADAM20 p.Leu685Ser Uncertain significance Single submitter
- ADAM20 p.Lys283Arg Uncertain significance Single submitter
- ADAM20 p.Met171Val Uncertain significance Single submitter
- ADAM20 p.Met560Thr Uncertain significance Single submitter
- ADAM20 p.Met688Leu Uncertain significance Single submitter
- ADAM20 p.Phe208Leu Uncertain significance Single submitter
- ADAM20 p.Phe376Cys Uncertain significance Single submitter
- ADAM20 p.Phe541Val Uncertain significance Single submitter
- ADAM20 p.Pro170His Uncertain significance Single submitter
- ADAM20 p.Ser163Gly Uncertain significance Single submitter
- ADAM20 p.Thr166Ile Uncertain significance Single submitter
- ADAM20 p.Thr193Ala Uncertain significance Single submitter
- ADAM20 p.Thr481Ser Uncertain significance Single submitter
- ADAM20 p.Thr507Met Uncertain significance Single submitter
- ADAM20 p.Tyr384His Uncertain significance Single submitter
- ADAM20 p.Val237Ile Uncertain significance Single submitter
- ADAM20 p.Val237Phe Uncertain significance Single submitter
- ADAM20 p.Val491Leu Uncertain significance Single submitter
- ADAM20 p.Val74Ile Uncertain significance Single submitter
Predictors split 47
The independent predictors disagree with each other — read with care.
- ADAM20 p.Ala124Pro Uncertain significance Single submitter
- ADAM20 p.Ala526Ser Uncertain significance Single submitter
- ADAM20 p.Arg207Trp Uncertain significance Single submitter
- ADAM20 p.Arg66Trp Uncertain significance Single submitter
- ADAM20 p.Asn217Asp Uncertain significance Single submitter
- ADAM20 p.Asn239Ser Uncertain significance Single submitter
- ADAM20 p.Asn79Tyr Uncertain significance Single submitter
- ADAM20 p.Asp488Ala Uncertain significance Single submitter
- ADAM20 p.Cys173Gly Uncertain significance Single submitter
- ADAM20 p.Gln468Arg Uncertain significance Single submitter
- ADAM20 p.Gln514His Uncertain significance Single submitter
- ADAM20 p.Glu116Gln Uncertain significance Single submitter
- ADAM20 p.Glu185Gly Uncertain significance Single submitter
- ADAM20 p.Glu420Asp Uncertain significance Single submitter
- ADAM20 p.Gly27Asp Uncertain significance Single submitter
- ADAM20 p.Gly444Arg Uncertain significance Single submitter
- ADAM20 p.Gly462Arg Uncertain significance Single submitter
- ADAM20 p.Gly494Arg Uncertain significance Single submitter
- ADAM20 p.Gly52Asp Uncertain significance Single submitter
- ADAM20 p.His651Arg Uncertain significance Single submitter
- ADAM20 p.Ile559Thr Uncertain significance Single submitter
- ADAM20 p.Leu291Arg Uncertain significance Single submitter
- ADAM20 p.Leu700Phe Uncertain significance Single submitter
- ADAM20 p.Lys666Glu Uncertain significance Single submitter
- ADAM20 p.Met350Val Uncertain significance Single submitter
- ADAM20 p.Pro40Ser Likely benign Single submitter
- ADAM20 p.Ser29Phe Uncertain significance Single submitter
- ADAM20 p.Ser377Arg Uncertain significance Single submitter
- ADAM20 p.Ser579Phe Uncertain significance Single submitter
- ADAM20 p.Ser64Asn Uncertain significance Single submitter
- ADAM20 p.Thr228Ile Uncertain significance Single submitter
- ADAM20 p.Thr261Ala Uncertain significance Single submitter
- ADAM20 p.Thr268Ala Uncertain significance Single submitter
- ADAM20 p.Thr639Ala Uncertain significance Single submitter
- ADAM20 p.Thr93Ile Uncertain significance Single submitter
- ADAM20 p.Trp385Arg Uncertain significance Single submitter
- ADAM20 p.Tyr110Cys Uncertain significance Single submitter
- ADAM20 p.Tyr114His Uncertain significance Single submitter
- ADAM20 p.Tyr159Cys Uncertain significance Single submitter
- ADAM20 p.Tyr245Cys Uncertain significance Single submitter
- ADAM20 p.Tyr36Cys Uncertain significance Single submitter
- ADAM20 p.Tyr490Cys Uncertain significance Single submitter
- ADAM20 p.Tyr551Cys Uncertain significance Single submitter
- ADAM20 p.Val158Leu Uncertain significance Single submitter
- ADAM20 p.Val209Ala Uncertain significance Single submitter
- ADAM20 p.Val215Met Uncertain significance Single submitter
- ADAM20 p.Val415Ile Uncertain significance Single submitter
All ADAM20 variants
Likely benign 11
- p.Ala85Thr Single submitter
- p.Arg427Gln Single submitter
- p.Arg622His Single submitter
- p.Arg71= Single submitter
- p.Ile451Met Single submitter
- p.Met135Val Single submitter
- p.Pro40Ser Single submitter ⚠
- p.Thr38Ser Single submitter
- p.Thr507Arg Single submitter
- p.Val335Ile Single submitter
- p.Val372Leu Single submitter
Uncertain significance 115
- c.-117A>T Single submitter
- c.-125A>G Single submitter
- c.-63G>A Single submitter
- c.-71C>G Single submitter
- c.-77G>A Single submitter
- c.-90A>G Single submitter
- p.Ala124Pro Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala311Asp Single submitter ⚠
- p.Ala526Ser Single submitter ⚠
- p.Arg207Trp Single submitter ⚠
- p.Arg32Met Single submitter ⚠
- p.Arg427Trp Single submitter ⚠
- p.Arg66Gln Single submitter ⚠
- p.Arg66Trp Single submitter ⚠
- p.Arg692His Single submitter ⚠
- p.Asn191Asp Single submitter ⚠
- p.Asn217Asp Single submitter ⚠
- p.Asn239Ser Single submitter ⚠
- p.Asn79Tyr Single submitter ⚠
- p.Asp251Gly Single submitter ⚠
- p.Asp488Ala Single submitter ⚠
- p.Asp493Asn Single submitter ⚠
- p.Asp522Gly Single submitter ⚠
- p.Cys173Gly Single submitter ⚠
- p.Cys357Gly Single submitter ⚠
- p.Cys421Arg Single submitter ⚠
- p.Cys421Tyr Single submitter ⚠
- p.Cys423Tyr Single submitter ⚠
- p.Cys435Trp Single submitter ⚠
- p.Cys447Arg Single submitter ⚠
- p.Cys452Arg Single submitter ⚠
- p.Cys497Tyr Single submitter ⚠
- p.Cys508Tyr Single submitter ⚠
- p.Cys530Tyr Single submitter ⚠
- p.Cys614Trp Single submitter ⚠
- p.Cys663Trp Single submitter ⚠
- p.Gln355His Single submitter ⚠
- p.Gln468Arg Single submitter ⚠
- p.Gln514His Single submitter ⚠
- p.Gln537Arg Single submitter ⚠
- p.Glu116Gln Single submitter ⚠
- p.Glu120Lys Single submitter ⚠
- p.Glu185Gly Single submitter ⚠
- p.Glu343Lys Single submitter ⚠
- p.Glu360Lys Single submitter ⚠
- p.Glu416Asp Single submitter ⚠
- p.Glu420Asp Single submitter ⚠
- p.Glu683Val Single submitter ⚠
- p.Glu94Gly Single submitter ⚠
- p.Gly27Asp Single submitter ⚠
- p.Gly309Cys Single submitter ⚠
- p.Gly309Ser Single submitter ⚠
- p.Gly402Glu Single submitter ⚠
- p.Gly444Arg Single submitter ⚠
- p.Gly462Arg Single submitter ⚠
- p.Gly494Arg Single submitter ⚠
- p.Gly52Asp Single submitter ⚠
- p.Gly606Val Single submitter ⚠
- p.Gly667Cys Single submitter ⚠
- p.His232Tyr Single submitter ⚠
- p.His246Arg Single submitter ⚠
- p.His28Tyr Single submitter ⚠
- p.His651Arg Single submitter ⚠
- p.Ile148Val Single submitter ⚠
- p.Ile240Met Single submitter ⚠
- p.Ile559Thr Single submitter ⚠
- p.Ile602Val Single submitter ⚠
- p.Leu287Pro Single submitter ⚠
- p.Leu291Arg Single submitter ⚠
- p.Leu474Pro Single submitter ⚠
- p.Leu685Ser Single submitter ⚠
- p.Leu700Phe Single submitter ⚠
- p.Lys283Arg Single submitter ⚠
- p.Lys666Glu Single submitter ⚠
- p.Met171Val Single submitter ⚠
- p.Met1Val Single submitter
- p.Met350Val Single submitter ⚠
- p.Met560Thr Single submitter ⚠
- p.Met688Leu Single submitter ⚠
- p.Phe208Leu Single submitter ⚠
- p.Phe376Cys Single submitter ⚠
- p.Phe541Val Single submitter ⚠
- p.Pro170His Single submitter ⚠
- p.Ser163Gly Single submitter ⚠
- p.Ser29Phe Single submitter ⚠
- p.Ser377Arg Single submitter ⚠
- p.Ser579Phe Single submitter ⚠
- p.Ser64Asn Single submitter ⚠
- p.Thr166Ile Single submitter ⚠
- p.Thr193Ala Single submitter ⚠
- p.Thr228Ile Single submitter ⚠
- p.Thr261Ala Single submitter ⚠
- p.Thr268Ala Single submitter ⚠
- p.Thr481Ser Single submitter ⚠
- p.Thr507Met Single submitter ⚠
- p.Thr639Ala Single submitter ⚠
- p.Thr93Ile Single submitter ⚠
- p.Trp385Arg Single submitter ⚠
- p.Tyr110Cys Single submitter ⚠
- p.Tyr114His Single submitter ⚠
- p.Tyr159Cys Single submitter ⚠
- p.Tyr245Cys Single submitter ⚠
- p.Tyr36Cys Single submitter ⚠
- p.Tyr384His Single submitter ⚠
- p.Tyr490Cys Single submitter ⚠
- p.Tyr551Cys Single submitter ⚠
- p.Val158Leu Single submitter ⚠
- p.Val209Ala Single submitter ⚠
- p.Val215Met Single submitter ⚠
- p.Val237Ile Single submitter ⚠
- p.Val237Phe Single submitter ⚠
- p.Val415Ile Single submitter ⚠
- p.Val491Leu Single submitter ⚠
- p.Val74Ile Single submitter ⚠