ADAM28 — 123 ClinVar variants
All ClinVar germline ADAM28 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
1 Benign · 12 Likely benign · 110 Uncertain significance
Full ADAM28 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM28 p.Ala556Ser Uncertain significance Single submitter
- ADAM28 p.Ala676Thr Uncertain significance Single submitter
- ADAM28 p.Ala775Pro Uncertain significance Single submitter
- ADAM28 p.Arg578Gln Uncertain significance Single submitter
- ADAM28 p.Asn113Ser Uncertain significance Single submitter
- ADAM28 p.Asn183Lys Uncertain significance Single submitter
- ADAM28 p.Asn431Asp Uncertain significance Single submitter
- ADAM28 p.Asn742Ser Uncertain significance Single submitter
- ADAM28 p.Asp103Asn Uncertain significance Single submitter
- ADAM28 p.Asp104Gly Uncertain significance Single submitter
- ADAM28 p.Asp172Asn Uncertain significance Single submitter
- ADAM28 p.Asp528Gly Uncertain significance Single submitter
- ADAM28 p.Cys105Ser Uncertain significance Single submitter
- ADAM28 p.Cys124Arg Uncertain significance Single submitter
- ADAM28 p.Cys429Arg Uncertain significance Single submitter
- ADAM28 p.Cys439Tyr Uncertain significance Single submitter
- ADAM28 p.Cys453Phe Uncertain significance Single submitter
- ADAM28 p.Cys456Phe Uncertain significance Single submitter
- ADAM28 p.Cys509Phe Uncertain significance Single submitter
- ADAM28 p.Cys612Phe Uncertain significance Single submitter
- ADAM28 p.Cys645Arg Uncertain significance Single submitter
- ADAM28 p.Cys647Phe Uncertain significance Single submitter
- ADAM28 p.Cys647Ser Uncertain significance Single submitter
- ADAM28 p.Gln567His Uncertain significance Single submitter
- ADAM28 p.Gln695Arg Uncertain significance Single submitter
- ADAM28 p.Glu233Asp Uncertain significance Single submitter
- ADAM28 p.Glu300Asp Uncertain significance Single submitter
- ADAM28 p.Glu46Asp Uncertain significance Single submitter
- ADAM28 p.Glu743Lys Uncertain significance Single submitter
- ADAM28 p.Gly126Asp Uncertain significance Single submitter
- ADAM28 p.Gly173Ser Uncertain significance Single submitter
- ADAM28 p.Gly342Arg Uncertain significance Single submitter
- ADAM28 p.Gly346Glu Uncertain significance Single submitter
- ADAM28 p.Gly4Val Uncertain significance Single submitter
- ADAM28 p.Gly542Trp Uncertain significance Single submitter
- ADAM28 p.Gly741Asp Uncertain significance Single submitter
- ADAM28 p.His641Gln Uncertain significance Single submitter
- ADAM28 p.Ile19Val Uncertain significance Single submitter
- ADAM28 p.Ile206Val Uncertain significance Single submitter
- ADAM28 p.Ile292Met Uncertain significance Single submitter
- ADAM28 p.Ile597Met Uncertain significance Single submitter
- ADAM28 p.Leu127Pro Uncertain significance Single submitter
- ADAM28 p.Leu22Ile Uncertain significance Single submitter
- ADAM28 p.Leu474Pro Uncertain significance Single submitter
- ADAM28 p.Leu551Val Uncertain significance Single submitter
- ADAM28 p.Lys115Asn Uncertain significance Single submitter
- ADAM28 p.Lys278Glu Uncertain significance Single submitter
- ADAM28 p.Lys501Arg Uncertain significance Single submitter
- ADAM28 p.Lys625Gln Uncertain significance Single submitter
- ADAM28 p.Met234Ile Uncertain significance Single submitter
- ADAM28 p.Met254Val Uncertain significance Single submitter
- ADAM28 p.Met506Ile Uncertain significance Single submitter
- ADAM28 p.Pro590Thr Uncertain significance Single submitter
- ADAM28 p.Pro701Ala Uncertain significance Single submitter
- ADAM28 p.Pro716Thr Uncertain significance Single submitter
- ADAM28 p.Ser13Phe Uncertain significance Single submitter
- ADAM28 p.Ser270Asn Uncertain significance Single submitter
- ADAM28 p.Ser376Gly Uncertain significance Single submitter
- ADAM28 p.Ser379Ile Uncertain significance Single submitter
- ADAM28 p.Ser570Leu Uncertain significance Single submitter
- ADAM28 p.Thr299Arg Uncertain significance Single submitter
- ADAM28 p.Thr604Ala Uncertain significance Single submitter
- ADAM28 p.Thr758Asn Uncertain significance Single submitter
- ADAM28 p.Trp651Cys Uncertain significance Single submitter
- ADAM28 p.Tyr532Cys Uncertain significance Single submitter
- ADAM28 p.Val661Met Uncertain significance Single submitter
Predictors split 47
The independent predictors disagree with each other — read with care.
- ADAM28 p.Val322Ile Likely benign Multiple submitters
- ADAM28 p.Ala119Thr Uncertain significance Single submitter
- ADAM28 p.Ala250Val Uncertain significance Single submitter
- ADAM28 p.Ala293Val Uncertain significance Single submitter
- ADAM28 p.Arg289Cys Uncertain significance Single submitter
- ADAM28 p.Arg42Thr Uncertain significance Single submitter
- ADAM28 p.Arg545Leu Uncertain significance Single submitter
- ADAM28 p.Arg578Trp Uncertain significance Single submitter
- ADAM28 p.Asn183Ile Uncertain significance Single submitter
- ADAM28 p.Asn223Tyr Uncertain significance Single submitter
- ADAM28 p.Asn246Ile Uncertain significance Single submitter
- ADAM28 p.Asn344Ser Uncertain significance Single submitter
- ADAM28 p.Asp103Ala Uncertain significance Single submitter
- ADAM28 p.Asp528Tyr Uncertain significance Single submitter
- ADAM28 p.Asp655Gly Uncertain significance Single submitter
- ADAM28 p.Gln108Arg Uncertain significance Single submitter
- ADAM28 p.Glu255Asp Uncertain significance Single submitter
- ADAM28 p.Glu693Gly Likely benign Single submitter
- ADAM28 p.Gly170Glu Uncertain significance Single submitter
- ADAM28 p.Gly523Ala Uncertain significance Single submitter
- ADAM28 p.Gly650Glu Uncertain significance Single submitter
- ADAM28 p.Ile206Thr Uncertain significance Single submitter
- ADAM28 p.Ile432Met Uncertain significance Single submitter
- ADAM28 p.Ile579Thr Uncertain significance Single submitter
- ADAM28 p.Leu180Trp Uncertain significance Single submitter
- ADAM28 p.Leu70Phe Uncertain significance Single submitter
- ADAM28 p.Lys157Asn Uncertain significance Single submitter
- ADAM28 p.Met254Thr Uncertain significance Single submitter
- ADAM28 p.Met337Leu Uncertain significance Single submitter
- ADAM28 p.Met727Ile Uncertain significance Single submitter
- ADAM28 p.Phe139Leu Uncertain significance Single submitter
- ADAM28 p.Phe445Cys Uncertain significance Single submitter
- ADAM28 p.Pro522Leu Uncertain significance Single submitter
- ADAM28 p.Ser117Ala Uncertain significance Single submitter
- ADAM28 p.Ser17Asn Likely benign Single submitter
- ADAM28 p.Thr304Lys Uncertain significance Single submitter
- ADAM28 p.Thr373Ile Uncertain significance Single submitter
- ADAM28 p.Thr425Pro Uncertain significance Single submitter
- ADAM28 p.Thr430Ala Uncertain significance Single submitter
- ADAM28 p.Thr511Ile Uncertain significance Single submitter
- ADAM28 p.Thr84Met Uncertain significance Single submitter
- ADAM28 p.Thr96Ala Uncertain significance Single submitter
- ADAM28 p.Trp176Cys Uncertain significance Single submitter
- ADAM28 p.Tyr130Cys Uncertain significance Single submitter
- ADAM28 p.Tyr370Cys Uncertain significance Single submitter
- ADAM28 p.Val306Leu Uncertain significance Single submitter
- ADAM28 p.Val320Ile Uncertain significance Single submitter
All ADAM28 variants
Benign 1
- p.His147Asn Single submitter
Likely benign 12
- p.Asn484= Multiple submitters
- p.Val322Ile Multiple submitters ⚠
- c.2244+811A>G Single submitter
- p.Ala302Ser Single submitter
- p.Asp655Asn Single submitter
- p.Glu693Gly Single submitter ⚠
- p.Met675Val Single submitter
- p.Pro757Ser Single submitter
- p.Ser17Asn Single submitter ⚠
- p.Ser570= Single submitter
- p.Thr444Ser Single submitter
- p.Tyr370= Single submitter
Uncertain significance 110
- p.Ala119Thr Single submitter ⚠
- p.Ala250Val Single submitter ⚠
- p.Ala293Val Single submitter ⚠
- p.Ala556Ser Single submitter ⚠
- p.Ala676Thr Single submitter ⚠
- p.Ala775Pro Single submitter ⚠
- p.Arg289Cys Single submitter ⚠
- p.Arg42Thr Single submitter ⚠
- p.Arg545Leu Single submitter ⚠
- p.Arg578Gln Single submitter ⚠
- p.Arg578Trp Single submitter ⚠
- p.Asn113Ser Single submitter ⚠
- p.Asn183Ile Single submitter ⚠
- p.Asn183Lys Single submitter ⚠
- p.Asn223Tyr Single submitter ⚠
- p.Asn246Ile Single submitter ⚠
- p.Asn344Ser Single submitter ⚠
- p.Asn431Asp Single submitter ⚠
- p.Asn742Ser Single submitter ⚠
- p.Asp103Ala Single submitter ⚠
- p.Asp103Asn Single submitter ⚠
- p.Asp104Gly Single submitter ⚠
- p.Asp172Asn Single submitter ⚠
- p.Asp528Gly Single submitter ⚠
- p.Asp528Tyr Single submitter ⚠
- p.Asp655Gly Single submitter ⚠
- p.Cys105Ser Single submitter ⚠
- p.Cys124Arg Single submitter ⚠
- p.Cys429Arg Single submitter ⚠
- p.Cys439Tyr Single submitter ⚠
- p.Cys453Phe Single submitter ⚠
- p.Cys456Phe Single submitter ⚠
- p.Cys509Phe Single submitter ⚠
- p.Cys612Phe Single submitter ⚠
- p.Cys645Arg Single submitter ⚠
- p.Cys647Phe Single submitter ⚠
- p.Cys647Ser Single submitter ⚠
- p.Gln108Arg Single submitter ⚠
- p.Gln567His Single submitter ⚠
- p.Gln695Arg Single submitter ⚠
- p.Glu233Asp Single submitter ⚠
- p.Glu255Asp Single submitter ⚠
- p.Glu300Asp Single submitter ⚠
- p.Glu46Asp Single submitter ⚠
- p.Glu743Lys Single submitter ⚠
- p.Gly126Asp Single submitter ⚠
- p.Gly170Glu Single submitter ⚠
- p.Gly173Ser Single submitter ⚠
- p.Gly342Arg Single submitter ⚠
- p.Gly346Glu Single submitter ⚠
- p.Gly4Val Single submitter ⚠
- p.Gly523Ala Single submitter ⚠
- p.Gly542Trp Single submitter ⚠
- p.Gly650Glu Single submitter ⚠
- p.Gly741Asp Single submitter ⚠
- p.His641Gln Single submitter ⚠
- p.Ile19Val Single submitter ⚠
- p.Ile206Thr Single submitter ⚠
- p.Ile206Val Single submitter ⚠
- p.Ile292Met Single submitter ⚠
- p.Ile432Met Single submitter ⚠
- p.Ile579Thr Single submitter ⚠
- p.Ile597Met Single submitter ⚠
- p.Leu127Pro Single submitter ⚠
- p.Leu180Trp Single submitter ⚠
- p.Leu22Ile Single submitter ⚠
- p.Leu474Pro Single submitter ⚠
- p.Leu551Val Single submitter ⚠
- p.Leu70Phe Single submitter ⚠
- p.Lys115Asn Single submitter ⚠
- p.Lys157Asn Single submitter ⚠
- p.Lys278Glu Single submitter ⚠
- p.Lys501Arg Single submitter ⚠
- p.Lys625Gln Single submitter ⚠
- p.Met234Ile Single submitter ⚠
- p.Met254Thr Single submitter ⚠
- p.Met254Val Single submitter ⚠
- p.Met337Leu Single submitter ⚠
- p.Met506Ile Single submitter ⚠
- p.Met727Ile Single submitter ⚠
- p.Phe139Leu Single submitter ⚠
- p.Phe445Cys Single submitter ⚠
- p.Pro522Leu Single submitter ⚠
- p.Pro590Thr Single submitter ⚠
- p.Pro701Ala Single submitter ⚠
- p.Pro716Thr Single submitter ⚠
- p.Ser117Ala Single submitter ⚠
- p.Ser13Phe Single submitter ⚠
- p.Ser270Asn Single submitter ⚠
- p.Ser376Gly Single submitter ⚠
- p.Ser379Ile Single submitter ⚠
- p.Ser570Leu Single submitter ⚠
- p.Thr299Arg Single submitter ⚠
- p.Thr304Lys Single submitter ⚠
- p.Thr373Ile Single submitter ⚠
- p.Thr425Pro Single submitter ⚠
- p.Thr430Ala Single submitter ⚠
- p.Thr511Ile Single submitter ⚠
- p.Thr604Ala Single submitter ⚠
- p.Thr758Asn Single submitter ⚠
- p.Thr84Met Single submitter ⚠
- p.Thr96Ala Single submitter ⚠
- p.Trp176Cys Single submitter ⚠
- p.Trp651Cys Single submitter ⚠
- p.Tyr130Cys Single submitter ⚠
- p.Tyr370Cys Single submitter ⚠
- p.Tyr532Cys Single submitter ⚠
- p.Val306Leu Single submitter ⚠
- p.Val320Ile Single submitter ⚠
- p.Val661Met Single submitter ⚠