ADAM29 — 120 ClinVar variants
All ClinVar germline ADAM29 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 101 flagged for review →
20 Likely benign · 100 Uncertain significance
Full ADAM29 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 101
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM29 p.Ala314Glu Uncertain significance Single submitter
- ADAM29 p.Ala88Val Uncertain significance Single submitter
- ADAM29 p.Arg311His Uncertain significance Single submitter
- ADAM29 p.Arg501His Uncertain significance Single submitter
- ADAM29 p.Arg804Thr Uncertain significance Single submitter
- ADAM29 p.Asn652Lys Uncertain significance Single submitter
- ADAM29 p.Asp153Asn Uncertain significance Single submitter
- ADAM29 p.Asp433His Uncertain significance Single submitter
- ADAM29 p.Asp709His Uncertain significance Single submitter
- ADAM29 p.Cys173Tyr Uncertain significance Single submitter
- ADAM29 p.Cys437Tyr Uncertain significance Single submitter
- ADAM29 p.Gln282Pro Uncertain significance Single submitter
- ADAM29 p.Gln61Arg Uncertain significance Single submitter
- ADAM29 p.Gln769His Uncertain significance Single submitter
- ADAM29 p.Glu179Gly Uncertain significance Single submitter
- ADAM29 p.Glu380Lys Uncertain significance Single submitter
- ADAM29 p.Glu387Gln Uncertain significance Single submitter
- ADAM29 p.Glu727Gly Uncertain significance Single submitter
- ADAM29 p.Glu727Lys Uncertain significance Single submitter
- ADAM29 p.Gly104Arg Uncertain significance Single submitter
- ADAM29 p.Gly125Glu Uncertain significance Single submitter
- ADAM29 p.Gly45Ser Uncertain significance Single submitter
- ADAM29 p.His267Tyr Uncertain significance Single submitter
- ADAM29 p.His357Tyr Uncertain significance Single submitter
- ADAM29 p.His390Arg Uncertain significance Single submitter
- ADAM29 p.His390Gln Uncertain significance Single submitter
- ADAM29 p.His418Arg Uncertain significance Single submitter
- ADAM29 p.His640Tyr Uncertain significance Single submitter
- ADAM29 p.His641Leu Uncertain significance Single submitter
- ADAM29 p.Ile231Met Uncertain significance Single submitter
- ADAM29 p.Ile300Met Uncertain significance Single submitter
- ADAM29 p.Ile328Thr Uncertain significance Single submitter
- ADAM29 p.Ile328Val Uncertain significance Single submitter
- ADAM29 p.Ile655Lys Uncertain significance Single submitter
- ADAM29 p.Leu72Pro Uncertain significance Single submitter
- ADAM29 p.Leu78Ile Uncertain significance Single submitter
- ADAM29 p.Lys421Asn Uncertain significance Single submitter
- ADAM29 p.Lys705Glu Uncertain significance Single submitter
- ADAM29 p.Met152Lys Uncertain significance Single submitter
- ADAM29 p.Met306Val Uncertain significance Single submitter
- ADAM29 p.Ser370Asn Uncertain significance Single submitter
- ADAM29 p.Thr278Met Uncertain significance Single submitter
- ADAM29 p.Thr42Ala Uncertain significance Single submitter
- ADAM29 p.Thr712Ile Uncertain significance Single submitter
- ADAM29 p.Thr818Met Uncertain significance Single submitter
- ADAM29 p.Tyr377Phe Uncertain significance Single submitter
- ADAM29 p.Tyr646Phe Uncertain significance Single submitter
- ADAM29 p.Val227Ile Uncertain significance Single submitter
- ADAM29 p.Val258Ile Uncertain significance Single submitter
- ADAM29 p.Val69Ile Uncertain significance Single submitter
- ADAM29 p.Val736Leu Uncertain significance Single submitter
- ADAM29 p.Val772Leu Uncertain significance Single submitter
Predictors split 49
The independent predictors disagree with each other — read with care.
- ADAM29 p.Arg213Cys Uncertain significance Single submitter
- ADAM29 p.Arg530Cys Uncertain significance Single submitter
- ADAM29 p.Arg723Cys Uncertain significance Single submitter
- ADAM29 p.Asn502Lys Uncertain significance Single submitter
- ADAM29 p.Asn514Asp Uncertain significance Single submitter
- ADAM29 p.Asn631Lys Uncertain significance Single submitter
- ADAM29 p.Asn637Ile Uncertain significance Single submitter
- ADAM29 p.Gln758Arg Uncertain significance Single submitter
- ADAM29 p.Gln776Arg Uncertain significance Single submitter
- ADAM29 p.Gln794Arg Uncertain significance Single submitter
- ADAM29 p.Glu156Gly Uncertain significance Single submitter
- ADAM29 p.Gly296Arg Uncertain significance Single submitter
- ADAM29 p.His287Tyr Uncertain significance Single submitter
- ADAM29 p.His572Asp Uncertain significance Single submitter
- ADAM29 p.Ile228Thr Uncertain significance Single submitter
- ADAM29 p.Ile39Thr Uncertain significance Single submitter
- ADAM29 p.Ile508Ser Uncertain significance Single submitter
- ADAM29 p.Ile55Phe Uncertain significance Single submitter
- ADAM29 p.Ile65Phe Uncertain significance Single submitter
- ADAM29 p.Ile67Thr Uncertain significance Single submitter
- ADAM29 p.Ile681Thr Uncertain significance Single submitter
- ADAM29 p.Leu210Val Uncertain significance Single submitter
- ADAM29 p.Leu256Ile Uncertain significance Single submitter
- ADAM29 p.Leu441Phe Uncertain significance Single submitter
- ADAM29 p.Leu684Phe Uncertain significance Single submitter
- ADAM29 p.Lys543Asn Uncertain significance Single submitter
- ADAM29 p.Met809Arg Uncertain significance Single submitter
- ADAM29 p.Met809Ile Uncertain significance Single submitter
- ADAM29 p.Met809Lys Uncertain significance Single submitter
- ADAM29 p.Phe145Ser Uncertain significance Single submitter
- ADAM29 p.Pro309Leu Likely benign Single submitter
- ADAM29 p.Pro593Ala Uncertain significance Single submitter
- ADAM29 p.Pro734Thr Uncertain significance Single submitter
- ADAM29 p.Pro810Leu Uncertain significance Single submitter
- ADAM29 p.Ser298Asn Uncertain significance Single submitter
- ADAM29 p.Ser53Phe Uncertain significance Single submitter
- ADAM29 p.Ser757Phe Uncertain significance Single submitter
- ADAM29 p.Ser759Asn Uncertain significance Single submitter
- ADAM29 p.Ser768Gly Uncertain significance Single submitter
- ADAM29 p.Trp51Ser Uncertain significance Single submitter
- ADAM29 p.Trp573Cys Uncertain significance Single submitter
- ADAM29 p.Tyr377Cys Uncertain significance Single submitter
- ADAM29 p.Tyr480His Uncertain significance Single submitter
- ADAM29 p.Tyr678His Uncertain significance Single submitter
- ADAM29 p.Val616Ala Uncertain significance Single submitter
- ADAM29 p.Val736Ala Uncertain significance Single submitter
- ADAM29 p.Val754Ala Uncertain significance Single submitter
- ADAM29 p.Val772Met Uncertain significance Single submitter
- ADAM29 p.Val817Leu Uncertain significance Single submitter
All ADAM29 variants
Likely benign 20
- p.Arg213His Single submitter
- p.Arg723His Single submitter
- p.Arg724Gln Single submitter
- p.Arg724Pro Single submitter
- p.Glu155Lys Single submitter
- p.His390Tyr Single submitter
- p.His751Gln Single submitter
- p.Met3Val Single submitter
- p.Met755Thr Single submitter
- p.Phe688Leu Single submitter
- p.Pro309Leu Single submitter ⚠
- p.Pro747= Single submitter
- p.Pro765= Single submitter
- p.Ser757= Single submitter
- p.Ser768= Single submitter
- p.Ser775= Single submitter
- p.Thr764= Single submitter
- p.Thr818= Single submitter
- p.Val389Leu Single submitter
- p.Val549Ile Single submitter
Uncertain significance 100
- p.Ala314Glu Single submitter ⚠
- p.Ala88Val Single submitter ⚠
- p.Arg213Cys Single submitter ⚠
- p.Arg311His Single submitter ⚠
- p.Arg501His Single submitter ⚠
- p.Arg530Cys Single submitter ⚠
- p.Arg723Cys Single submitter ⚠
- p.Arg804Thr Single submitter ⚠
- p.Asn502Lys Single submitter ⚠
- p.Asn514Asp Single submitter ⚠
- p.Asn631Lys Single submitter ⚠
- p.Asn637Ile Single submitter ⚠
- p.Asn652Lys Single submitter ⚠
- p.Asp153Asn Single submitter ⚠
- p.Asp433His Single submitter ⚠
- p.Asp709His Single submitter ⚠
- p.Cys173Tyr Single submitter ⚠
- p.Cys437Tyr Single submitter ⚠
- p.Gln282Pro Single submitter ⚠
- p.Gln61Arg Single submitter ⚠
- p.Gln758Arg Single submitter ⚠
- p.Gln769His Single submitter ⚠
- p.Gln776Arg Single submitter ⚠
- p.Gln794Arg Single submitter ⚠
- p.Glu156Gly Single submitter ⚠
- p.Glu179Gly Single submitter ⚠
- p.Glu380Lys Single submitter ⚠
- p.Glu387Gln Single submitter ⚠
- p.Glu727Gly Single submitter ⚠
- p.Glu727Lys Single submitter ⚠
- p.Gly104Arg Single submitter ⚠
- p.Gly125Glu Single submitter ⚠
- p.Gly296Arg Single submitter ⚠
- p.Gly45Ser Single submitter ⚠
- p.His267Tyr Single submitter ⚠
- p.His287Tyr Single submitter ⚠
- p.His357Tyr Single submitter ⚠
- p.His390Arg Single submitter ⚠
- p.His390Gln Single submitter ⚠
- p.His418Arg Single submitter ⚠
- p.His572Asp Single submitter ⚠
- p.His640Tyr Single submitter ⚠
- p.His641Leu Single submitter ⚠
- p.Ile228Thr Single submitter ⚠
- p.Ile231Met Single submitter ⚠
- p.Ile300Met Single submitter ⚠
- p.Ile328Thr Single submitter ⚠
- p.Ile328Val Single submitter ⚠
- p.Ile39Thr Single submitter ⚠
- p.Ile508Ser Single submitter ⚠
- p.Ile55Phe Single submitter ⚠
- p.Ile655Lys Single submitter ⚠
- p.Ile65Phe Single submitter ⚠
- p.Ile67Thr Single submitter ⚠
- p.Ile681Thr Single submitter ⚠
- p.Leu210Val Single submitter ⚠
- p.Leu256Ile Single submitter ⚠
- p.Leu441Phe Single submitter ⚠
- p.Leu684Phe Single submitter ⚠
- p.Leu72Pro Single submitter ⚠
- p.Leu78Ile Single submitter ⚠
- p.Lys421Asn Single submitter ⚠
- p.Lys543Asn Single submitter ⚠
- p.Lys705Glu Single submitter ⚠
- p.Met152Lys Single submitter ⚠
- p.Met306Val Single submitter ⚠
- p.Met809Arg Single submitter ⚠
- p.Met809Ile Single submitter ⚠
- p.Met809Lys Single submitter ⚠
- p.Phe145Ser Single submitter ⚠
- p.Pro593Ala Single submitter ⚠
- p.Pro734Thr Single submitter ⚠
- p.Pro810Leu Single submitter ⚠
- p.Ser298Asn Single submitter ⚠
- p.Ser370Asn Single submitter ⚠
- p.Ser53Phe Single submitter ⚠
- p.Ser757Phe Single submitter ⚠
- p.Ser759Asn Single submitter ⚠
- p.Ser768Gly Single submitter ⚠
- p.Thr278Met Single submitter ⚠
- p.Thr42Ala Single submitter ⚠
- p.Thr712Ile Single submitter ⚠
- p.Thr818Met Single submitter ⚠
- p.Trp51Ser Single submitter ⚠
- p.Trp573Cys Single submitter ⚠
- p.Tyr377Cys Single submitter ⚠
- p.Tyr377Phe Single submitter ⚠
- p.Tyr480His Single submitter ⚠
- p.Tyr646Phe Single submitter ⚠
- p.Tyr678His Single submitter ⚠
- p.Val227Ile Single submitter ⚠
- p.Val258Ile Single submitter ⚠
- p.Val616Ala Single submitter ⚠
- p.Val69Ile Single submitter ⚠
- p.Val736Ala Single submitter ⚠
- p.Val736Leu Single submitter ⚠
- p.Val754Ala Single submitter ⚠
- p.Val772Leu Single submitter ⚠
- p.Val772Met Single submitter ⚠
- p.Val817Leu Single submitter ⚠