ADAMTS15 — 174 ClinVar variants

All ClinVar germline ADAMTS15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 156 flagged for review →

3 Pathogenic · 2 Likely pathogenic · 4 Benign · 1 Benign/Likely benign · 9 Likely benign · 155 Uncertain significance

Full ADAMTS15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 156

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 86

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 70

The independent predictors disagree with each other — read with care.

All ADAMTS15 variants

Pathogenic 3

c.1903-2A>G No assertion criteria arthrogryposis, distal, type 12
p.Gly761Ser No assertion criteria arthrogryposis, distal, type 12
p.Tyr41Ter No assertion criteria arthrogryposis, distal, type 12

Likely pathogenic 2

c.1903-2A>C Single submitter arthrogryposis, distal, type 12
p.Cys905Trp Single submitter arthrogryposis, distal, type 12

Benign 4

p.Gly235Ser Multiple submitters ⚠
p.Ile720= Multiple submitters
p.Leu947= Multiple submitters
p.Pro835= Multiple submitters

Benign/Likely benign 1

p.Ser760= Multiple submitters

Likely benign 9

p.Ala503Thr Single submitter
p.Ala901= Single submitter
p.His234= Single submitter
p.Lys606= Single submitter
p.Pro815Ser Single submitter
p.Ser857Gly Single submitter
p.Thr471= Single submitter
p.Val162= Single submitter
p.Val536Met Single submitter

Uncertain significance 155

p.Ala183Thr Single submitter ⚠
p.Ala196Gly Single submitter ⚠
p.Ala360Thr Single submitter ⚠
p.Ala405Thr Single submitter ⚠
p.Ala451Thr Single submitter ⚠
p.Ala520Gly Single submitter ⚠
p.Ala520Thr Single submitter ⚠
p.Ala586Thr Single submitter ⚠
p.Ala657Gly Single submitter ⚠
p.Ala701Thr Single submitter ⚠
p.Ala704Val Single submitter ⚠
p.Ala78Thr Single submitter ⚠
p.Ala877Val Single submitter ⚠
p.Ala889Thr Single submitter ⚠
p.Ala889Val Single submitter ⚠
p.Ala901Thr Single submitter ⚠
p.Arg218Gln Single submitter ⚠
p.Arg275Cys Single submitter ⚠
p.Arg483His Single submitter ⚠
p.Arg507Lys Single submitter ⚠
p.Arg530Cys Single submitter ⚠
p.Arg530His Single submitter ⚠
p.Arg596Trp Single submitter ⚠
p.Arg613Gln Single submitter ⚠
p.Arg613Trp Single submitter ⚠
p.Arg758Trp Single submitter ⚠
p.Arg773Trp Single submitter ⚠
p.Arg793Gln Single submitter ⚠
p.Arg816Gly Single submitter ⚠
p.Arg867Trp Single submitter ⚠
p.Arg873His Single submitter ⚠
p.Arg883Trp Single submitter ⚠
p.Arg916His Single submitter ⚠
p.Arg926Gln Single submitter ⚠
p.Arg926Trp Single submitter ⚠
p.Arg930Trp Single submitter ⚠
p.Asn141Ser Single submitter ⚠
p.Asn284His Single submitter ⚠
p.Asn545Thr Single submitter ⚠
p.Asn662His Single submitter ⚠
p.Asp106Asn Single submitter ⚠
p.Asp112His Single submitter ⚠
p.Asp320Asn Single submitter ⚠
p.Asp32Ala Single submitter ⚠
p.Asp398Tyr Single submitter ⚠
p.Asp413Gly Single submitter ⚠
p.Asp489Asn Single submitter ⚠
p.Asp516Gly Single submitter ⚠
p.Asp644Glu Single submitter ⚠
p.Asp644Gly Single submitter ⚠
p.Asp678Asn Single submitter ⚠
p.Asp807Asn Single submitter ⚠
p.Asp814Asn Single submitter ⚠
p.Asp814Glu Single submitter ⚠
p.Asp814Gly Single submitter ⚠
p.Asp837Asn Single submitter ⚠
p.Cys465Tyr Single submitter ⚠
p.Cys945Gly Single submitter ⚠
p.Gln770Arg Single submitter ⚠
p.Glu110Lys Single submitter ⚠
p.Glu308Lys Single submitter ⚠
p.Glu349Ala Single submitter ⚠
p.Glu46Lys Single submitter ⚠
p.Glu556Gly Single submitter ⚠
p.Glu581Gly Single submitter ⚠
p.Glu582Gly Single submitter ⚠
p.Glu582Lys Single submitter ⚠
p.Glu62Lys Single submitter ⚠
p.Glu777Asp Single submitter ⚠
p.Glu82Gln Single submitter ⚠
p.Glu833Gln Single submitter ⚠
p.Gly165Arg Single submitter ⚠
p.Gly168Arg Single submitter ⚠
p.Gly179Arg Single submitter ⚠
p.Gly208Ala Single submitter ⚠
p.Gly455Cys Single submitter ⚠
p.Gly49Glu Single submitter ⚠
p.Gly526Ser Single submitter ⚠
p.Gly534Glu Single submitter ⚠
p.Gly551Arg Single submitter ⚠
p.Gly589Ser Single submitter ⚠
p.Gly609Ser Single submitter ⚠
p.Gly638Ser Single submitter ⚠
p.Gly664Val Single submitter ⚠
p.Gly673Ala Single submitter ⚠
p.Gly676Trp Single submitter ⚠
p.Gly891Arg Single submitter ⚠
p.Gly910Ser Single submitter ⚠
p.Gly922Ser Single submitter ⚠
p.Gly924Arg Single submitter ⚠
p.His67Arg Single submitter ⚠
p.His67Gln Single submitter ⚠
p.Ile216Asn Single submitter ⚠
p.Ile655Leu Single submitter ⚠
p.Ile655Val Single submitter ⚠
p.Leu157Pro Single submitter ⚠
p.Leu259Phe Single submitter ⚠
p.Leu394Val Single submitter ⚠
p.Leu433Arg Single submitter ⚠
p.Leu437Met Single submitter ⚠
p.Leu84Gln Single submitter ⚠
p.Leu84Val Single submitter ⚠
p.Leu88Phe Single submitter ⚠
p.Leu899Val Single submitter ⚠
p.Lys192Gln Single submitter ⚠
p.Lys521Glu Single submitter ⚠
p.Lys680Glu Single submitter ⚠
p.Met369Val Single submitter ⚠
p.Met389Val Single submitter ⚠
p.Phe60Leu Single submitter ⚠
p.Pro138Arg Single submitter ⚠
p.Pro145Leu Single submitter ⚠
p.Pro217Arg Single submitter ⚠
p.Pro307Leu Single submitter ⚠
p.Pro392Leu Single submitter ⚠
p.Pro569Thr Single submitter ⚠
p.Pro692Arg Single submitter ⚠
p.Pro778Thr Single submitter ⚠
p.Pro791Leu Single submitter ⚠
p.Pro835Leu Single submitter ⚠
p.Pro850Arg Single submitter ⚠
p.Pro904Leu Single submitter ⚠
p.Pro949Leu Single submitter ⚠
p.Ser178Leu Single submitter ⚠
p.Ser257Gly Single submitter ⚠
p.Ser428Asn Single submitter ⚠
p.Ser48Tyr Single submitter ⚠
p.Ser492Gly Single submitter ⚠
p.Ser575Tyr Single submitter ⚠
p.Ser645Phe Single submitter ⚠
p.Ser744Leu Single submitter ⚠
p.Ser857Asn Single submitter ⚠
p.Thr359Ile Single submitter ⚠
p.Thr471Ile Single submitter ⚠
p.Thr482Ile Single submitter ⚠
p.Thr646Ile Single submitter ⚠
p.Thr762Met Single submitter ⚠
p.Trp522Cys Single submitter ⚠
p.Tyr129Cys Single submitter ⚠
p.Tyr191Asn Single submitter ⚠
p.Tyr253His Single submitter ⚠
p.Tyr253Phe Single submitter ⚠
p.Tyr590Cys Single submitter ⚠
p.Tyr627Cys Single submitter ⚠
p.Tyr796His Single submitter ⚠
p.Tyr799Cys Single submitter ⚠
p.Val374Met Single submitter ⚠
p.Val454Leu Single submitter ⚠
p.Val505Met Single submitter ⚠
p.Val601Met Single submitter ⚠
p.Val648Ala Single submitter ⚠
p.Val648Ile Single submitter ⚠
p.Val781Met Single submitter ⚠
p.Val832Met Single submitter ⚠
p.Val885Leu Single submitter ⚠