ADAM30 — 123 ClinVar variants
All ClinVar germline ADAM30 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 115 flagged for review →
10 Likely benign · 113 Uncertain significance
Full ADAM30 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 115
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM30 p.Ala518Pro Uncertain significance Single submitter
- ADAM30 p.Ala550Thr Uncertain significance Single submitter
- ADAM30 p.Arg245His Uncertain significance Single submitter
- ADAM30 p.Arg2Lys Uncertain significance Single submitter
- ADAM30 p.Arg367His Uncertain significance Single submitter
- ADAM30 p.Arg451His Uncertain significance Single submitter
- ADAM30 p.Arg494His Uncertain significance Single submitter
- ADAM30 p.Arg494Leu Uncertain significance Single submitter
- ADAM30 p.Arg497Gly Uncertain significance Single submitter
- ADAM30 p.Arg52Gln Uncertain significance Single submitter
- ADAM30 p.Arg641Pro Uncertain significance Single submitter
- ADAM30 p.Arg709Trp Uncertain significance Single submitter
- ADAM30 p.Arg779Gln Uncertain significance Single submitter
- ADAM30 p.Asn328Ser Uncertain significance Single submitter
- ADAM30 p.Asn438Lys Uncertain significance Single submitter
- ADAM30 p.Asn438Ser Uncertain significance Single submitter
- ADAM30 p.Asn622Ile Uncertain significance Single submitter
- ADAM30 p.Asn774Ser Uncertain significance Single submitter
- ADAM30 p.Asp349Val Uncertain significance Single submitter
- ADAM30 p.Asp524Asn Uncertain significance Single submitter
- ADAM30 p.Cys402Tyr Uncertain significance Single submitter
- ADAM30 p.Cys650Ser Uncertain significance Single submitter
- ADAM30 p.Gln170Glu Uncertain significance Single submitter
- ADAM30 p.Gln558Arg Uncertain significance Single submitter
- ADAM30 p.Gln630Arg Uncertain significance Single submitter
- ADAM30 p.Gln630His Uncertain significance Single submitter
- ADAM30 p.Glu37Val Uncertain significance Single submitter
- ADAM30 p.Gly173Ser Uncertain significance Single submitter
- ADAM30 p.Gly590Ser Uncertain significance Single submitter
- ADAM30 p.Gly758Val Uncertain significance Single submitter
- ADAM30 p.His103Arg Uncertain significance Single submitter
- ADAM30 p.His651Asp Uncertain significance Single submitter
- ADAM30 p.Ile126Val Uncertain significance Single submitter
- ADAM30 p.Ile179Met Uncertain significance Single submitter
- ADAM30 p.Ile406Val Uncertain significance Single submitter
- ADAM30 p.Ile441Val Uncertain significance Single submitter
- ADAM30 p.Ile553Val Uncertain significance Single submitter
- ADAM30 p.Ile560Val Uncertain significance Single submitter
- ADAM30 p.Ile574Val Uncertain significance Single submitter
- ADAM30 p.Ile682Phe Uncertain significance Single submitter
- ADAM30 p.Lys142Asn Uncertain significance Single submitter
- ADAM30 p.Lys200Gln Uncertain significance Single submitter
- ADAM30 p.Lys763Glu Uncertain significance Single submitter
- ADAM30 p.Met113Thr Uncertain significance Single submitter
- ADAM30 p.Met113Val Uncertain significance Single submitter
- ADAM30 p.Met130Ile Uncertain significance Single submitter
- ADAM30 p.Met130Val Uncertain significance Single submitter
- ADAM30 p.Met516Val Uncertain significance Single submitter
- ADAM30 p.Met585Thr Uncertain significance Single submitter
- ADAM30 p.Met598Leu Uncertain significance Single submitter
- ADAM30 p.Met598Val Uncertain significance Single submitter
- ADAM30 p.Met693Ile Uncertain significance Single submitter
- ADAM30 p.Phe619Leu Uncertain significance Single submitter
- ADAM30 p.Pro332Ser Uncertain significance Single submitter
- ADAM30 p.Pro724Thr Uncertain significance Single submitter
- ADAM30 p.Ser214Arg Uncertain significance Single submitter
- ADAM30 p.Ser50Asn Uncertain significance Single submitter
- ADAM30 p.Ser684Pro Uncertain significance Single submitter
- ADAM30 p.Ser777Gly Uncertain significance Single submitter
- ADAM30 p.Thr368Asn Uncertain significance Single submitter
- ADAM30 p.Thr640Ala Uncertain significance Single submitter
- ADAM30 p.Tyr266Asn Uncertain significance Single submitter
- ADAM30 p.Tyr279His Uncertain significance Single submitter
- ADAM30 p.Val219Met Uncertain significance Single submitter
- ADAM30 p.Val244Ile Uncertain significance Single submitter
- ADAM30 p.Val264Ile Uncertain significance Single submitter
- ADAM30 p.Val55Gly Uncertain significance Single submitter
Predictors split 48
The independent predictors disagree with each other — read with care.
- ADAM30 p.Ala124Ser Uncertain significance Single submitter
- ADAM30 p.Ala230Thr Uncertain significance Single submitter
- ADAM30 p.Arg215Gly Uncertain significance Single submitter
- ADAM30 p.Arg275Thr Uncertain significance Single submitter
- ADAM30 p.Arg287His Uncertain significance Single submitter
- ADAM30 p.Arg449Trp Uncertain significance Single submitter
- ADAM30 p.Asn220Asp Uncertain significance Single submitter
- ADAM30 p.Asn625Asp Uncertain significance Single submitter
- ADAM30 p.Asp121Tyr Uncertain significance Single submitter
- ADAM30 p.Asp424Glu Uncertain significance Single submitter
- ADAM30 p.Cys172Phe Uncertain significance Single submitter
- ADAM30 p.Gln225His Uncertain significance Single submitter
- ADAM30 p.Gln750Arg Uncertain significance Single submitter
- ADAM30 p.Glu411Lys Uncertain significance Single submitter
- ADAM30 p.Glu412Asp Uncertain significance Single submitter
- ADAM30 p.Glu419Ala Uncertain significance Single submitter
- ADAM30 p.Glu733Lys Uncertain significance Single submitter
- ADAM30 p.Glu769Lys Uncertain significance Single submitter
- ADAM30 p.Glu770Gly Uncertain significance Single submitter
- ADAM30 p.Gly310Ala Uncertain significance Single submitter
- ADAM30 p.Gly454Arg Uncertain significance Single submitter
- ADAM30 p.Gly604Ser Uncertain significance Single submitter
- ADAM30 p.Gly609Ala Uncertain significance Single submitter
- ADAM30 p.His592Asn Uncertain significance Single submitter
- ADAM30 p.Ile406Thr Uncertain significance Single submitter
- ADAM30 p.Ile692Met Likely benign Single submitter
- ADAM30 p.Lys123Glu Likely benign Single submitter
- ADAM30 p.Lys621Glu Uncertain significance Single submitter
- ADAM30 p.Lys783Asn Uncertain significance Single submitter
- ADAM30 p.Phe137Cys Uncertain significance Single submitter
- ADAM30 p.Pro107Gln Uncertain significance Single submitter
- ADAM30 p.Pro46Leu Uncertain significance Single submitter
- ADAM30 p.Pro488Thr Uncertain significance Single submitter
- ADAM30 p.Pro566Ser Uncertain significance Single submitter
- ADAM30 p.Pro79His Uncertain significance Single submitter
- ADAM30 p.Ser453Pro Uncertain significance Single submitter
- ADAM30 p.Ser474Leu Uncertain significance Single submitter
- ADAM30 p.Ser474Thr Uncertain significance Single submitter
- ADAM30 p.Ser552Leu Uncertain significance Single submitter
- ADAM30 p.Ser627Ala Uncertain significance Single submitter
- ADAM30 p.Ser753Pro Uncertain significance Single submitter
- ADAM30 p.Thr20Lys Uncertain significance Single submitter
- ADAM30 p.Thr589Ala Uncertain significance Single submitter
- ADAM30 p.Thr730Pro Uncertain significance Single submitter
- ADAM30 p.Tyr469Cys Uncertain significance Single submitter
- ADAM30 p.Tyr591Cys Uncertain significance Single submitter
- ADAM30 p.Tyr64Cys Uncertain significance Single submitter
- ADAM30 p.Val116Met Uncertain significance Single submitter
All ADAM30 variants
Likely benign 10
- p.Glu118Gly Single submitter
- p.Glu420Asp Single submitter
- p.Glu563Lys Single submitter
- p.Gly97= Single submitter
- p.Ile692Met Single submitter ⚠
- p.Leu232Ile Single submitter
- p.Lys123Glu Single submitter ⚠
- p.Ser684Leu Single submitter
- p.Val264Leu Single submitter
- p.Val740Gly Single submitter
Uncertain significance 113
- p.Ala124Ser Single submitter ⚠
- p.Ala230Thr Single submitter ⚠
- p.Ala518Pro Single submitter ⚠
- p.Ala550Thr Single submitter ⚠
- p.Arg215Gly Single submitter ⚠
- p.Arg245His Single submitter ⚠
- p.Arg275Thr Single submitter ⚠
- p.Arg287His Single submitter ⚠
- p.Arg2Lys Single submitter ⚠
- p.Arg367His Single submitter ⚠
- p.Arg449Trp Single submitter ⚠
- p.Arg451His Single submitter ⚠
- p.Arg494His Single submitter ⚠
- p.Arg494Leu Single submitter ⚠
- p.Arg497Gly Single submitter ⚠
- p.Arg52Gln Single submitter ⚠
- p.Arg641Pro Single submitter ⚠
- p.Arg709Trp Single submitter ⚠
- p.Arg779Gln Single submitter ⚠
- p.Asn220Asp Single submitter ⚠
- p.Asn328Ser Single submitter ⚠
- p.Asn438Lys Single submitter ⚠
- p.Asn438Ser Single submitter ⚠
- p.Asn622Ile Single submitter ⚠
- p.Asn625Asp Single submitter ⚠
- p.Asn774Ser Single submitter ⚠
- p.Asp121Tyr Single submitter ⚠
- p.Asp349Val Single submitter ⚠
- p.Asp424Glu Single submitter ⚠
- p.Asp524Asn Single submitter ⚠
- p.Cys172Phe Single submitter ⚠
- p.Cys402Tyr Single submitter ⚠
- p.Cys650Ser Single submitter ⚠
- p.Gln170Glu Single submitter ⚠
- p.Gln225His Single submitter ⚠
- p.Gln558Arg Single submitter ⚠
- p.Gln630Arg Single submitter ⚠
- p.Gln630His Single submitter ⚠
- p.Gln750Arg Single submitter ⚠
- p.Glu37Val Single submitter ⚠
- p.Glu411Lys Single submitter ⚠
- p.Glu412Asp Single submitter ⚠
- p.Glu419Ala Single submitter ⚠
- p.Glu733Lys Single submitter ⚠
- p.Glu769Lys Single submitter ⚠
- p.Glu770Gly Single submitter ⚠
- p.Gly173Ser Single submitter ⚠
- p.Gly310Ala Single submitter ⚠
- p.Gly454Arg Single submitter ⚠
- p.Gly590Ser Single submitter ⚠
- p.Gly604Ser Single submitter ⚠
- p.Gly609Ala Single submitter ⚠
- p.Gly758Val Single submitter ⚠
- p.His103Arg Single submitter ⚠
- p.His592Asn Single submitter ⚠
- p.His651Asp Single submitter ⚠
- p.Ile126Val Single submitter ⚠
- p.Ile179Met Single submitter ⚠
- p.Ile406Thr Single submitter ⚠
- p.Ile406Val Single submitter ⚠
- p.Ile441Val Single submitter ⚠
- p.Ile553Val Single submitter ⚠
- p.Ile560Val Single submitter ⚠
- p.Ile574Val Single submitter ⚠
- p.Ile682Phe Single submitter ⚠
- p.Lys142Asn Single submitter ⚠
- p.Lys200Gln Single submitter ⚠
- p.Lys621Glu Single submitter ⚠
- p.Lys763Glu Single submitter ⚠
- p.Lys783Asn Single submitter ⚠
- p.Met113Thr Single submitter ⚠
- p.Met113Val Single submitter ⚠
- p.Met130Ile Single submitter ⚠
- p.Met130Val Single submitter ⚠
- p.Met516Val Single submitter ⚠
- p.Met585Thr Single submitter ⚠
- p.Met598Leu Single submitter ⚠
- p.Met598Val Single submitter ⚠
- p.Met693Ile Single submitter ⚠
- p.Phe137Cys Single submitter ⚠
- p.Phe619Leu Single submitter ⚠
- p.Pro107Gln Single submitter ⚠
- p.Pro332Ser Single submitter ⚠
- p.Pro46Leu Single submitter ⚠
- p.Pro488Thr Single submitter ⚠
- p.Pro566Ser Single submitter ⚠
- p.Pro724Thr Single submitter ⚠
- p.Pro79His Single submitter ⚠
- p.Ser214Arg Single submitter ⚠
- p.Ser453Pro Single submitter ⚠
- p.Ser474Leu Single submitter ⚠
- p.Ser474Thr Single submitter ⚠
- p.Ser50Asn Single submitter ⚠
- p.Ser552Leu Single submitter ⚠
- p.Ser627Ala Single submitter ⚠
- p.Ser684Pro Single submitter ⚠
- p.Ser753Pro Single submitter ⚠
- p.Ser777Gly Single submitter ⚠
- p.Thr20Lys Single submitter ⚠
- p.Thr368Asn Single submitter ⚠
- p.Thr589Ala Single submitter ⚠
- p.Thr640Ala Single submitter ⚠
- p.Thr730Pro Single submitter ⚠
- p.Tyr266Asn Single submitter ⚠
- p.Tyr279His Single submitter ⚠
- p.Tyr469Cys Single submitter ⚠
- p.Tyr591Cys Single submitter ⚠
- p.Tyr64Cys Single submitter ⚠
- p.Val116Met Single submitter ⚠
- p.Val219Met Single submitter ⚠
- p.Val244Ile Single submitter ⚠
- p.Val264Ile Single submitter ⚠
- p.Val55Gly Single submitter ⚠