ADAMDEC1 — 77 ClinVar variants
All ClinVar germline ADAMDEC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
9 Benign · 4 Likely benign · 64 Uncertain significance
Full ADAMDEC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAMDEC1 p.Ala12Thr Uncertain significance Single submitter
- ADAMDEC1 p.Arg398Ser Uncertain significance Single submitter
- ADAMDEC1 p.Asn120Ser Uncertain significance Single submitter
- ADAMDEC1 p.Asn416Thr Uncertain significance Single submitter
- ADAMDEC1 p.Asn425Ile Uncertain significance Single submitter
- ADAMDEC1 p.Asp144Asn Uncertain significance Single submitter
- ADAMDEC1 p.Asp181Tyr Uncertain significance Single submitter
- ADAMDEC1 p.Asp275Asn Uncertain significance Single submitter
- ADAMDEC1 p.Cys124Arg Uncertain significance Single submitter
- ADAMDEC1 p.Cys369Tyr Uncertain significance Single submitter
- ADAMDEC1 p.Gln92Glu Uncertain significance Single submitter
- ADAMDEC1 p.Gly145Arg Uncertain significance Single submitter
- ADAMDEC1 p.Gly461Arg Uncertain significance Single submitter
- ADAMDEC1 p.Gly462Arg Uncertain significance Single submitter
- ADAMDEC1 p.Gly4Glu Uncertain significance Single submitter
- ADAMDEC1 p.Gly67Ser Uncertain significance Single submitter
- ADAMDEC1 p.His185Arg Uncertain significance Single submitter
- ADAMDEC1 p.His294Arg Uncertain significance Single submitter
- ADAMDEC1 p.His294Gln Uncertain significance Single submitter
- ADAMDEC1 p.His305Asp Uncertain significance Single submitter
- ADAMDEC1 p.His426Arg Uncertain significance Single submitter
- ADAMDEC1 p.His96Asn Uncertain significance Single submitter
- ADAMDEC1 p.Ile44Thr Uncertain significance Single submitter
- ADAMDEC1 p.Leu106Ser Uncertain significance Single submitter
- ADAMDEC1 p.Leu321Pro Uncertain significance Single submitter
- ADAMDEC1 p.Lys163Glu Uncertain significance Single submitter
- ADAMDEC1 p.Lys278Arg Uncertain significance Single submitter
- ADAMDEC1 p.Lys386Glu Uncertain significance Single submitter
- ADAMDEC1 p.Met14Leu Uncertain significance Single submitter
- ADAMDEC1 p.Met249Thr Uncertain significance Single submitter
- ADAMDEC1 p.Pro281Ser Uncertain significance Single submitter
- ADAMDEC1 p.Ser332Pro Uncertain significance Single submitter
- ADAMDEC1 p.Ser351Ala Uncertain significance Single submitter
- ADAMDEC1 p.Thr192Ile Uncertain significance Single submitter
- ADAMDEC1 p.Tyr126Cys Uncertain significance Single submitter
- ADAMDEC1 p.Tyr256His Uncertain significance Single submitter
- ADAMDEC1 p.Val11Ala Uncertain significance Single submitter
- ADAMDEC1 p.Val11Gly Uncertain significance Single submitter
- ADAMDEC1 p.Val280Ala Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- ADAMDEC1 p.Ile44Arg Benign Multiple submitters
- ADAMDEC1 p.Pro439Ser Benign Multiple submitters
- ADAMDEC1 p.Ala171Asp Uncertain significance Single submitter
- ADAMDEC1 p.Ala283Thr Likely benign Single submitter
- ADAMDEC1 p.Arg200Gln Uncertain significance Single submitter
- ADAMDEC1 p.Arg215Trp Uncertain significance Single submitter
- ADAMDEC1 p.Arg393His Uncertain significance Single submitter
- ADAMDEC1 p.Asn253Ser Uncertain significance Single submitter
- ADAMDEC1 p.Asn289Ser Uncertain significance Single submitter
- ADAMDEC1 p.Asn366Ile Uncertain significance Single submitter
- ADAMDEC1 p.Asp101Ala Uncertain significance Single submitter
- ADAMDEC1 p.Asp304Gly Uncertain significance Single submitter
- ADAMDEC1 p.Glu169Lys Uncertain significance Single submitter
- ADAMDEC1 p.Ile241Lys Uncertain significance Single submitter
- ADAMDEC1 p.Ile88Leu Uncertain significance Single submitter
- ADAMDEC1 p.Phe150Val Uncertain significance Single submitter
- ADAMDEC1 p.Pro412Thr Uncertain significance Single submitter
- ADAMDEC1 p.Ser141Gly Uncertain significance Single submitter
- ADAMDEC1 p.Ser331Phe Uncertain significance Single submitter
- ADAMDEC1 p.Ser90Cys Uncertain significance Single submitter
- ADAMDEC1 p.Thr186Ala Uncertain significance Single submitter
- ADAMDEC1 p.Thr390Ile Uncertain significance Single submitter
- ADAMDEC1 p.Thr458Asn Uncertain significance Single submitter
- ADAMDEC1 p.Thr63Ile Uncertain significance Single submitter
- ADAMDEC1 p.Tyr223Ser Uncertain significance Single submitter
- ADAMDEC1 p.Val172Phe Uncertain significance Single submitter
- ADAMDEC1 p.Val21Ala Uncertain significance Single submitter
- ADAMDEC1 p.Val245Met Uncertain significance Single submitter
All ADAMDEC1 variants
Benign 9
- c.762+10T>C Multiple submitters
- p.Glu441= Multiple submitters
- p.Ile255= Multiple submitters
- p.Ile44Arg Multiple submitters ⚠
- p.Ile81Thr Multiple submitters
- p.Met121Thr Multiple submitters
- p.Pro439Ser Multiple submitters ⚠
- p.Ser296= Multiple submitters
- p.Thr40Met Multiple submitters
Likely benign 4
- p.Ala283Thr Single submitter ⚠
- p.Arg3Cys Single submitter
- p.Cys460= Single submitter
- p.Gly194Arg Single submitter
Uncertain significance 64
- p.Ala12Thr Single submitter ⚠
- p.Ala171Asp Single submitter ⚠
- p.Arg200Gln Single submitter ⚠
- p.Arg215Trp Single submitter ⚠
- p.Arg393His Single submitter ⚠
- p.Arg398Ser Single submitter ⚠
- p.Asn120Ser Single submitter ⚠
- p.Asn253Ser Single submitter ⚠
- p.Asn289Ser Single submitter ⚠
- p.Asn366Ile Single submitter ⚠
- p.Asn416Thr Single submitter ⚠
- p.Asn425Ile Single submitter ⚠
- p.Asp101Ala Single submitter ⚠
- p.Asp144Asn Single submitter ⚠
- p.Asp181Tyr Single submitter ⚠
- p.Asp275Asn Single submitter ⚠
- p.Asp304Gly Single submitter ⚠
- p.Cys124Arg Single submitter ⚠
- p.Cys369Tyr Single submitter ⚠
- p.Gln92Glu Single submitter ⚠
- p.Glu169Lys Single submitter ⚠
- p.Gly145Arg Single submitter ⚠
- p.Gly461Arg Single submitter ⚠
- p.Gly462Arg Single submitter ⚠
- p.Gly4Glu Single submitter ⚠
- p.Gly67Ser Single submitter ⚠
- p.His185Arg Single submitter ⚠
- p.His294Arg Single submitter ⚠
- p.His294Gln Single submitter ⚠
- p.His305Asp Single submitter ⚠
- p.His426Arg Single submitter ⚠
- p.His96Asn Single submitter ⚠
- p.Ile241Lys Single submitter ⚠
- p.Ile44Thr Single submitter ⚠
- p.Ile88Leu Single submitter ⚠
- p.Leu106Ser Single submitter ⚠
- p.Leu321Pro Single submitter ⚠
- p.Lys163Glu Single submitter ⚠
- p.Lys278Arg Single submitter ⚠
- p.Lys386Glu Single submitter ⚠
- p.Met14Leu Single submitter ⚠
- p.Met249Thr Single submitter ⚠
- p.Phe150Val Single submitter ⚠
- p.Pro281Ser Single submitter ⚠
- p.Pro412Thr Single submitter ⚠
- p.Ser141Gly Single submitter ⚠
- p.Ser331Phe Single submitter ⚠
- p.Ser332Pro Single submitter ⚠
- p.Ser351Ala Single submitter ⚠
- p.Ser90Cys Single submitter ⚠
- p.Thr186Ala Single submitter ⚠
- p.Thr192Ile Single submitter ⚠
- p.Thr390Ile Single submitter ⚠
- p.Thr458Asn Single submitter ⚠
- p.Thr63Ile Single submitter ⚠
- p.Tyr126Cys Single submitter ⚠
- p.Tyr223Ser Single submitter ⚠
- p.Tyr256His Single submitter ⚠
- p.Val11Ala Single submitter ⚠
- p.Val11Gly Single submitter ⚠
- p.Val172Phe Single submitter ⚠
- p.Val21Ala Single submitter ⚠
- p.Val245Met Single submitter ⚠
- p.Val280Ala Single submitter ⚠