ADAP2 — 53 ClinVar variants
All ClinVar germline ADAP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
2 Likely benign · 51 Uncertain significance
Full ADAP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAP2 p.Ala279Thr Uncertain significance Single submitter
- ADAP2 p.Arg16Gly Uncertain significance Single submitter
- ADAP2 p.Arg209Lys Uncertain significance Single submitter
- ADAP2 p.Arg229His Uncertain significance Single submitter
- ADAP2 p.Arg254Lys Uncertain significance Single submitter
- ADAP2 p.Arg322Gln Uncertain significance Single submitter
- ADAP2 p.Arg357Gln Uncertain significance Single submitter
- ADAP2 p.Arg378Ser Uncertain significance Single submitter
- ADAP2 p.Asn80Ser Uncertain significance Single submitter
- ADAP2 p.Asp27Asn Uncertain significance Single submitter
- ADAP2 p.Asp316Asn Uncertain significance Single submitter
- ADAP2 p.Glu315Lys Uncertain significance Single submitter
- ADAP2 p.Gly161Val Uncertain significance Single submitter
- ADAP2 p.Gly300Val Uncertain significance Single submitter
- ADAP2 p.Ile73Thr Uncertain significance Single submitter
- ADAP2 p.Ile73Val Uncertain significance Single submitter
- ADAP2 p.Leu106Val Uncertain significance Single submitter
- ADAP2 p.Leu131Phe Uncertain significance Single submitter
- ADAP2 p.Leu139Pro Uncertain significance Single submitter
- ADAP2 p.Met262Thr Uncertain significance Single submitter
- ADAP2 p.Pro132Ser Uncertain significance Single submitter
- ADAP2 p.Ser173Ile Uncertain significance Single submitter
- ADAP2 p.Ser179Arg Uncertain significance Single submitter
- ADAP2 p.Ser217Asn Uncertain significance Single submitter
- ADAP2 p.Val222Glu Uncertain significance Single submitter
- ADAP2 p.Val340Leu Uncertain significance Single submitter
- ADAP2 p.Val64Leu Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- ADAP2 p.Ala36Ser Uncertain significance Single submitter
- ADAP2 p.Arg285Gln Uncertain significance Single submitter
- ADAP2 p.Arg322Gly Uncertain significance Single submitter
- ADAP2 p.Arg338Gly Uncertain significance Single submitter
- ADAP2 p.Arg369Trp Uncertain significance Single submitter
- ADAP2 p.Arg84Cys Uncertain significance Single submitter
- ADAP2 p.Arg84His Uncertain significance Single submitter
- ADAP2 p.Asp145Gly Uncertain significance Single submitter
- ADAP2 p.Asp34Asn Uncertain significance Single submitter
- ADAP2 p.Asp71His Uncertain significance Single submitter
- ADAP2 p.Glu298Lys Uncertain significance Single submitter
- ADAP2 p.Gly21Ser Uncertain significance Single submitter
- ADAP2 p.Gly29Arg Uncertain significance Single submitter
- ADAP2 p.Gly310Val Uncertain significance Single submitter
- ADAP2 p.Ile200Val Uncertain significance Single submitter
- ADAP2 p.Ile99Leu Uncertain significance Single submitter
- ADAP2 p.Leu14Val Uncertain significance Single submitter
- ADAP2 p.Leu248Phe Uncertain significance Single submitter
- ADAP2 p.Leu341Phe Likely benign Single submitter
- ADAP2 p.Lys86Asn Uncertain significance Single submitter
- ADAP2 p.Met77Leu Uncertain significance Single submitter
- ADAP2 p.Ser217Arg Uncertain significance Single submitter
- ADAP2 p.Ser345Ile Uncertain significance Single submitter
- ADAP2 p.Tyr214Cys Uncertain significance Single submitter
- ADAP2 p.Tyr214His Uncertain significance Single submitter
All ADAP2 variants
Likely benign 2
- p.Arg120Gln Single submitter
- p.Leu341Phe Single submitter ⚠
Uncertain significance 51
- p.Ala279Thr Single submitter ⚠
- p.Ala36Ser Single submitter ⚠
- p.Arg16Gly Single submitter ⚠
- p.Arg209Lys Single submitter ⚠
- p.Arg229His Single submitter ⚠
- p.Arg254Lys Single submitter ⚠
- p.Arg285Gln Single submitter ⚠
- p.Arg322Gln Single submitter ⚠
- p.Arg322Gly Single submitter ⚠
- p.Arg338Gly Single submitter ⚠
- p.Arg357Gln Single submitter ⚠
- p.Arg369Trp Single submitter ⚠
- p.Arg378Ser Single submitter ⚠
- p.Arg84Cys Single submitter ⚠
- p.Arg84His Single submitter ⚠
- p.Asn80Ser Single submitter ⚠
- p.Asp145Gly Single submitter ⚠
- p.Asp27Asn Single submitter ⚠
- p.Asp316Asn Single submitter ⚠
- p.Asp34Asn Single submitter ⚠
- p.Asp71His Single submitter ⚠
- p.Glu298Lys Single submitter ⚠
- p.Glu315Lys Single submitter ⚠
- p.Gly161Val Single submitter ⚠
- p.Gly21Ser Single submitter ⚠
- p.Gly29Arg Single submitter ⚠
- p.Gly300Val Single submitter ⚠
- p.Gly310Val Single submitter ⚠
- p.Ile200Val Single submitter ⚠
- p.Ile73Thr Single submitter ⚠
- p.Ile73Val Single submitter ⚠
- p.Ile99Leu Single submitter ⚠
- p.Leu106Val Single submitter ⚠
- p.Leu131Phe Single submitter ⚠
- p.Leu139Pro Single submitter ⚠
- p.Leu14Val Single submitter ⚠
- p.Leu248Phe Single submitter ⚠
- p.Lys86Asn Single submitter ⚠
- p.Met262Thr Single submitter ⚠
- p.Met77Leu Single submitter ⚠
- p.Pro132Ser Single submitter ⚠
- p.Ser173Ile Single submitter ⚠
- p.Ser179Arg Single submitter ⚠
- p.Ser217Arg Single submitter ⚠
- p.Ser217Asn Single submitter ⚠
- p.Ser345Ile Single submitter ⚠
- p.Tyr214Cys Single submitter ⚠
- p.Tyr214His Single submitter ⚠
- p.Val222Glu Single submitter ⚠
- p.Val340Leu Single submitter ⚠
- p.Val64Leu Single submitter ⚠