ADAP1 — 56 ClinVar variants
All ClinVar germline ADAP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
2 Benign · 3 Likely benign · 51 Uncertain significance
Full ADAP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAP1 p.Ala293Val Uncertain significance Single submitter
- ADAP1 p.Ala81Val Uncertain significance Single submitter
- ADAP1 p.Arg139Cys Uncertain significance Single submitter
- ADAP1 p.Arg149Gln Uncertain significance Single submitter
- ADAP1 p.Arg206His Uncertain significance Single submitter
- ADAP1 p.Arg229Cys Uncertain significance Single submitter
- ADAP1 p.Arg49Gln Uncertain significance Single submitter
- ADAP1 p.Asn143Lys Uncertain significance Single submitter
- ADAP1 p.Asn164Ser Uncertain significance Single submitter
- ADAP1 p.Asn203Ser Uncertain significance Single submitter
- ADAP1 p.Asp142Glu Uncertain significance Single submitter
- ADAP1 p.Gln102His Uncertain significance Single submitter
- ADAP1 p.His179Arg Uncertain significance Single submitter
- ADAP1 p.Ile177Val Uncertain significance Single submitter
- ADAP1 p.Ile299Thr Uncertain significance Single submitter
- ADAP1 p.Lys333Asn Uncertain significance Single submitter
- ADAP1 p.Phe163Leu Uncertain significance Single submitter
- ADAP1 p.Pro126Leu Uncertain significance Single submitter
- ADAP1 p.Pro29Ser Uncertain significance Single submitter
- ADAP1 p.Ser128Leu Uncertain significance Single submitter
- ADAP1 p.Tyr127Ser Uncertain significance Single submitter
- ADAP1 p.Val348Met Uncertain significance Single submitter
- ADAP1 p.Val38Ile Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- ADAP1 p.Ala182Thr Uncertain significance Single submitter
- ADAP1 p.Ala243Thr Uncertain significance Single submitter
- ADAP1 p.Ala26Val Uncertain significance Single submitter
- ADAP1 p.Ala349Val Uncertain significance Single submitter
- ADAP1 p.Ala81Glu Uncertain significance Single submitter
- ADAP1 p.Arg132Cys Uncertain significance Single submitter
- ADAP1 p.Arg139Gly Uncertain significance Single submitter
- ADAP1 p.Arg226Gln Uncertain significance Single submitter
- ADAP1 p.Arg271Gln Uncertain significance Single submitter
- ADAP1 p.Arg95Gln Uncertain significance Single submitter
- ADAP1 p.Asn223Ser Uncertain significance Single submitter
- ADAP1 p.Asp331Asn Uncertain significance Single submitter
- ADAP1 p.Asp79Asn Uncertain significance Single submitter
- ADAP1 p.Gln116Arg Uncertain significance Single submitter
- ADAP1 p.Gln362Arg Uncertain significance Single submitter
- ADAP1 p.Glu213Gln Uncertain significance Single submitter
- ADAP1 p.Glu339Lys Uncertain significance Single submitter
- ADAP1 p.Gly190Ser Uncertain significance Single submitter
- ADAP1 p.His179Gln Uncertain significance Single submitter
- ADAP1 p.Leu13Gln Uncertain significance Single submitter
- ADAP1 p.Lys150Arg Uncertain significance Single submitter
- ADAP1 p.Lys302Asn Uncertain significance Single submitter
- ADAP1 p.Met175Ile Uncertain significance Single submitter
- ADAP1 p.Met175Val Uncertain significance Single submitter
- ADAP1 p.Pro314Leu Uncertain significance Single submitter
- ADAP1 p.Thr267Arg Uncertain significance Single submitter
- ADAP1 p.Tyr131Cys Uncertain significance Single submitter
- ADAP1 p.Val70Met Uncertain significance Single submitter
All ADAP1 variants
Benign 2
- c.389-8C>G Single submitter
- p.Thr307= Single submitter
Likely benign 3
- p.Ala354Val Single submitter
- p.Asn78= Single submitter
- p.Ser91Pro Single submitter
Uncertain significance 51
- p.Ala182Thr Single submitter ⚠
- p.Ala243Thr Single submitter ⚠
- p.Ala26Val Single submitter ⚠
- p.Ala293Val Single submitter ⚠
- p.Ala349Val Single submitter ⚠
- p.Ala81Glu Single submitter ⚠
- p.Ala81Val Single submitter ⚠
- p.Arg132Cys Single submitter ⚠
- p.Arg139Cys Single submitter ⚠
- p.Arg139Gly Single submitter ⚠
- p.Arg149Gln Single submitter ⚠
- p.Arg206His Single submitter ⚠
- p.Arg226Gln Single submitter ⚠
- p.Arg229Cys Single submitter ⚠
- p.Arg271Gln Single submitter ⚠
- p.Arg49Gln Single submitter ⚠
- p.Arg95Gln Single submitter ⚠
- p.Asn143Lys Single submitter ⚠
- p.Asn164Ser Single submitter ⚠
- p.Asn203Ser Single submitter ⚠
- p.Asn223Ser Single submitter ⚠
- p.Asp142Glu Single submitter ⚠
- p.Asp331Asn Single submitter ⚠
- p.Asp79Asn Single submitter ⚠
- p.Gln102His Single submitter ⚠
- p.Gln116Arg Single submitter ⚠
- p.Gln362Arg Single submitter ⚠
- p.Glu213Gln Single submitter ⚠
- p.Glu339Lys Single submitter ⚠
- p.Gly190Ser Single submitter ⚠
- p.His179Arg Single submitter ⚠
- p.His179Gln Single submitter ⚠
- p.Ile177Val Single submitter ⚠
- p.Ile299Thr Single submitter ⚠
- p.Leu13Gln Single submitter ⚠
- p.Lys150Arg Single submitter ⚠
- p.Lys302Asn Single submitter ⚠
- p.Lys333Asn Single submitter ⚠
- p.Met175Ile Single submitter ⚠
- p.Met175Val Single submitter ⚠
- p.Phe163Leu Single submitter ⚠
- p.Pro126Leu Single submitter ⚠
- p.Pro29Ser Single submitter ⚠
- p.Pro314Leu Single submitter ⚠
- p.Ser128Leu Single submitter ⚠
- p.Thr267Arg Single submitter ⚠
- p.Tyr127Ser Single submitter ⚠
- p.Tyr131Cys Single submitter ⚠
- p.Val348Met Single submitter ⚠
- p.Val38Ile Single submitter ⚠
- p.Val70Met Single submitter ⚠