ADAM7 — 133 ClinVar variants
All ClinVar germline ADAM7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 125 flagged for review →
1 Benign · 8 Likely benign · 124 Uncertain significance
Full ADAM7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 125
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 77
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM7 p.Ala659Ser Uncertain significance Single submitter
- ADAM7 p.Ala739Thr Uncertain significance Single submitter
- ADAM7 p.Ala747Thr Uncertain significance Single submitter
- ADAM7 p.Arg225Gly Uncertain significance Single submitter
- ADAM7 p.Arg486Lys Uncertain significance Single submitter
- ADAM7 p.Asn167Lys Uncertain significance Single submitter
- ADAM7 p.Asn541Ser Uncertain significance Single submitter
- ADAM7 p.Asn544Lys Uncertain significance Single submitter
- ADAM7 p.Asn623Lys Uncertain significance Single submitter
- ADAM7 p.Asn632Ile Uncertain significance Single submitter
- ADAM7 p.Asn640His Uncertain significance Single submitter
- ADAM7 p.Asp183His Uncertain significance Single submitter
- ADAM7 p.Asp197Tyr Uncertain significance Single submitter
- ADAM7 p.Asp346Glu Uncertain significance Single submitter
- ADAM7 p.Asp417Asn Uncertain significance Single submitter
- ADAM7 p.Asp483Val Uncertain significance Single submitter
- ADAM7 p.Cys170Gly Uncertain significance Single submitter
- ADAM7 p.Cys389Tyr Uncertain significance Single submitter
- ADAM7 p.Cys428Tyr Uncertain significance Single submitter
- ADAM7 p.Cys442Tyr Uncertain significance Single submitter
- ADAM7 p.Cys499Ser Uncertain significance Single submitter
- ADAM7 p.Cys556Tyr Uncertain significance Single submitter
- ADAM7 p.Cys695Tyr Uncertain significance Single submitter
- ADAM7 p.Gln452Glu Uncertain significance Single submitter
- ADAM7 p.Gln510His Uncertain significance Single submitter
- ADAM7 p.Gln721His Uncertain significance Single submitter
- ADAM7 p.Gln722Glu Uncertain significance Single submitter
- ADAM7 p.Gln751Arg Uncertain significance Single submitter
- ADAM7 p.Glu25Asp Uncertain significance Single submitter
- ADAM7 p.Glu412Asp Uncertain significance Single submitter
- ADAM7 p.Glu550Lys Uncertain significance Single submitter
- ADAM7 p.Glu652Asp Uncertain significance Single submitter
- ADAM7 p.Glu661Lys Uncertain significance Single submitter
- ADAM7 p.Glu79Val Uncertain significance Single submitter
- ADAM7 p.Gly4Arg Uncertain significance Single submitter
- ADAM7 p.Gly533Arg Uncertain significance Single submitter
- ADAM7 p.Gly537Val Uncertain significance Single submitter
- ADAM7 p.Gly571Ala Uncertain significance Single submitter
- ADAM7 p.His115Asp Uncertain significance Single submitter
- ADAM7 p.His596Asn Uncertain significance Single submitter
- ADAM7 p.Ile123Val Uncertain significance Single submitter
- ADAM7 p.Ile264Thr Uncertain significance Single submitter
- ADAM7 p.Ile328Leu Uncertain significance Single submitter
- ADAM7 p.Ile329Thr Uncertain significance Single submitter
- ADAM7 p.Ile393Thr Uncertain significance Single submitter
- ADAM7 p.Ile592Leu Uncertain significance Single submitter
- ADAM7 p.Ile696Val Uncertain significance Single submitter
- ADAM7 p.Ile6Thr Uncertain significance Single submitter
- ADAM7 p.Ile728Asn Uncertain significance Single submitter
- ADAM7 p.Ile728Met Uncertain significance Single submitter
- ADAM7 p.Leu11Ser Uncertain significance Single submitter
- ADAM7 p.Leu22Phe Uncertain significance Single submitter
- ADAM7 p.Leu291Ile Uncertain significance Single submitter
- ADAM7 p.Leu296Phe Uncertain significance Single submitter
- ADAM7 p.Leu566Phe Uncertain significance Single submitter
- ADAM7 p.Leu729Gln Uncertain significance Single submitter
- ADAM7 p.Lys191Glu Uncertain significance Single submitter
- ADAM7 p.Lys455Arg Uncertain significance Single submitter
- ADAM7 p.Lys590Arg Uncertain significance Single submitter
- ADAM7 p.Lys714Ile Uncertain significance Single submitter
- ADAM7 p.Lys93Asn Uncertain significance Single submitter
- ADAM7 p.Met104Val Uncertain significance Single submitter
- ADAM7 p.Met501Thr Uncertain significance Single submitter
- ADAM7 p.Met624Val Uncertain significance Single submitter
- ADAM7 p.Phe370Leu Uncertain significance Single submitter
- ADAM7 p.Pro163Leu Uncertain significance Single submitter
- ADAM7 p.Pro738Leu Uncertain significance Single submitter
- ADAM7 p.Ser512Phe Uncertain significance Single submitter
- ADAM7 p.Thr441Ile Uncertain significance Single submitter
- ADAM7 p.Thr46Ile Uncertain significance Single submitter
- ADAM7 p.Thr46Pro Uncertain significance Single submitter
- ADAM7 p.Tyr147His Uncertain significance Single submitter
- ADAM7 p.Tyr385Cys Uncertain significance Single submitter
- ADAM7 p.Val247Ile Uncertain significance Single submitter
- ADAM7 p.Val288Phe Uncertain significance Single submitter
- ADAM7 p.Val289Ile Uncertain significance Single submitter
- ADAM7 p.Val604Leu Uncertain significance Single submitter
Predictors split 48
The independent predictors disagree with each other — read with care.
- ADAM7 p.Ala207Val Uncertain significance Single submitter
- ADAM7 p.Ala456Val Uncertain significance Single submitter
- ADAM7 p.Ala463Glu Uncertain significance Single submitter
- ADAM7 p.Arg270Cys Uncertain significance Single submitter
- ADAM7 p.Arg282Gln Uncertain significance Single submitter
- ADAM7 p.Arg486Gly Uncertain significance Single submitter
- ADAM7 p.Arg507Cys Uncertain significance Single submitter
- ADAM7 p.Arg507Leu Uncertain significance Single submitter
- ADAM7 p.Arg507Pro Uncertain significance Single submitter
- ADAM7 p.Arg691His Uncertain significance Single submitter
- ADAM7 p.Arg693Gln Likely benign Single submitter
- ADAM7 p.Asn174Ile Uncertain significance Single submitter
- ADAM7 p.Asp430Glu Uncertain significance Single submitter
- ADAM7 p.Cys492Tyr Uncertain significance Single submitter
- ADAM7 p.Glu446Gly Uncertain significance Single submitter
- ADAM7 p.Glu449Lys Uncertain significance Single submitter
- ADAM7 p.Gly293Arg Uncertain significance Single submitter
- ADAM7 p.Gly307Arg Uncertain significance Single submitter
- ADAM7 p.Gly607Arg Uncertain significance Single submitter
- ADAM7 p.Gly613Arg Uncertain significance Single submitter
- ADAM7 p.Gly684Arg Uncertain significance Single submitter
- ADAM7 p.Gly715Val Uncertain significance Single submitter
- ADAM7 p.Ile195Thr Uncertain significance Single submitter
- ADAM7 p.Ile242Asn Uncertain significance Single submitter
- ADAM7 p.Ile258Met Uncertain significance Single submitter
- ADAM7 p.Ile680Thr Uncertain significance Single submitter
- ADAM7 p.Leu268Phe Uncertain significance Single submitter
- ADAM7 p.Leu570Arg Uncertain significance Single submitter
- ADAM7 p.Leu59Phe Uncertain significance Single submitter
- ADAM7 p.Leu60Val Uncertain significance Single submitter
- ADAM7 p.Leu676Phe Uncertain significance Single submitter
- ADAM7 p.Met343Ile Uncertain significance Single submitter
- ADAM7 p.Phe132Leu Uncertain significance Single submitter
- ADAM7 p.Phe133Leu Uncertain significance Single submitter
- ADAM7 p.Phe500Leu Uncertain significance Single submitter
- ADAM7 p.Pro101Thr Uncertain significance Single submitter
- ADAM7 p.Pro366Ser Uncertain significance Single submitter
- ADAM7 p.Pro581Thr Uncertain significance Single submitter
- ADAM7 p.Ser112Cys Uncertain significance Single submitter
- ADAM7 p.Ser262Ala Uncertain significance Single submitter
- ADAM7 p.Ser522Asn Uncertain significance Single submitter
- ADAM7 p.Thr425Ile Uncertain significance Single submitter
- ADAM7 p.Thr591Ile Uncertain significance Single submitter
- ADAM7 p.Tyr628His Uncertain significance Single submitter
- ADAM7 p.Val300Met Uncertain significance Single submitter
- ADAM7 p.Val627Ile Uncertain significance Single submitter
- ADAM7 p.Val675Ala Uncertain significance Single submitter
- ADAM7 p.Val71Ala Uncertain significance Single submitter
All ADAM7 variants
Benign 1
- c.633+3318dup Single submitter
Likely benign 8
- p.Arg31His Single submitter
- p.Arg693Gln Single submitter ⚠
- p.Asn617Ser Single submitter
- p.Glu62= Single submitter
- p.Leu391Phe Single submitter
- p.Ser606Pro Single submitter
- p.Val615= Single submitter
- p.Val681Ile Single submitter
Uncertain significance 124
- p.Ala207Val Single submitter ⚠
- p.Ala456Val Single submitter ⚠
- p.Ala463Glu Single submitter ⚠
- p.Ala659Ser Single submitter ⚠
- p.Ala739Thr Single submitter ⚠
- p.Ala747Thr Single submitter ⚠
- p.Arg225Gly Single submitter ⚠
- p.Arg270Cys Single submitter ⚠
- p.Arg282Gln Single submitter ⚠
- p.Arg486Gly Single submitter ⚠
- p.Arg486Lys Single submitter ⚠
- p.Arg507Cys Single submitter ⚠
- p.Arg507Leu Single submitter ⚠
- p.Arg507Pro Single submitter ⚠
- p.Arg691His Single submitter ⚠
- p.Asn167Lys Single submitter ⚠
- p.Asn174Ile Single submitter ⚠
- p.Asn541Ser Single submitter ⚠
- p.Asn544Lys Single submitter ⚠
- p.Asn623Lys Single submitter ⚠
- p.Asn632Ile Single submitter ⚠
- p.Asn640His Single submitter ⚠
- p.Asp183His Single submitter ⚠
- p.Asp197Tyr Single submitter ⚠
- p.Asp346Glu Single submitter ⚠
- p.Asp417Asn Single submitter ⚠
- p.Asp430Glu Single submitter ⚠
- p.Asp483Val Single submitter ⚠
- p.Cys170Gly Single submitter ⚠
- p.Cys389Tyr Single submitter ⚠
- p.Cys428Tyr Single submitter ⚠
- p.Cys442Tyr Single submitter ⚠
- p.Cys492Tyr Single submitter ⚠
- p.Cys499Ser Single submitter ⚠
- p.Cys556Tyr Single submitter ⚠
- p.Cys695Tyr Single submitter ⚠
- p.Gln452Glu Single submitter ⚠
- p.Gln510His Single submitter ⚠
- p.Gln721His Single submitter ⚠
- p.Gln722Glu Single submitter ⚠
- p.Gln751Arg Single submitter ⚠
- p.Glu25Asp Single submitter ⚠
- p.Glu412Asp Single submitter ⚠
- p.Glu446Gly Single submitter ⚠
- p.Glu449Lys Single submitter ⚠
- p.Glu550Lys Single submitter ⚠
- p.Glu652Asp Single submitter ⚠
- p.Glu661Lys Single submitter ⚠
- p.Glu79Val Single submitter ⚠
- p.Gly293Arg Single submitter ⚠
- p.Gly307Arg Single submitter ⚠
- p.Gly4Arg Single submitter ⚠
- p.Gly533Arg Single submitter ⚠
- p.Gly537Val Single submitter ⚠
- p.Gly571Ala Single submitter ⚠
- p.Gly607Arg Single submitter ⚠
- p.Gly613Arg Single submitter ⚠
- p.Gly684Arg Single submitter ⚠
- p.Gly715Val Single submitter ⚠
- p.His115Asp Single submitter ⚠
- p.His596Asn Single submitter ⚠
- p.Ile123Val Single submitter ⚠
- p.Ile195Thr Single submitter ⚠
- p.Ile242Asn Single submitter ⚠
- p.Ile258Met Single submitter ⚠
- p.Ile264Thr Single submitter ⚠
- p.Ile328Leu Single submitter ⚠
- p.Ile329Thr Single submitter ⚠
- p.Ile393Thr Single submitter ⚠
- p.Ile592Leu Single submitter ⚠
- p.Ile680Thr Single submitter ⚠
- p.Ile696Val Single submitter ⚠
- p.Ile6Thr Single submitter ⚠
- p.Ile728Asn Single submitter ⚠
- p.Ile728Met Single submitter ⚠
- p.Leu11Ser Single submitter ⚠
- p.Leu22Phe Single submitter ⚠
- p.Leu268Phe Single submitter ⚠
- p.Leu291Ile Single submitter ⚠
- p.Leu296Phe Single submitter ⚠
- p.Leu566Phe Single submitter ⚠
- p.Leu570Arg Single submitter ⚠
- p.Leu59Phe Single submitter ⚠
- p.Leu60Val Single submitter ⚠
- p.Leu676Phe Single submitter ⚠
- p.Leu729Gln Single submitter ⚠
- p.Lys191Glu Single submitter ⚠
- p.Lys455Arg Single submitter ⚠
- p.Lys590Arg Single submitter ⚠
- p.Lys714Ile Single submitter ⚠
- p.Lys93Asn Single submitter ⚠
- p.Met104Val Single submitter ⚠
- p.Met343Ile Single submitter ⚠
- p.Met501Thr Single submitter ⚠
- p.Met624Val Single submitter ⚠
- p.Phe132Leu Single submitter ⚠
- p.Phe133Leu Single submitter ⚠
- p.Phe370Leu Single submitter ⚠
- p.Phe500Leu Single submitter ⚠
- p.Pro101Thr Single submitter ⚠
- p.Pro163Leu Single submitter ⚠
- p.Pro366Ser Single submitter ⚠
- p.Pro581Thr Single submitter ⚠
- p.Pro738Leu Single submitter ⚠
- p.Ser112Cys Single submitter ⚠
- p.Ser262Ala Single submitter ⚠
- p.Ser512Phe Single submitter ⚠
- p.Ser522Asn Single submitter ⚠
- p.Thr425Ile Single submitter ⚠
- p.Thr441Ile Single submitter ⚠
- p.Thr46Ile Single submitter ⚠
- p.Thr46Pro Single submitter ⚠
- p.Thr591Ile Single submitter ⚠
- p.Tyr147His Single submitter ⚠
- p.Tyr385Cys Single submitter ⚠
- p.Tyr628His Single submitter ⚠
- p.Val247Ile Single submitter ⚠
- p.Val288Phe Single submitter ⚠
- p.Val289Ile Single submitter ⚠
- p.Val300Met Single submitter ⚠
- p.Val604Leu Single submitter ⚠
- p.Val627Ile Single submitter ⚠
- p.Val675Ala Single submitter ⚠
- p.Val71Ala Single submitter ⚠