ADAM33 — 132 ClinVar variants
All ClinVar germline ADAM33 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 116 flagged for review →
1 Conflicting · 8 Benign · 13 Likely benign · 110 Uncertain significance
Full ADAM33 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 116
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 58
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM33 p.Ala305Thr Uncertain significance Single submitter
- ADAM33 p.Ala408Val Uncertain significance Single submitter
- ADAM33 p.Ala518Thr Uncertain significance Single submitter
- ADAM33 p.Ala540Val Uncertain significance Single submitter
- ADAM33 p.Arg398Leu Uncertain significance Single submitter
- ADAM33 p.Arg440Gly Uncertain significance Single submitter
- ADAM33 p.Arg52Leu Uncertain significance Single submitter
- ADAM33 p.Arg726Gln Uncertain significance Single submitter
- ADAM33 p.Asp356Asn Uncertain significance Single submitter
- ADAM33 p.Asp47Gly Uncertain significance Single submitter
- ADAM33 p.Asp483Glu Uncertain significance Single submitter
- ADAM33 p.Asp700Val Uncertain significance Single submitter
- ADAM33 p.Cys420Arg Uncertain significance Single submitter
- ADAM33 p.Gln171Pro Uncertain significance Single submitter
- ADAM33 p.Gln524His Uncertain significance Single submitter
- ADAM33 p.Gln528Leu Uncertain significance Single submitter
- ADAM33 p.Gln695Pro Uncertain significance Single submitter
- ADAM33 p.Glu165Gln Uncertain significance Single submitter
- ADAM33 p.Glu429Gly Uncertain significance Single submitter
- ADAM33 p.Glu539Lys Uncertain significance Single submitter
- ADAM33 p.Glu765Asp Uncertain significance Single submitter
- ADAM33 p.Glu790Ala Uncertain significance Single submitter
- ADAM33 p.Gly201Ser Uncertain significance Single submitter
- ADAM33 p.Gly326Glu Uncertain significance Single submitter
- ADAM33 p.Gly378Arg Uncertain significance Single submitter
- ADAM33 p.Gly400Trp Uncertain significance Single submitter
- ADAM33 p.Gly661Trp Uncertain significance Single submitter
- ADAM33 p.Gly738Ser Uncertain significance Single submitter
- ADAM33 p.His232Arg Uncertain significance Single submitter
- ADAM33 p.His345Arg Uncertain significance Single submitter
- ADAM33 p.His788Arg Uncertain significance Single submitter
- ADAM33 p.Ile216Leu Uncertain significance Single submitter
- ADAM33 p.Ile216Val Uncertain significance Single submitter
- ADAM33 p.Ile35Val Uncertain significance Single submitter
- ADAM33 p.Leu212Arg Uncertain significance Single submitter
- ADAM33 p.Leu419Pro Uncertain significance Single submitter
- ADAM33 p.Leu502Pro Uncertain significance Single submitter
- ADAM33 p.Leu727Arg Uncertain significance Single submitter
- ADAM33 p.Leu78Val Uncertain significance Single submitter
- ADAM33 p.Lys682Thr Uncertain significance Single submitter
- ADAM33 p.Met169Val Uncertain significance Single submitter
- ADAM33 p.Met479Thr Uncertain significance Single submitter
- ADAM33 p.Met706Ile Uncertain significance Single submitter
- ADAM33 p.Pro520Ser Uncertain significance Single submitter
- ADAM33 p.Pro757Arg Uncertain significance Single submitter
- ADAM33 p.Pro800Thr Uncertain significance Single submitter
- ADAM33 p.Ser134Ala Uncertain significance Single submitter
- ADAM33 p.Ser192Arg Uncertain significance Single submitter
- ADAM33 p.Ser350Gly Uncertain significance Single submitter
- ADAM33 p.Ser559Arg Uncertain significance Single submitter
- ADAM33 p.Ser559Ile Uncertain significance Single submitter
- ADAM33 p.Ser786Cys Uncertain significance Single submitter
- ADAM33 p.Thr225Ser Uncertain significance Single submitter
- ADAM33 p.Thr489Ala Uncertain significance Single submitter
- ADAM33 p.Trp23Arg Uncertain significance Single submitter
- ADAM33 p.Val328Met Uncertain significance Single submitter
- ADAM33 p.Val362Met Uncertain significance Single submitter
- ADAM33 p.Val710Ile Uncertain significance No assertion criteria
Predictors split 58
The independent predictors disagree with each other — read with care.
- ADAM33 p.Ala395Val Likely benign Multiple submitters
- ADAM33 p.Asn109Ser Benign Multiple submitters
- ADAM33 p.Ala241Gly Uncertain significance Single submitter
- ADAM33 p.Ala241Ser Uncertain significance Single submitter
- ADAM33 p.Ala241Thr Uncertain significance Single submitter
- ADAM33 p.Ala281Val Uncertain significance Single submitter
- ADAM33 p.Ala322Thr Uncertain significance Single submitter
- ADAM33 p.Ala455Thr Uncertain significance Single submitter
- ADAM33 p.Ala458Thr Likely benign Single submitter
- ADAM33 p.Ala518Pro Uncertain significance Single submitter
- ADAM33 p.Ala548Glu Uncertain significance Single submitter
- ADAM33 p.Ala609Gly Uncertain significance Single submitter
- ADAM33 p.Arg151Cys Uncertain significance Single submitter
- ADAM33 p.Arg168Gln Uncertain significance Single submitter
- ADAM33 p.Arg168Trp Uncertain significance Single submitter
- ADAM33 p.Arg203Gln Uncertain significance Single submitter
- ADAM33 p.Arg236Gly Uncertain significance Single submitter
- ADAM33 p.Arg266Trp Uncertain significance Single submitter
- ADAM33 p.Arg270Cys Uncertain significance Single submitter
- ADAM33 p.Arg293Pro Uncertain significance Single submitter
- ADAM33 p.Arg452Pro Uncertain significance Single submitter
- ADAM33 p.Arg607Gln Uncertain significance Single submitter
- ADAM33 p.Arg607Trp Uncertain significance Single submitter
- ADAM33 p.Arg652Leu Uncertain significance Single submitter
- ADAM33 p.Arg734Gln Likely benign Single submitter
- ADAM33 p.Asp125Asn Likely benign Single submitter
- ADAM33 p.Asp461Asn Uncertain significance Single submitter
- ADAM33 p.Gln602Leu Uncertain significance Single submitter
- ADAM33 p.Glu80Gln Uncertain significance Single submitter
- ADAM33 p.Gly135Arg Uncertain significance Single submitter
- ADAM33 p.Gly400Arg Uncertain significance Single submitter
- ADAM33 p.Gly401Asp Uncertain significance Single submitter
- ADAM33 p.Gly423Arg Uncertain significance Single submitter
- ADAM33 p.Gly454Glu Uncertain significance Single submitter
- ADAM33 p.Gly480Ser Uncertain significance Single submitter
- ADAM33 p.Gly504Asp Uncertain significance Single submitter
- ADAM33 p.Gly581Arg Uncertain significance Single submitter
- ADAM33 p.Gly719Ser Uncertain significance Single submitter
- ADAM33 p.Gly74Cys Uncertain significance Single submitter
- ADAM33 p.His332Tyr Uncertain significance Single submitter
- ADAM33 p.His562Asp Uncertain significance Single submitter
- ADAM33 p.Leu289Pro Uncertain significance Single submitter
- ADAM33 p.Leu351Phe Uncertain significance Single submitter
- ADAM33 p.Leu353Phe Uncertain significance Single submitter
- ADAM33 p.Leu419Phe Uncertain significance Single submitter
- ADAM33 p.Leu708His Uncertain significance Single submitter
- ADAM33 p.Pro409Ala Uncertain significance Single submitter
- ADAM33 p.Pro506Arg Uncertain significance Single submitter
- ADAM33 p.Pro506Thr Uncertain significance Single submitter
- ADAM33 p.Ser269Asn Uncertain significance Single submitter
- ADAM33 p.Thr250Ile Uncertain significance Single submitter
- ADAM33 p.Thr701Asn Conflicting Single submitter
- ADAM33 p.Thr95Ile Uncertain significance Single submitter
- ADAM33 p.Trp722Cys Uncertain significance Single submitter
- ADAM33 p.Val244Met Uncertain significance Single submitter
- ADAM33 p.Val40Ile Uncertain significance Single submitter
- ADAM33 p.Val545Leu Uncertain significance Single submitter
- ADAM33 p.Val636Met Uncertain significance Single submitter
All ADAM33 variants
Conflicting classifications of pathogenicity 1
- p.Thr701Asn Single submitter ⚠
Benign 8
- p.Asn109Ser Multiple submitters ⚠
- p.Gln804fs Multiple submitters
- p.Gly454= Multiple submitters
- p.Met590Val Multiple submitters
- p.Trp515Arg Multiple submitters
- p.Val499= Multiple submitters
- c.1402-7_1402-3del Single submitter
- p.Gly760= Single submitter
Likely benign 13
- p.Ala395Val Multiple submitters ⚠
- p.Ala458Thr Single submitter ⚠
- p.Arg151His Single submitter
- p.Arg156Gln Single submitter
- p.Arg52His Single submitter
- p.Arg734Gln Single submitter ⚠
- p.Asp125Asn Single submitter ⚠
- p.Cys420= Single submitter
- p.Gln292Arg Single submitter
- p.His756= Single submitter
- p.Lys210Arg Single submitter
- p.Pro414Leu Single submitter
- p.Ser61Leu Single submitter
Uncertain significance 110
- p.Ala241Gly Single submitter ⚠
- p.Ala241Ser Single submitter ⚠
- p.Ala241Thr Single submitter ⚠
- p.Ala281Val Single submitter ⚠
- p.Ala305Thr Single submitter ⚠
- p.Ala322Thr Single submitter ⚠
- p.Ala408Val Single submitter ⚠
- p.Ala455Thr Single submitter ⚠
- p.Ala518Pro Single submitter ⚠
- p.Ala518Thr Single submitter ⚠
- p.Ala540Val Single submitter ⚠
- p.Ala548Glu Single submitter ⚠
- p.Ala609Gly Single submitter ⚠
- p.Arg151Cys Single submitter ⚠
- p.Arg168Gln Single submitter ⚠
- p.Arg168Trp Single submitter ⚠
- p.Arg203Gln Single submitter ⚠
- p.Arg236Gly Single submitter ⚠
- p.Arg266Trp Single submitter ⚠
- p.Arg270Cys Single submitter ⚠
- p.Arg293Pro Single submitter ⚠
- p.Arg398Leu Single submitter ⚠
- p.Arg440Gly Single submitter ⚠
- p.Arg452Pro Single submitter ⚠
- p.Arg52Leu Single submitter ⚠
- p.Arg607Gln Single submitter ⚠
- p.Arg607Trp Single submitter ⚠
- p.Arg652Leu Single submitter ⚠
- p.Arg726Gln Single submitter ⚠
- p.Asp356Asn Single submitter ⚠
- p.Asp461Asn Single submitter ⚠
- p.Asp47Gly Single submitter ⚠
- p.Asp483Glu Single submitter ⚠
- p.Asp700Val Single submitter ⚠
- p.Cys420Arg Single submitter ⚠
- p.Gln171Pro Single submitter ⚠
- p.Gln524His Single submitter ⚠
- p.Gln528Leu Single submitter ⚠
- p.Gln602Leu Single submitter ⚠
- p.Gln695Pro Single submitter ⚠
- p.Glu165Gln Single submitter ⚠
- p.Glu429Gly Single submitter ⚠
- p.Glu539Lys Single submitter ⚠
- p.Glu765Asp Single submitter ⚠
- p.Glu790Ala Single submitter ⚠
- p.Glu80Gln Single submitter ⚠
- p.Gly135Arg Single submitter ⚠
- p.Gly201Ser Single submitter ⚠
- p.Gly326Glu Single submitter ⚠
- p.Gly378Arg Single submitter ⚠
- p.Gly400Arg Single submitter ⚠
- p.Gly400Trp Single submitter ⚠
- p.Gly401Asp Single submitter ⚠
- p.Gly423Arg Single submitter ⚠
- p.Gly454Glu Single submitter ⚠
- p.Gly480Ser Single submitter ⚠
- p.Gly504Asp Single submitter ⚠
- p.Gly581Arg Single submitter ⚠
- p.Gly661Trp Single submitter ⚠
- p.Gly719Ser Single submitter ⚠
- p.Gly738Ser Single submitter ⚠
- p.Gly74Cys Single submitter ⚠
- p.His232Arg Single submitter ⚠
- p.His332Tyr Single submitter ⚠
- p.His345Arg Single submitter ⚠
- p.His562Asp Single submitter ⚠
- p.His788Arg Single submitter ⚠
- p.Ile216Leu Single submitter ⚠
- p.Ile216Val Single submitter ⚠
- p.Ile35Val Single submitter ⚠
- p.Leu212Arg Single submitter ⚠
- p.Leu289Pro Single submitter ⚠
- p.Leu351Phe Single submitter ⚠
- p.Leu353Phe Single submitter ⚠
- p.Leu419Phe Single submitter ⚠
- p.Leu419Pro Single submitter ⚠
- p.Leu502Pro Single submitter ⚠
- p.Leu708His Single submitter ⚠
- p.Leu727Arg Single submitter ⚠
- p.Leu78Val Single submitter ⚠
- p.Lys682Thr Single submitter ⚠
- p.Met169Val Single submitter ⚠
- p.Met479Thr Single submitter ⚠
- p.Met706Ile Single submitter ⚠
- p.Pro409Ala Single submitter ⚠
- p.Pro506Arg Single submitter ⚠
- p.Pro506Thr Single submitter ⚠
- p.Pro520Ser Single submitter ⚠
- p.Pro757Arg Single submitter ⚠
- p.Pro800Thr Single submitter ⚠
- p.Ser134Ala Single submitter ⚠
- p.Ser192Arg Single submitter ⚠
- p.Ser269Asn Single submitter ⚠
- p.Ser350Gly Single submitter ⚠
- p.Ser559Arg Single submitter ⚠
- p.Ser559Ile Single submitter ⚠
- p.Ser786Cys Single submitter ⚠
- p.Thr225Ser Single submitter ⚠
- p.Thr250Ile Single submitter ⚠
- p.Thr489Ala Single submitter ⚠
- p.Thr95Ile Single submitter ⚠
- p.Trp23Arg Single submitter ⚠
- p.Trp722Cys Single submitter ⚠
- p.Val244Met Single submitter ⚠
- p.Val328Met Single submitter ⚠
- p.Val362Met Single submitter ⚠
- p.Val40Ile Single submitter ⚠
- p.Val545Leu Single submitter ⚠
- p.Val636Met Single submitter ⚠
- p.Val710Ile No assertion criteria ⚠