Sugi Variant

Sugi Variant/ADAMTS18

ADAMTS18 — 1232 ClinVar variants

All ClinVar germline ADAMTS18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 620 flagged for review →

44 Pathogenic · 3 Pathogenic/Likely pathogenic · 12 Likely pathogenic · 18 Conflicting · 54 Benign · 5 Benign/Likely benign · 477 Likely benign · 619 Uncertain significance

Full ADAMTS18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 620

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 13

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 332

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 332

Predictors split 275

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 275

All ADAMTS18 variants

Pathogenic 44

Pathogenic/Likely pathogenic 3

Likely pathogenic 12

Conflicting classifications of pathogenicity 18

Benign 54

Benign/Likely benign 5

Likely benign 477

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 619

Showing the top 300 by review status; the full set is in the sitemap.