ADAM23 — 102 ClinVar variants

All ClinVar germline ADAM23 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →

2 Benign · 1 Benign/Likely benign · 12 Likely benign · 87 Uncertain significance

Full ADAM23 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 87

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 54

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 33

The independent predictors disagree with each other — read with care.

All ADAM23 variants

Benign 2

p.Ser693= Multiple submitters
c.1852+9C>T Single submitter

Benign/Likely benign 1

p.Pro780Ala Multiple submitters

Likely benign 12

p.Ile118Met Multiple submitters ⚠
p.Phe158= Multiple submitters
p.Ser125Ala Multiple submitters
c.868-4G>A Single submitter
p.Asp588= Single submitter
p.Gly465= Single submitter
p.Ile294Val Single submitter
p.Ile336= Single submitter
p.Leu499= Single submitter
p.Lys209Arg Single submitter
p.Met107Val Single submitter
p.Val205Ile Single submitter

Uncertain significance 87

p.Ala145Gly Single submitter ⚠
p.Ala287Thr Single submitter ⚠
p.Ala37Val Single submitter ⚠
p.Ala39Gly Single submitter ⚠
p.Ala764Val Single submitter ⚠
p.Arg27Cys Single submitter ⚠
p.Arg284Thr Single submitter ⚠
p.Arg292Cys Single submitter ⚠
p.Arg292His Single submitter ⚠
p.Arg344Ser Single submitter ⚠
p.Arg344Thr Single submitter ⚠
p.Arg376Gln Single submitter ⚠
p.Arg376Trp Single submitter ⚠
p.Arg378His Single submitter ⚠
p.Arg40Gly Single submitter ⚠
p.Arg410His Single submitter ⚠
p.Arg45Cys Single submitter ⚠
p.Arg598Cys Single submitter ⚠
p.Arg61Trp Single submitter ⚠
p.Arg646Gln Single submitter ⚠
p.Arg667Gln Single submitter ⚠
p.Arg670His Single submitter ⚠
p.Arg723Gln Single submitter ⚠
p.Arg771Trp Single submitter ⚠
p.Asn323Ser Single submitter ⚠
p.Asn583His Single submitter ⚠
p.Asn595Lys Single submitter ⚠
p.Asp239Gly Single submitter ⚠
p.Asp588Gly Single submitter ⚠
p.Asp608Glu Single submitter ⚠
p.Asp654Asn Single submitter ⚠
p.Asp700Gly Single submitter ⚠
p.Asp739Asn Single submitter ⚠
p.Asp772Ala Single submitter ⚠
p.Asp772Tyr Single submitter ⚠
p.Cys23Arg Single submitter ⚠
p.Cys757fs Single submitter
p.Gln256Arg Single submitter ⚠
p.Gln95His Single submitter ⚠
p.Glu235Ala Single submitter ⚠
p.Glu80Gly Single submitter ⚠
p.Gly192Ser Single submitter ⚠
p.Gly557Glu Single submitter ⚠
p.Gly5Arg Single submitter ⚠
p.Gly602Ser Single submitter ⚠
p.Gly644Glu Single submitter ⚠
p.Gly815Ala Single submitter ⚠
p.His199Arg Single submitter ⚠
p.His319Tyr Single submitter ⚠
p.His382Leu Single submitter ⚠
p.His539Arg Single submitter ⚠
p.His748Arg Single submitter ⚠
p.His74Leu Single submitter ⚠
p.Ile111Thr Single submitter ⚠
p.Ile118Thr Single submitter ⚠
p.Ile121Leu Single submitter ⚠
p.Ile180Ser Single submitter ⚠
p.Ile231Met Single submitter ⚠
p.Ile248Thr Single submitter ⚠
p.Ile361Val Single submitter ⚠
p.Leu132Ile Single submitter ⚠
p.Leu83Ser Single submitter ⚠
p.Lys380Glu Single submitter ⚠
p.Lys637Asn Single submitter ⚠
p.Lys743Glu Single submitter ⚠
p.Lys820Arg Single submitter ⚠
p.Met221Leu Single submitter ⚠
p.Phe625Ser Single submitter ⚠
p.Pro34Ser Single submitter ⚠
p.Pro502Leu Single submitter ⚠
p.Pro780Arg Single submitter ⚠
p.Pro780His Single submitter ⚠
p.Ser115Ala Single submitter ⚠
p.Ser125Leu Single submitter ⚠
p.Ser276Cys Single submitter ⚠
p.Ser71Asn Single submitter ⚠
p.Ser735Arg Single submitter ⚠
p.Thr41Met Single submitter ⚠
p.Thr41Pro Single submitter ⚠
p.Thr503Ser Single submitter ⚠
p.Thr666Ile Single submitter ⚠
p.Thr703Met Single submitter ⚠
p.Trp280Ser Single submitter ⚠
p.Tyr120Asn Single submitter ⚠
p.Tyr558His Single submitter ⚠
p.Val205Ala Single submitter ⚠
p.Val228Met Single submitter ⚠