ADARB2 — 152 ClinVar variants

All ClinVar germline ADARB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 141 flagged for review →

6 Benign · 8 Likely benign · 138 Uncertain significance

Full ADARB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 141

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 59

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 82

The independent predictors disagree with each other — read with care.

All ADARB2 variants

Benign 6

p.Arg328= Multiple submitters
p.Arg657Gln Multiple submitters
p.Glu300Lys Multiple submitters ⚠
p.Ser463= Multiple submitters
p.Val155= Multiple submitters
p.Arg374= Single submitter

Likely benign 8

p.Ala125= Multiple submitters
p.Ala646Val Single submitter ⚠
p.Arg259His Single submitter ⚠
p.Asp400= Single submitter
p.Gly252Arg Single submitter
p.Ile38Met Single submitter
p.Pro83Leu Single submitter
p.Thr378Met Single submitter

Uncertain significance 138

p.Arg457His Multiple submitters ⚠
p.Arg457Ser Multiple submitters ⚠
p.Ala195Val Single submitter ⚠
p.Ala352Gly Single submitter ⚠
p.Ala362Thr Single submitter ⚠
p.Ala433Val Single submitter ⚠
p.Ala440Gly Single submitter ⚠
p.Ala537Thr Single submitter ⚠
p.Ala611Pro Single submitter ⚠
p.Ala611Val Single submitter ⚠
p.Ala628Val Single submitter ⚠
p.Ala646Thr Single submitter ⚠
p.Arg100Leu Single submitter ⚠
p.Arg143Gln Single submitter ⚠
p.Arg143Gly Single submitter ⚠
p.Arg143Trp Single submitter ⚠
p.Arg187Gly Single submitter ⚠
p.Arg254Pro Single submitter ⚠
p.Arg255Gln Single submitter ⚠
p.Arg259Cys Single submitter ⚠
p.Arg25Ser Single submitter ⚠
p.Arg26Lys Single submitter ⚠
p.Arg287Cys Single submitter ⚠
p.Arg322His Single submitter ⚠
p.Arg322Leu Single submitter ⚠
p.Arg374Cys Single submitter ⚠
p.Arg386Cys Single submitter ⚠
p.Arg386Gly Single submitter ⚠
p.Arg386His Single submitter ⚠
p.Arg402Leu Single submitter ⚠
p.Arg438Gln Single submitter ⚠
p.Arg439Pro Single submitter ⚠
p.Arg456Leu Single submitter ⚠
p.Arg457Cys Single submitter ⚠
p.Arg462Gln Single submitter ⚠
p.Arg467Trp Single submitter ⚠
p.Arg476Gln Single submitter ⚠
p.Arg516Cys Single submitter ⚠
p.Arg516Gly Single submitter ⚠
p.Arg516His Single submitter ⚠
p.Arg533His Single submitter ⚠
p.Arg617Gln Single submitter ⚠
p.Arg617Trp Single submitter ⚠
p.Arg629His Single submitter ⚠
p.Arg674Gln Single submitter ⚠
p.Arg677Gln Single submitter ⚠
p.Arg677Trp Single submitter ⚠
p.Arg685Gln Single submitter ⚠
p.Arg685Gly Single submitter ⚠
p.Arg73Cys Single submitter ⚠
p.Arg81Gln Single submitter ⚠
p.Arg81Pro Single submitter ⚠
p.Arg88Pro Single submitter ⚠
p.Arg90Trp Single submitter ⚠
p.Asn652Lys Single submitter ⚠
p.Asn74Ile Single submitter ⚠
p.Asp218Glu Single submitter ⚠
p.Asp400Asn Single submitter ⚠
p.Asp400His Single submitter ⚠
p.Asp60Asn Single submitter ⚠
p.Asp691Asn Single submitter ⚠
p.Cys196Tyr Single submitter ⚠
p.Cys697Arg Single submitter ⚠
p.Gln114Arg Single submitter ⚠
p.Gln359Pro Single submitter ⚠
p.Gln734Leu Single submitter ⚠
p.Glu375Lys Single submitter ⚠
p.Glu419Lys Single submitter ⚠
p.Glu500Lys Single submitter ⚠
p.Glu524Asp Single submitter ⚠
p.Gly205Asp Single submitter ⚠
p.Gly242Glu Single submitter ⚠
p.Gly314Asp Single submitter ⚠
p.Gly329Asp Single submitter ⚠
p.Gly346Ser Single submitter ⚠
p.Gly471Asp Single submitter ⚠
p.Gly472Asp Single submitter ⚠
p.Gly472Ser Single submitter ⚠
p.Gly526Arg Single submitter ⚠
p.Gly644Ala Single submitter ⚠
p.Gly644Asp Single submitter ⚠
p.Gly690Arg Single submitter ⚠
p.Gly6Glu Single submitter ⚠
p.Gly702Arg Single submitter ⚠
p.Gly76Asp Single submitter ⚠
p.Gly8Val Single submitter ⚠
p.Gly95Cys Single submitter ⚠
p.His152Pro Single submitter ⚠
p.His443Asn Single submitter ⚠
p.His594Gln Single submitter ⚠
p.Ile38Val Single submitter ⚠
p.Ile464Leu Single submitter ⚠
p.Leu102Arg Single submitter ⚠
p.Leu165Phe Single submitter ⚠
p.Leu223Val Single submitter ⚠
p.Leu39Ser Single submitter ⚠
p.Leu409Val Single submitter ⚠
p.Leu495Phe Single submitter ⚠
p.Lys178Glu Single submitter ⚠
p.Lys372Asn Single submitter ⚠
p.Lys668Gln Single submitter ⚠
p.Lys99Thr Single submitter ⚠
p.Met179Leu Single submitter ⚠
p.Met639Thr Single submitter ⚠
p.Met695Thr Single submitter ⚠
p.Phe167Ile Single submitter ⚠
p.Pro138Arg Single submitter ⚠
p.Pro271Arg Single submitter ⚠
p.Pro349Leu Single submitter ⚠
p.Pro730Ser Single submitter ⚠
p.Ser15Asn Single submitter ⚠
p.Ser320Leu Single submitter ⚠
p.Ser634Leu Single submitter ⚠
p.Thr148Met Single submitter ⚠
p.Thr267Ile Single submitter ⚠
p.Thr316Arg Single submitter ⚠
p.Thr377Met Single submitter ⚠
p.Thr503Arg Single submitter ⚠
p.Thr529Lys Single submitter ⚠
p.Thr692Met Single submitter ⚠
p.Trp122Arg Single submitter ⚠
p.Val155Ile Single submitter ⚠
p.Val369Phe Single submitter ⚠
p.Val36Ala Single submitter ⚠
p.Val394Ile Single submitter ⚠
p.Val407Leu Single submitter ⚠
p.Val407Met Single submitter ⚠
p.Val436Met Single submitter ⚠
p.Val485Leu Single submitter ⚠
p.Val485Met Single submitter ⚠
p.Val512Ile Single submitter ⚠
p.Val530Ala Single submitter ⚠
p.Val532Met Single submitter ⚠
p.Val576Met Single submitter ⚠
p.Val623Met Single submitter ⚠
p.Val643Met Single submitter ⚠
p.Val670Met Single submitter ⚠
p.Val69Leu Single submitter ⚠