ADAMTS5 — 147 ClinVar variants
All ClinVar germline ADAMTS5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 142 flagged for review →
7 Benign · 1 Likely benign · 139 Uncertain significance
Full ADAMTS5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 142
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 92
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAMTS5 p.Ala116Val Uncertain significance Single submitter
- ADAMTS5 p.Ala122Val Uncertain significance Single submitter
- ADAMTS5 p.Ala161Ser Uncertain significance Single submitter
- ADAMTS5 p.Ala213Ser Uncertain significance Single submitter
- ADAMTS5 p.Ala41Ser Uncertain significance Single submitter
- ADAMTS5 p.Ala493Asp Uncertain significance Single submitter
- ADAMTS5 p.Ala65Glu Uncertain significance Single submitter
- ADAMTS5 p.Ala65Val Uncertain significance Single submitter
- ADAMTS5 p.Ala886Ser Uncertain significance Single submitter
- ADAMTS5 p.Ala910Gly Uncertain significance Single submitter
- ADAMTS5 p.Arg104Gln Uncertain significance Single submitter
- ADAMTS5 p.Arg127Gly Uncertain significance Single submitter
- ADAMTS5 p.Arg162Ser Uncertain significance Single submitter
- ADAMTS5 p.Arg170Gly Uncertain significance Single submitter
- ADAMTS5 p.Arg267Ser Uncertain significance Single submitter
- ADAMTS5 p.Arg392Cys Uncertain significance Single submitter
- ADAMTS5 p.Arg392Ser Uncertain significance Single submitter
- ADAMTS5 p.Arg46Pro Uncertain significance Single submitter
- ADAMTS5 p.Arg54Leu Uncertain significance Single submitter
- ADAMTS5 p.Arg581Cys Uncertain significance Single submitter
- ADAMTS5 p.Arg592His Uncertain significance Single submitter
- ADAMTS5 p.Arg604His Uncertain significance Single submitter
- ADAMTS5 p.Arg610Lys Uncertain significance Single submitter
- ADAMTS5 p.Arg629Cys Uncertain significance Single submitter
- ADAMTS5 p.Arg761Gln Uncertain significance Single submitter
- ADAMTS5 p.Arg907Gln Uncertain significance Single submitter
- ADAMTS5 p.Asn227Ile Uncertain significance Single submitter
- ADAMTS5 p.Asn695Lys Uncertain significance Single submitter
- ADAMTS5 p.Asn802Ser Uncertain significance Single submitter
- ADAMTS5 p.Asp184Asn Uncertain significance Single submitter
- ADAMTS5 p.Asp767Asn Uncertain significance Single submitter
- ADAMTS5 p.Cys721Trp Uncertain significance Single submitter
- ADAMTS5 p.Gln268Arg Uncertain significance Single submitter
- ADAMTS5 p.Gln33Lys Uncertain significance Single submitter
- ADAMTS5 p.Gln47His Uncertain significance Single submitter
- ADAMTS5 p.Gln75Glu Uncertain significance Single submitter
- ADAMTS5 p.Gln876Lys Uncertain significance Single submitter
- ADAMTS5 p.Glu220Lys Uncertain significance Single submitter
- ADAMTS5 p.Glu368Lys Uncertain significance Single submitter
- ADAMTS5 p.Glu49Gly Uncertain significance Single submitter
- ADAMTS5 p.Gly138Arg Uncertain significance Single submitter
- ADAMTS5 p.Gly179Arg Uncertain significance Single submitter
- ADAMTS5 p.Gly21Asp Uncertain significance Single submitter
- ADAMTS5 p.Gly284Cys Uncertain significance Single submitter
- ADAMTS5 p.Gly32Arg Uncertain significance Single submitter
- ADAMTS5 p.Gly32Glu Uncertain significance Single submitter
- ADAMTS5 p.Gly48Arg Uncertain significance Single submitter
- ADAMTS5 p.Gly603Val Uncertain significance Single submitter
-
ADAMTS5 p.Gly726Arg
Uncertain significance
Single submitter
primary ovarian failure
- ADAMTS5 p.Gly782Val Uncertain significance Single submitter
- ADAMTS5 p.Gly810Ser Uncertain significance Single submitter
- ADAMTS5 p.Gly85Cys Uncertain significance Single submitter
- ADAMTS5 p.His414Arg Uncertain significance Single submitter
- ADAMTS5 p.His60Gln Uncertain significance Single submitter
- ADAMTS5 p.His62Arg Uncertain significance Single submitter
- ADAMTS5 p.His630Arg Uncertain significance Single submitter
- ADAMTS5 p.His896Tyr Uncertain significance Single submitter
- ADAMTS5 p.Ile387Val Uncertain significance Single submitter
- ADAMTS5 p.Lys544Arg Uncertain significance Single submitter
- ADAMTS5 p.Lys71Asn Uncertain significance Single submitter
- ADAMTS5 p.Lys780Glu Uncertain significance Single submitter
- ADAMTS5 p.Lys869Ile Uncertain significance Single submitter
- ADAMTS5 p.Lys911Arg Uncertain significance Single submitter
- ADAMTS5 p.Pro172Leu Uncertain significance Single submitter
- ADAMTS5 p.Pro204Ser Uncertain significance Single submitter
- ADAMTS5 p.Pro503Ser Uncertain significance Single submitter
- ADAMTS5 p.Pro61Arg Uncertain significance Single submitter
- ADAMTS5 p.Pro63Thr Uncertain significance Single submitter
- ADAMTS5 p.Pro752Ser Uncertain significance Single submitter
- ADAMTS5 p.Pro914Ser Uncertain significance Single submitter
- ADAMTS5 p.Ser327Gly Uncertain significance Single submitter
- ADAMTS5 p.Ser393Gly Uncertain significance Single submitter
- ADAMTS5 p.Ser453Phe Uncertain significance Single submitter
- ADAMTS5 p.Ser730Arg Uncertain significance Single submitter
- ADAMTS5 p.Ser824Tyr Uncertain significance Single submitter
- ADAMTS5 p.Ser848Ile Uncertain significance Single submitter
- ADAMTS5 p.Ser888Phe Uncertain significance Single submitter
- ADAMTS5 p.Thr293Ile Uncertain significance Single submitter
- ADAMTS5 p.Thr337Ile Uncertain significance Single submitter
- ADAMTS5 p.Thr540Met Uncertain significance Single submitter
- ADAMTS5 p.Thr685Pro Uncertain significance Single submitter
- ADAMTS5 p.Thr746Ala Uncertain significance Single submitter
- ADAMTS5 p.Trp255Arg Uncertain significance Single submitter
- ADAMTS5 p.Trp5Leu Uncertain significance Single submitter
- ADAMTS5 p.Val181Glu Uncertain significance Single submitter
- ADAMTS5 p.Val269Ala Uncertain significance Single submitter
- ADAMTS5 p.Val269Met Uncertain significance Single submitter
- ADAMTS5 p.Val384Phe Uncertain significance Single submitter
- ADAMTS5 p.Val699Ala Uncertain significance Single submitter
- ADAMTS5 p.Val699Ile Uncertain significance Single submitter
- ADAMTS5 p.Val735Ala Uncertain significance Single submitter
- ADAMTS5 p.Val900Met Uncertain significance Single submitter
Predictors split 50
The independent predictors disagree with each other — read with care.
- ADAMTS5 p.Arg614His Benign Multiple submitters
- ADAMTS5 p.Leu244Phe Benign Multiple submitters
- ADAMTS5 p.Ala298Ser Uncertain significance Single submitter
- ADAMTS5 p.Ala635Val Uncertain significance Single submitter
- ADAMTS5 p.Ala6Ser Uncertain significance Single submitter
- ADAMTS5 p.Arg195His Uncertain significance Single submitter
- ADAMTS5 p.Arg257Gln Uncertain significance Single submitter
- ADAMTS5 p.Arg267His Uncertain significance Single submitter
- ADAMTS5 p.Arg281Trp Uncertain significance Single submitter
- ADAMTS5 p.Arg46Trp Uncertain significance Single submitter
- ADAMTS5 p.Arg546Thr Uncertain significance Single submitter
- ADAMTS5 p.Arg907Trp Uncertain significance Single submitter
- ADAMTS5 p.Arg918Ser Uncertain significance Single submitter
- ADAMTS5 p.Asn906Thr Uncertain significance Single submitter
- ADAMTS5 p.Asp105Val Uncertain significance Single submitter
- ADAMTS5 p.Asp184Tyr Uncertain significance Single submitter
- ADAMTS5 p.Asp555His Uncertain significance Single submitter
- ADAMTS5 p.Asp642Glu Uncertain significance Single submitter
- ADAMTS5 p.Glu391Ala Uncertain significance Single submitter
- ADAMTS5 p.Glu484Gly Uncertain significance Single submitter
- ADAMTS5 p.Gly183Trp Uncertain significance Single submitter
- ADAMTS5 p.Gly284Ser Uncertain significance Single submitter
- ADAMTS5 p.Gly4Glu Uncertain significance Single submitter
- ADAMTS5 p.Gly525Ser Uncertain significance Single submitter
- ADAMTS5 p.Gly577Ser Benign Single submitter
- ADAMTS5 p.Gly638Asp Uncertain significance Single submitter
- ADAMTS5 p.Gly85Val Uncertain significance Single submitter
- ADAMTS5 p.Gly95Asp Uncertain significance Single submitter
- ADAMTS5 p.His567Gln Uncertain significance Single submitter
- ADAMTS5 p.Ile734Thr Uncertain significance Single submitter
- ADAMTS5 p.Ile799Thr Uncertain significance Single submitter
- ADAMTS5 p.Leu148Phe Uncertain significance Single submitter
- ADAMTS5 p.Leu273Val Uncertain significance Single submitter
- ADAMTS5 p.Leu9Met Uncertain significance Single submitter
- ADAMTS5 p.Lys559Thr Uncertain significance Single submitter
- ADAMTS5 p.Met527Ile Uncertain significance Single submitter
- ADAMTS5 p.Phe98Leu Uncertain significance Single submitter
- ADAMTS5 p.Pro541Ala Uncertain significance Single submitter
- ADAMTS5 p.Ser107Pro Uncertain significance Single submitter
- ADAMTS5 p.Ser186Cys Uncertain significance Single submitter
- ADAMTS5 p.Ser506Pro Uncertain significance Single submitter
- ADAMTS5 p.Ser506Tyr Uncertain significance Single submitter
- ADAMTS5 p.Ser575Tyr Uncertain significance Single submitter
- ADAMTS5 p.Ser694Asn Uncertain significance Single submitter
- ADAMTS5 p.Thr794Pro Uncertain significance Single submitter
- ADAMTS5 p.Thr797Ile Uncertain significance Single submitter
- ADAMTS5 p.Val384Ile Uncertain significance Single submitter
- ADAMTS5 p.Val507Met Uncertain significance Single submitter
- ADAMTS5 p.Val74Ala Uncertain significance Single submitter
- ADAMTS5 p.Val87Glu Uncertain significance Single submitter
All ADAMTS5 variants
Benign 7
- p.Arg614His Multiple submitters ⚠
- p.His310Tyr Multiple submitters
- p.Leu244Phe Multiple submitters ⚠
- p.Leu692= Multiple submitters
- p.Leu692Pro Multiple submitters
- p.Ala280= Single submitter
- p.Gly577Ser Single submitter ⚠
Likely benign 1
- p.Gly284= Multiple submitters
Uncertain significance 139
- p.Ala116Val Single submitter ⚠
- p.Ala122Val Single submitter ⚠
- p.Ala161Ser Single submitter ⚠
- p.Ala213Ser Single submitter ⚠
- p.Ala298Ser Single submitter ⚠
- p.Ala41Ser Single submitter ⚠
- p.Ala493Asp Single submitter ⚠
- p.Ala635Val Single submitter ⚠
- p.Ala65Glu Single submitter ⚠
- p.Ala65Val Single submitter ⚠
- p.Ala6Ser Single submitter ⚠
- p.Ala886Ser Single submitter ⚠
- p.Ala910Gly Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg127Gly Single submitter ⚠
- p.Arg162Ser Single submitter ⚠
- p.Arg170Gly Single submitter ⚠
- p.Arg195His Single submitter ⚠
- p.Arg257Gln Single submitter ⚠
- p.Arg267His Single submitter ⚠
- p.Arg267Ser Single submitter ⚠
- p.Arg281Trp Single submitter ⚠
- p.Arg392Cys Single submitter ⚠
- p.Arg392Ser Single submitter ⚠
- p.Arg46Pro Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Arg546Thr Single submitter ⚠
- p.Arg54Leu Single submitter ⚠
- p.Arg581Cys Single submitter ⚠
- p.Arg592His Single submitter ⚠
- p.Arg604His Single submitter ⚠
- p.Arg610Lys Single submitter ⚠
- p.Arg629Cys Single submitter ⚠
- p.Arg761Gln Single submitter ⚠
- p.Arg907Gln Single submitter ⚠
- p.Arg907Trp Single submitter ⚠
- p.Arg918Ser Single submitter ⚠
- p.Asn227Ile Single submitter ⚠
- p.Asn695Lys Single submitter ⚠
- p.Asn802Ser Single submitter ⚠
- p.Asn906Thr Single submitter ⚠
- p.Asp105Val Single submitter ⚠
- p.Asp184Asn Single submitter ⚠
- p.Asp184Tyr Single submitter ⚠
- p.Asp555His Single submitter ⚠
- p.Asp642Glu Single submitter ⚠
- p.Asp767Asn Single submitter ⚠
- p.Cys721Trp Single submitter ⚠
- p.Gln268Arg Single submitter ⚠
- p.Gln33Lys Single submitter ⚠
- p.Gln47His Single submitter ⚠
- p.Gln75Glu Single submitter ⚠
- p.Gln876Lys Single submitter ⚠
- p.Glu220Lys Single submitter ⚠
- p.Glu368Lys Single submitter ⚠
- p.Glu391Ala Single submitter ⚠
- p.Glu484Gly Single submitter ⚠
- p.Glu49Gly Single submitter ⚠
- p.Gly138Arg Single submitter ⚠
- p.Gly179Arg Single submitter ⚠
- p.Gly183Trp Single submitter ⚠
- p.Gly21Asp Single submitter ⚠
- p.Gly284Cys Single submitter ⚠
- p.Gly284Ser Single submitter ⚠
- p.Gly32Arg Single submitter ⚠
- p.Gly32Glu Single submitter ⚠
- p.Gly48Arg Single submitter ⚠
- p.Gly4Glu Single submitter ⚠
- p.Gly525Ser Single submitter ⚠
- p.Gly603Val Single submitter ⚠
- p.Gly638Asp Single submitter ⚠
- p.Gly726Arg Single submitter primary ovarian failure ⚠
- p.Gly782Val Single submitter ⚠
- p.Gly810Ser Single submitter ⚠
- p.Gly85Cys Single submitter ⚠
- p.Gly85Val Single submitter ⚠
- p.Gly95Asp Single submitter ⚠
- p.His414Arg Single submitter ⚠
- p.His567Gln Single submitter ⚠
- p.His60Gln Single submitter ⚠
- p.His62Arg Single submitter ⚠
- p.His630Arg Single submitter ⚠
- p.His896Tyr Single submitter ⚠
- p.Ile387Val Single submitter ⚠
- p.Ile734Thr Single submitter ⚠
- p.Ile799Thr Single submitter ⚠
- p.Leu148Phe Single submitter ⚠
- p.Leu273Val Single submitter ⚠
- p.Leu9Met Single submitter ⚠
- p.Lys544Arg Single submitter ⚠
- p.Lys559Thr Single submitter ⚠
- p.Lys71Asn Single submitter ⚠
- p.Lys780Glu Single submitter ⚠
- p.Lys869Ile Single submitter ⚠
- p.Lys911Arg Single submitter ⚠
- p.Met527Ile Single submitter ⚠
- p.Phe98Leu Single submitter ⚠
- p.Pro172Leu Single submitter ⚠
- p.Pro204Ser Single submitter ⚠
- p.Pro503Ser Single submitter ⚠
- p.Pro541Ala Single submitter ⚠
- p.Pro61Arg Single submitter ⚠
- p.Pro63Thr Single submitter ⚠
- p.Pro752Ser Single submitter ⚠
- p.Pro914Ser Single submitter ⚠
- p.Ser107Pro Single submitter ⚠
- p.Ser186Cys Single submitter ⚠
- p.Ser327Gly Single submitter ⚠
- p.Ser393Gly Single submitter ⚠
- p.Ser453Phe Single submitter ⚠
- p.Ser506Pro Single submitter ⚠
- p.Ser506Tyr Single submitter ⚠
- p.Ser575Tyr Single submitter ⚠
- p.Ser694Asn Single submitter ⚠
- p.Ser730Arg Single submitter ⚠
- p.Ser824Tyr Single submitter ⚠
- p.Ser848Ile Single submitter ⚠
- p.Ser888Phe Single submitter ⚠
- p.Thr293Ile Single submitter ⚠
- p.Thr337Ile Single submitter ⚠
- p.Thr540Met Single submitter ⚠
- p.Thr685Pro Single submitter ⚠
- p.Thr746Ala Single submitter ⚠
- p.Thr794Pro Single submitter ⚠
- p.Thr797Ile Single submitter ⚠
- p.Trp255Arg Single submitter ⚠
- p.Trp5Leu Single submitter ⚠
- p.Val181Glu Single submitter ⚠
- p.Val269Ala Single submitter ⚠
- p.Val269Met Single submitter ⚠
- p.Val384Ile Single submitter ⚠
- p.Val384Phe Single submitter ⚠
- p.Val507Met Single submitter ⚠
- p.Val699Ala Single submitter ⚠
- p.Val699Ile Single submitter ⚠
- p.Val735Ala Single submitter ⚠
- p.Val74Ala Single submitter ⚠
- p.Val87Glu Single submitter ⚠
- p.Val900Met Single submitter ⚠