ADAT2 — 26 ClinVar variants
All ClinVar germline ADAT2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
26 Uncertain significance
Full ADAT2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAT2 p.Ala19Thr Uncertain significance Single submitter
- ADAT2 p.Ala6Val Uncertain significance Single submitter
- ADAT2 p.Arg115Cys Uncertain significance Single submitter
- ADAT2 p.Arg130Gln Uncertain significance Single submitter
- ADAT2 p.Asp78Asn Uncertain significance Single submitter
- ADAT2 p.Cys126Tyr Uncertain significance Single submitter
- ADAT2 p.Glu105Lys Uncertain significance Single submitter
- ADAT2 p.His97Arg Uncertain significance Single submitter
- ADAT2 p.Ile155Val Uncertain significance Single submitter
- ADAT2 p.Met117Ile Uncertain significance Single submitter
- ADAT2 p.Pro9Thr Uncertain significance Single submitter
- ADAT2 p.Ser92Pro Uncertain significance Single submitter
- ADAT2 p.Tyr124His Uncertain significance Single submitter
- ADAT2 p.Val183Gly Uncertain significance Single submitter
- ADAT2 p.Val44Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- ADAT2 p.Ala5Val Uncertain significance Single submitter
- ADAT2 p.Arg184Gln Uncertain significance Single submitter
- ADAT2 p.Arg184Trp Uncertain significance Single submitter
- ADAT2 p.Arg70Gln Uncertain significance Single submitter
- ADAT2 p.Gln79Glu Uncertain significance Single submitter
- ADAT2 p.Lys172Asn Uncertain significance Single submitter
- ADAT2 p.Lys24Asn Uncertain significance Single submitter
- ADAT2 p.Lys24Glu Uncertain significance Single submitter
- ADAT2 p.Met30Ile Uncertain significance Single submitter
- ADAT2 p.Met74Ile Uncertain significance Single submitter
- ADAT2 p.Val104Leu Uncertain significance Single submitter
All ADAT2 variants
Uncertain significance 26
- p.Ala19Thr Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Arg115Cys Single submitter ⚠
- p.Arg130Gln Single submitter ⚠
- p.Arg184Gln Single submitter ⚠
- p.Arg184Trp Single submitter ⚠
- p.Arg70Gln Single submitter ⚠
- p.Asp78Asn Single submitter ⚠
- p.Cys126Tyr Single submitter ⚠
- p.Gln79Glu Single submitter ⚠
- p.Glu105Lys Single submitter ⚠
- p.His97Arg Single submitter ⚠
- p.Ile155Val Single submitter ⚠
- p.Lys172Asn Single submitter ⚠
- p.Lys24Asn Single submitter ⚠
- p.Lys24Glu Single submitter ⚠
- p.Met117Ile Single submitter ⚠
- p.Met30Ile Single submitter ⚠
- p.Met74Ile Single submitter ⚠
- p.Pro9Thr Single submitter ⚠
- p.Ser92Pro Single submitter ⚠
- p.Tyr124His Single submitter ⚠
- p.Val104Leu Single submitter ⚠
- p.Val183Gly Single submitter ⚠
- p.Val44Leu Single submitter ⚠