ADAMTS4 — 134 ClinVar variants

All ClinVar germline ADAMTS4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 127 flagged for review →

1 Benign · 7 Likely benign · 126 Uncertain significance

Full ADAMTS4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 127

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 59

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 68

The independent predictors disagree with each other — read with care.

All ADAMTS4 variants

Benign 1

c.*56A>G Multiple submitters

Likely benign 7

p.Arg15Cys Single submitter
p.Arg696= Single submitter
p.Gly9Arg Single submitter
p.Ile665Val Single submitter
p.Ser100Pro Single submitter
p.Thr91Ala Single submitter
p.Val71Ile Single submitter ⚠

Uncertain significance 126

p.Ala115Val Single submitter ⚠
p.Ala20Ser Single submitter ⚠
p.Ala236Val Single submitter ⚠
p.Ala252Asp Single submitter ⚠
p.Ala286Val Single submitter ⚠
p.Ala313Gly Single submitter ⚠
p.Ala430Thr Single submitter ⚠
p.Ala498Thr Single submitter ⚠
p.Ala589Thr Single submitter ⚠
p.Ala834Gly Single submitter ⚠
p.Arg156Gln Single submitter ⚠
p.Arg182Cys Single submitter ⚠
p.Arg182His Single submitter ⚠
p.Arg183Gln Single submitter ⚠
p.Arg208Gln Single submitter ⚠
p.Arg209Gly Single submitter ⚠
p.Arg212Cys Single submitter ⚠
p.Arg212Ser Single submitter ⚠
p.Arg240Cys Single submitter ⚠
p.Arg290His Single submitter ⚠
p.Arg388His Single submitter ⚠
p.Arg410Cys Single submitter ⚠
p.Arg410Gly Single submitter ⚠
p.Arg447Leu Single submitter ⚠
p.Arg458Cys Single submitter ⚠
p.Arg534Gln Single submitter ⚠
p.Arg562Cys Single submitter ⚠
p.Arg562His Single submitter ⚠
p.Arg563His Single submitter ⚠
p.Arg567His Single submitter ⚠
p.Arg593Cys Single submitter ⚠
p.Arg609His Single submitter ⚠
p.Arg637Gln Single submitter ⚠
p.Arg664Cys Single submitter ⚠
p.Arg664His Single submitter ⚠
p.Arg723Gln Single submitter ⚠
p.Arg723Trp Single submitter ⚠
p.Arg760Cys Single submitter ⚠
p.Arg760His Single submitter ⚠
p.Arg820Gln Single submitter ⚠
p.Arg830Trp Single submitter ⚠
p.Arg831Cys Single submitter ⚠
p.Arg831His Single submitter ⚠
p.Arg831Leu Single submitter ⚠
p.Arg831Ser Single submitter ⚠
p.Arg84Cys Single submitter ⚠
p.Arg84His Single submitter ⚠
p.Asn418His Single submitter ⚠
p.Asn418Ser Single submitter ⚠
p.Asn516His Single submitter ⚠
p.Asn570Ser Single submitter ⚠
p.Asn719Ser Single submitter ⚠
p.Asp308His Single submitter ⚠
p.Asp456Asn Single submitter ⚠
p.Asp681Glu Single submitter ⚠
p.Gln717His Single submitter ⚠
p.Gln98Arg Single submitter ⚠
p.Glu105Val Single submitter ⚠
p.Glu584Lys Single submitter ⚠
p.Glu58Gly Single submitter ⚠
p.Glu826Asp Single submitter ⚠
p.Glu95Lys Single submitter ⚠
p.Gly101Ser Single submitter ⚠
p.Gly106Arg Single submitter ⚠
p.Gly14Glu Single submitter ⚠
p.Gly237Glu Single submitter ⚠
p.Gly336Ser Single submitter ⚠
p.Gly454Arg Single submitter ⚠
p.Gly539Asp Single submitter ⚠
p.Gly679Arg Single submitter ⚠
p.Gly679Glu Single submitter ⚠
p.Gly69Ser Single submitter ⚠
p.Gly74Asp Single submitter ⚠
p.Gly763Val Single submitter ⚠
p.Gly76Asp Single submitter ⚠
p.His309Pro Single submitter ⚠
p.His397Tyr Single submitter ⚠
p.His7Arg Single submitter ⚠
p.His7Gln Single submitter ⚠
p.His819Arg Single submitter ⚠
p.Ile61Met Single submitter ⚠
p.Leu26Ile Single submitter ⚠
p.Leu507Phe Single submitter ⚠
p.Leu55Pro Single submitter ⚠
p.Leu580Pro Single submitter ⚠
p.Leu786Val Single submitter ⚠
p.Leu818Pro Single submitter ⚠
p.Lys184Arg Single submitter ⚠
p.Lys254Glu Single submitter ⚠
p.Lys598Arg Single submitter ⚠
p.Met502Val Single submitter ⚠
p.Met676Leu Single submitter ⚠
p.Phe692Leu Single submitter ⚠
p.Pro116Ser Single submitter ⚠
p.Pro176Arg Single submitter ⚠
p.Pro302Ser Single submitter ⚠
p.Pro341Leu Single submitter ⚠
p.Pro400Ala Single submitter ⚠
p.Pro406Leu Single submitter ⚠
p.Pro406Ser Single submitter ⚠
p.Pro435Ser Single submitter ⚠
p.Pro455Ser Single submitter ⚠
p.Pro461Leu Single submitter ⚠
p.Pro464Arg Single submitter ⚠
p.Pro805Gln Single submitter ⚠
p.Pro805Leu Single submitter ⚠
p.Pro814Ser Single submitter ⚠
p.Ser291Gly Single submitter ⚠
p.Ser379Asn Single submitter ⚠
p.Ser648Thr Single submitter ⚠
p.Ser758Gly Single submitter ⚠
p.Thr126Ala Single submitter ⚠
p.Thr548Met Single submitter ⚠
p.Thr564Ser Single submitter ⚠
p.Thr611Pro Single submitter ⚠
p.Thr782Lys Single submitter ⚠
p.Thr813Ile Single submitter ⚠
p.Thr91Met Single submitter ⚠
p.Val152Met Single submitter ⚠
p.Val224Ala Single submitter ⚠
p.Val35Met Single submitter ⚠
p.Val398Gly Single submitter ⚠
p.Val436Met Single submitter ⚠
p.Val62Met Single submitter ⚠
p.Val638Leu Single submitter ⚠
p.Val802Met Single submitter ⚠