ADAM8 — 198 ClinVar variants
All ClinVar germline ADAM8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 151 flagged for review →
2 Conflicting · 4 Benign · 46 Likely benign · 146 Uncertain significance
Full ADAM8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 151
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 2
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 69
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM8 p.Ala164Ser Uncertain significance Single submitter
- ADAM8 p.Ala397Thr Uncertain significance Single submitter
- ADAM8 p.Ala399Thr Uncertain significance Single submitter
- ADAM8 p.Ala573Val Uncertain significance Single submitter
- ADAM8 p.Ala633Thr Uncertain significance Single submitter
- ADAM8 p.Ala633Val Uncertain significance Single submitter
- ADAM8 p.Ala716Val Uncertain significance Single submitter
- ADAM8 p.Ala780Pro Uncertain significance Single submitter
- ADAM8 p.Ala792Val Uncertain significance Single submitter
- ADAM8 p.Ala818Pro Uncertain significance Single submitter
- ADAM8 p.Ala820Thr Uncertain significance Single submitter
- ADAM8 p.Ala820Val Uncertain significance Single submitter
- ADAM8 p.Arg100His Uncertain significance Single submitter
- ADAM8 p.Arg181Gln Uncertain significance Single submitter
- ADAM8 p.Arg279Gln Uncertain significance Single submitter
- ADAM8 p.Arg361His Uncertain significance Single submitter
- ADAM8 p.Arg418Pro Uncertain significance Single submitter
- ADAM8 p.Arg467Cys Uncertain significance Single submitter
- ADAM8 p.Arg590Gln Uncertain significance Single submitter
- ADAM8 p.Arg601His Uncertain significance Single submitter
- ADAM8 p.Arg682Gln Uncertain significance Single submitter
- ADAM8 p.Arg698Cys Uncertain significance Single submitter
- ADAM8 p.Arg698His Uncertain significance Single submitter
- ADAM8 p.Arg73Gln Uncertain significance Single submitter
- ADAM8 p.Arg814Lys Uncertain significance Single submitter
- ADAM8 p.Asn241His Uncertain significance Single submitter
- ADAM8 p.Asn270Ser Uncertain significance Single submitter
- ADAM8 p.Asp172Asn Uncertain significance Single submitter
- ADAM8 p.Cys124Ser Uncertain significance Single submitter
- ADAM8 p.Cys330Arg Uncertain significance Single submitter
- ADAM8 p.Cys411Tyr Uncertain significance Single submitter
- ADAM8 p.Cys457Tyr Uncertain significance Single submitter
- ADAM8 p.Cys479Trp Uncertain significance Single submitter
- ADAM8 p.Cys549Tyr Uncertain significance Single submitter
- ADAM8 p.Glu358Lys Uncertain significance Single submitter
- ADAM8 p.Gly360Ser Uncertain significance Single submitter
- ADAM8 p.Gly520Arg Uncertain significance Single submitter
- ADAM8 p.Gly588Arg Uncertain significance Single submitter
- ADAM8 p.Gly789Arg Uncertain significance Single submitter
- ADAM8 p.Gly803Arg Uncertain significance Single submitter
- ADAM8 p.His259Arg Uncertain significance Single submitter
- ADAM8 p.His283Gln Uncertain significance Single submitter
- ADAM8 p.Ile368Thr Uncertain significance Single submitter
- ADAM8 p.Ile565Val Uncertain significance Single submitter
- ADAM8 p.Ile567Val Uncertain significance Single submitter
- ADAM8 p.Leu384Val Uncertain significance Single submitter
- ADAM8 p.Met332Val Uncertain significance Single submitter
- ADAM8 p.Met364Thr Uncertain significance Single submitter
- ADAM8 p.Met472Val Uncertain significance Single submitter
- ADAM8 p.Pro115Ala Uncertain significance Single submitter
- ADAM8 p.Pro180Ser Uncertain significance Single submitter
- ADAM8 p.Pro19Ser Uncertain significance Single submitter
- ADAM8 p.Pro264Arg Uncertain significance Single submitter
- ADAM8 p.Pro426Ser Uncertain significance Single submitter
- ADAM8 p.Pro692His Uncertain significance Single submitter
- ADAM8 p.Pro784Ala Uncertain significance Single submitter
- ADAM8 p.Pro821Ala Uncertain significance Single submitter
- ADAM8 p.Ser610Phe Uncertain significance Single submitter
- ADAM8 p.Thr730Ile Uncertain significance Single submitter
- ADAM8 p.Trp598Cys Uncertain significance Single submitter
- ADAM8 p.Trp635Gly Uncertain significance Single submitter
- ADAM8 p.Tyr582Cys Uncertain significance Single submitter
- ADAM8 p.Val233Gly Uncertain significance Single submitter
- ADAM8 p.Val551Ile Uncertain significance Single submitter
- ADAM8 p.Val607Ile Uncertain significance Single submitter
- ADAM8 p.Val656Ile Uncertain significance Single submitter
- ADAM8 p.Val670Ile Uncertain significance Single submitter
- ADAM8 p.Val690Met Uncertain significance Single submitter
- ADAM8 p.Val710Ala Uncertain significance Single submitter
Predictors split 80
The independent predictors disagree with each other — read with care.
- ADAM8 p.Arg36His Benign Multiple submitters
- ADAM8 p.Arg433Cys Benign Multiple submitters
- ADAM8 p.Ala119Ser Uncertain significance Single submitter
- ADAM8 p.Ala119Thr Uncertain significance Single submitter
- ADAM8 p.Ala308Val Uncertain significance Single submitter
- ADAM8 p.Ala449Val Uncertain significance Single submitter
- ADAM8 p.Ala581Val Uncertain significance Single submitter
- ADAM8 p.Ala641Val Uncertain significance Single submitter
- ADAM8 p.Ala650Val Uncertain significance Single submitter
- ADAM8 p.Arg151Trp Uncertain significance Single submitter
- ADAM8 p.Arg181Trp Uncertain significance Single submitter
- ADAM8 p.Arg197Leu Uncertain significance Single submitter
- ADAM8 p.Arg200His Uncertain significance Single submitter
- ADAM8 p.Arg243Cys Uncertain significance Single submitter
- ADAM8 p.Arg243His Uncertain significance Single submitter
- ADAM8 p.Arg281Trp Uncertain significance Single submitter
- ADAM8 p.Arg356His Uncertain significance Single submitter
- ADAM8 p.Arg36Cys Uncertain significance Single submitter
- ADAM8 p.Arg36Leu Uncertain significance Single submitter
- ADAM8 p.Arg374Gly Uncertain significance Single submitter
- ADAM8 p.Arg431Trp Uncertain significance Single submitter
- ADAM8 p.Arg43Cys Uncertain significance Single submitter
- ADAM8 p.Arg601Cys Uncertain significance Single submitter
- ADAM8 p.Arg679Cys Uncertain significance Single submitter
- ADAM8 p.Arg679His Uncertain significance Single submitter
- ADAM8 p.Arg679Pro Uncertain significance Single submitter
- ADAM8 p.Arg684Cys Uncertain significance Single submitter
- ADAM8 p.Arg684His Uncertain significance Single submitter
- ADAM8 p.Arg709Cys Uncertain significance Single submitter
- ADAM8 p.Asn436Ser Uncertain significance Single submitter
- ADAM8 p.Asp295Ala Uncertain significance Single submitter
- ADAM8 p.Asp378Val Uncertain significance Single submitter
- ADAM8 p.Asp401Gly Uncertain significance Single submitter
- ADAM8 p.Gln132His Uncertain significance Single submitter
- ADAM8 p.Gln514His Uncertain significance Single submitter
- ADAM8 p.Gln627Glu Uncertain significance Single submitter
- ADAM8 p.Glu112Asp Uncertain significance Single submitter
- ADAM8 p.Glu148Lys Uncertain significance Single submitter
- ADAM8 p.Glu212Lys Uncertain significance Single submitter
- ADAM8 p.Glu355Lys Uncertain significance Single submitter
- ADAM8 p.Glu527Lys Uncertain significance Single submitter
- ADAM8 p.Glu587Lys Uncertain significance Single submitter
- ADAM8 p.Gly10Arg Uncertain significance Single submitter
- ADAM8 p.Gly126Ser Uncertain significance Single submitter
- ADAM8 p.Gly134Glu Uncertain significance Single submitter
- ADAM8 p.Gly298Ala Uncertain significance Single submitter
- ADAM8 p.Gly298Arg Uncertain significance Single submitter
- ADAM8 p.Gly408Ser Uncertain significance Single submitter
- ADAM8 p.Gly451Ser Uncertain significance Single submitter
- ADAM8 p.Gly579Val Uncertain significance Single submitter
- ADAM8 p.Leu61Ile Uncertain significance Single submitter
- ADAM8 p.Lys805Asn Uncertain significance Single submitter
- ADAM8 p.Pro391Leu Uncertain significance Single submitter
- ADAM8 p.Pro40Leu Uncertain significance Single submitter
- ADAM8 p.Pro487Leu Uncertain significance Single submitter
- ADAM8 p.Pro637Leu Uncertain significance Single submitter
- ADAM8 p.Pro711Leu Uncertain significance Single submitter
- ADAM8 p.Pro735Ser Uncertain significance Single submitter
- ADAM8 p.Pro748Leu Uncertain significance Single submitter
- ADAM8 p.Pro753Ala Uncertain significance Single submitter
- ADAM8 p.Ser58Gly Uncertain significance Single submitter
- ADAM8 p.Ser708Ile Uncertain significance Single submitter
- ADAM8 p.Ser758Cys Uncertain significance Single submitter
- ADAM8 p.Thr182Met Uncertain significance Single submitter
- ADAM8 p.Thr69Ile Uncertain significance Single submitter
- ADAM8 p.Thr778Met Uncertain significance Single submitter
- ADAM8 p.Thr88Met Uncertain significance Single submitter
- ADAM8 p.Thr96Met Uncertain significance Single submitter
- ADAM8 p.Val154Met Uncertain significance Single submitter
- ADAM8 p.Val169Ile Uncertain significance Single submitter
- ADAM8 p.Val202Leu Uncertain significance Single submitter
- ADAM8 p.Val208Met Uncertain significance Single submitter
- ADAM8 p.Val226Met Uncertain significance Single submitter
- ADAM8 p.Val233Met Uncertain significance Single submitter
- ADAM8 p.Val288Ile Uncertain significance Single submitter
- ADAM8 p.Val585Met Uncertain significance Single submitter
- ADAM8 p.Val60Ile Uncertain significance Single submitter
- ADAM8 p.Val659Leu Likely benign Single submitter
- ADAM8 p.Val763Ile Uncertain significance Single submitter
- ADAM8 p.Val802Ile Uncertain significance Single submitter
All ADAM8 variants
Conflicting classifications of pathogenicity 2
- p.Ala780Thr Single submitter ⚠
- p.His625Tyr Single submitter ⚠
Benign 4
- p.Ala118= Multiple submitters
- p.Ala490Thr Multiple submitters
- p.Arg36His Multiple submitters ⚠
- p.Arg433Cys Multiple submitters ⚠
Likely benign 46
- p.Ala125= Single submitter
- p.Ala18Val Single submitter
- p.Ala359= Single submitter
- p.Ala507Thr Single submitter
- p.Ala546Val Single submitter
- p.Ala63= Single submitter
- p.Ala740= Single submitter
- p.Ala798Thr Single submitter
- p.Arg100= Single submitter
- p.Arg151Gln Single submitter
- p.Arg189Gln Single submitter
- p.Arg281Gln Single submitter
- p.Arg390Gln Single submitter
- p.Arg433His Single submitter
- p.Arg482Gln Single submitter
- p.Arg543Trp Single submitter
- p.Arg709= Single submitter
- p.Arg768Gln Single submitter
- p.Asn324= Single submitter
- p.Gln275Arg Single submitter
- p.Glu27= Single submitter
- p.Glu55= Single submitter
- p.Gly101= Single submitter
- p.Gly652Arg Single submitter
- p.Gly800Ser Single submitter
- p.His110= Single submitter
- p.Leu70= Single submitter
- p.Leu72= Single submitter
- p.Lys642Glu Single submitter
- p.Pro711= Single submitter
- p.Pro719= Single submitter
- p.Pro732= Single submitter
- p.Pro735= Single submitter
- p.Pro748= Single submitter
- p.Pro753= Single submitter
- p.Pro782= Single submitter
- p.Pro788= Single submitter
- p.Ser371Thr Single submitter
- p.Ser742= Single submitter
- p.Ser758Arg Single submitter
- p.Ser93= Single submitter
- p.Thr452Ala Single submitter
- p.Thr496= Single submitter
- p.Val659Leu Single submitter ⚠
- p.Val677Ile Single submitter
- p.Val754= Single submitter
Uncertain significance 146
- p.Ala119Ser Single submitter ⚠
- p.Ala119Thr Single submitter ⚠
- p.Ala164Ser Single submitter ⚠
- p.Ala308Val Single submitter ⚠
- p.Ala397Thr Single submitter ⚠
- p.Ala399Thr Single submitter ⚠
- p.Ala449Val Single submitter ⚠
- p.Ala573Val Single submitter ⚠
- p.Ala581Val Single submitter ⚠
- p.Ala633Thr Single submitter ⚠
- p.Ala633Val Single submitter ⚠
- p.Ala641Val Single submitter ⚠
- p.Ala650Val Single submitter ⚠
- p.Ala716Val Single submitter ⚠
- p.Ala780Pro Single submitter ⚠
- p.Ala792Val Single submitter ⚠
- p.Ala818Pro Single submitter ⚠
- p.Ala820Thr Single submitter ⚠
- p.Ala820Val Single submitter ⚠
- p.Arg100His Single submitter ⚠
- p.Arg151Trp Single submitter ⚠
- p.Arg181Gln Single submitter ⚠
- p.Arg181Trp Single submitter ⚠
- p.Arg197Leu Single submitter ⚠
- p.Arg200His Single submitter ⚠
- p.Arg243Cys Single submitter ⚠
- p.Arg243His Single submitter ⚠
- p.Arg279Gln Single submitter ⚠
- p.Arg281Trp Single submitter ⚠
- p.Arg356His Single submitter ⚠
- p.Arg361His Single submitter ⚠
- p.Arg36Cys Single submitter ⚠
- p.Arg36Leu Single submitter ⚠
- p.Arg374Gly Single submitter ⚠
- p.Arg418Pro Single submitter ⚠
- p.Arg431Trp Single submitter ⚠
- p.Arg43Cys Single submitter ⚠
- p.Arg467Cys Single submitter ⚠
- p.Arg590Gln Single submitter ⚠
- p.Arg601Cys Single submitter ⚠
- p.Arg601His Single submitter ⚠
- p.Arg679Cys Single submitter ⚠
- p.Arg679His Single submitter ⚠
- p.Arg679Pro Single submitter ⚠
- p.Arg682Gln Single submitter ⚠
- p.Arg684Cys Single submitter ⚠
- p.Arg684His Single submitter ⚠
- p.Arg698Cys Single submitter ⚠
- p.Arg698His Single submitter ⚠
- p.Arg709Cys Single submitter ⚠
- p.Arg73Gln Single submitter ⚠
- p.Arg814Lys Single submitter ⚠
- p.Asn241His Single submitter ⚠
- p.Asn270Ser Single submitter ⚠
- p.Asn436Ser Single submitter ⚠
- p.Asp172Asn Single submitter ⚠
- p.Asp295Ala Single submitter ⚠
- p.Asp378Val Single submitter ⚠
- p.Asp401Gly Single submitter ⚠
- p.Cys124Ser Single submitter ⚠
- p.Cys330Arg Single submitter ⚠
- p.Cys411Tyr Single submitter ⚠
- p.Cys457Tyr Single submitter ⚠
- p.Cys479Trp Single submitter ⚠
- p.Cys549Tyr Single submitter ⚠
- p.Gln132His Single submitter ⚠
- p.Gln514His Single submitter ⚠
- p.Gln627Glu Single submitter ⚠
- p.Glu112Asp Single submitter ⚠
- p.Glu148Lys Single submitter ⚠
- p.Glu212Lys Single submitter ⚠
- p.Glu355Lys Single submitter ⚠
- p.Glu358Lys Single submitter ⚠
- p.Glu527Lys Single submitter ⚠
- p.Glu587Lys Single submitter ⚠
- p.Gly10Arg Single submitter ⚠
- p.Gly126Ser Single submitter ⚠
- p.Gly134Glu Single submitter ⚠
- p.Gly298Ala Single submitter ⚠
- p.Gly298Arg Single submitter ⚠
- p.Gly360Ser Single submitter ⚠
- p.Gly408Ser Single submitter ⚠
- p.Gly451Ser Single submitter ⚠
- p.Gly520Arg Single submitter ⚠
- p.Gly579Val Single submitter ⚠
- p.Gly588Arg Single submitter ⚠
- p.Gly789Arg Single submitter ⚠
- p.Gly803Arg Single submitter ⚠
- p.His259Arg Single submitter ⚠
- p.His283Gln Single submitter ⚠
- p.Ile368Thr Single submitter ⚠
- p.Ile565Val Single submitter ⚠
- p.Ile567Val Single submitter ⚠
- p.Leu384Val Single submitter ⚠
- p.Leu61Ile Single submitter ⚠
- p.Lys805Asn Single submitter ⚠
- p.Met332Val Single submitter ⚠
- p.Met364Thr Single submitter ⚠
- p.Met472Val Single submitter ⚠
- p.Pro115Ala Single submitter ⚠
- p.Pro180Ser Single submitter ⚠
- p.Pro19Ser Single submitter ⚠
- p.Pro264Arg Single submitter ⚠
- p.Pro391Leu Single submitter ⚠
- p.Pro40Leu Single submitter ⚠
- p.Pro426Ser Single submitter ⚠
- p.Pro487Leu Single submitter ⚠
- p.Pro637Leu Single submitter ⚠
- p.Pro692His Single submitter ⚠
- p.Pro711Leu Single submitter ⚠
- p.Pro735Ser Single submitter ⚠
- p.Pro748Leu Single submitter ⚠
- p.Pro753Ala Single submitter ⚠
- p.Pro784Ala Single submitter ⚠
- p.Pro821Ala Single submitter ⚠
- p.Ser58Gly Single submitter ⚠
- p.Ser610Phe Single submitter ⚠
- p.Ser708Ile Single submitter ⚠
- p.Ser758Cys Single submitter ⚠
- p.Thr182Met Single submitter ⚠
- p.Thr69Ile Single submitter ⚠
- p.Thr730Ile Single submitter ⚠
- p.Thr778Met Single submitter ⚠
- p.Thr88Met Single submitter ⚠
- p.Thr96Met Single submitter ⚠
- p.Trp598Cys Single submitter ⚠
- p.Trp635Gly Single submitter ⚠
- p.Tyr582Cys Single submitter ⚠
- p.Val154Met Single submitter ⚠
- p.Val169Ile Single submitter ⚠
- p.Val202Leu Single submitter ⚠
- p.Val208Met Single submitter ⚠
- p.Val226Met Single submitter ⚠
- p.Val233Gly Single submitter ⚠
- p.Val233Met Single submitter ⚠
- p.Val288Ile Single submitter ⚠
- p.Val551Ile Single submitter ⚠
- p.Val585Met Single submitter ⚠
- p.Val607Ile Single submitter ⚠
- p.Val60Ile Single submitter ⚠
- p.Val656Ile Single submitter ⚠
- p.Val670Ile Single submitter ⚠
- p.Val690Met Single submitter ⚠
- p.Val710Ala Single submitter ⚠
- p.Val763Ile Single submitter ⚠
- p.Val802Ile Single submitter ⚠