ADCK5 — 96 ClinVar variants
All ClinVar germline ADCK5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
8 Likely benign · 88 Uncertain significance
Full ADCK5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADCK5 p.Ala131Val Uncertain significance Single submitter
- ADCK5 p.Ala319Thr Uncertain significance Single submitter
- ADCK5 p.Ala418Thr Uncertain significance Single submitter
- ADCK5 p.Ala508Val Uncertain significance Single submitter
- ADCK5 p.Ala518Pro Uncertain significance Single submitter
- ADCK5 p.Ala518Thr Uncertain significance Single submitter
- ADCK5 p.Ala532Thr Uncertain significance Single submitter
- ADCK5 p.Ala54Val Uncertain significance Single submitter
- ADCK5 p.Ala556Thr Uncertain significance Single submitter
- ADCK5 p.Arg168His Uncertain significance Single submitter
- ADCK5 p.Arg31Ser Uncertain significance Single submitter
- ADCK5 p.Arg39Ser Uncertain significance Single submitter
- ADCK5 p.Arg402Gln Uncertain significance Single submitter
- ADCK5 p.Arg437His Uncertain significance Single submitter
- ADCK5 p.Arg460His Uncertain significance Single submitter
- ADCK5 p.Arg475Gln Uncertain significance Single submitter
- ADCK5 p.Arg500His Uncertain significance Single submitter
- ADCK5 p.Arg510Trp Uncertain significance Single submitter
- ADCK5 p.Arg72Trp Uncertain significance Single submitter
- ADCK5 p.Arg78Gln Uncertain significance Single submitter
- ADCK5 p.Asn32Tyr Uncertain significance Single submitter
- ADCK5 p.Asp172Asn Uncertain significance Single submitter
- ADCK5 p.Asp233Gly Uncertain significance Single submitter
- ADCK5 p.Asp409Ala Uncertain significance Single submitter
- ADCK5 p.Gln440Lys Uncertain significance Single submitter
- ADCK5 p.Gln96Arg Uncertain significance Single submitter
- ADCK5 p.Glu391Lys Uncertain significance Single submitter
- ADCK5 p.Glu464Asp Uncertain significance Single submitter
- ADCK5 p.Gly118Ala Uncertain significance Single submitter
- ADCK5 p.Gly374Arg Uncertain significance Single submitter
- ADCK5 p.Gly511Asp Uncertain significance Single submitter
- ADCK5 p.Gly525Arg Uncertain significance Single submitter
- ADCK5 p.Gly525Ser Uncertain significance Single submitter
- ADCK5 p.His157Tyr Uncertain significance Single submitter
- ADCK5 p.His16Asn Uncertain significance Single submitter
- ADCK5 p.His337Pro Uncertain significance Single submitter
- ADCK5 p.Ile339Thr Uncertain significance Single submitter
- ADCK5 p.Leu36Ile Uncertain significance Single submitter
- ADCK5 p.Leu397His Uncertain significance Single submitter
- ADCK5 p.Leu431Val Uncertain significance Single submitter
- ADCK5 p.Leu446Val Uncertain significance Single submitter
- ADCK5 p.Leu481Pro Uncertain significance Single submitter
- ADCK5 p.Leu562Pro Uncertain significance Single submitter
- ADCK5 p.Leu565Val Uncertain significance Single submitter
- ADCK5 p.Leu79Phe Uncertain significance Single submitter
- ADCK5 p.Lys370Gln Uncertain significance Single submitter
- ADCK5 p.Met455Val Uncertain significance Single submitter
- ADCK5 p.Met467Thr Uncertain significance Single submitter
- ADCK5 p.Met552Val Uncertain significance Single submitter
- ADCK5 p.Pro161Leu Uncertain significance Single submitter
- ADCK5 p.Pro23Leu Uncertain significance Single submitter
- ADCK5 p.Pro301Ala Uncertain significance Single submitter
- ADCK5 p.Pro372Leu Uncertain significance Single submitter
- ADCK5 p.Pro4Arg Uncertain significance Single submitter
- ADCK5 p.Ser24Tyr Uncertain significance Single submitter
- ADCK5 p.Ser331Asn Uncertain significance Single submitter
- ADCK5 p.Ser444Leu Uncertain significance Single submitter
- ADCK5 p.Thr105Ile Uncertain significance Single submitter
- ADCK5 p.Thr44Lys Uncertain significance Single submitter
- ADCK5 p.Thr53Ile Uncertain significance Single submitter
- ADCK5 p.Thr580Ile Uncertain significance Single submitter
- ADCK5 p.Tyr501Cys Uncertain significance Single submitter
- ADCK5 p.Tyr520Cys Uncertain significance Single submitter
- ADCK5 p.Val108Leu Uncertain significance Single submitter
- ADCK5 p.Val112Glu Uncertain significance Single submitter
- ADCK5 p.Val112Met Uncertain significance Single submitter
- ADCK5 p.Val33Ile Uncertain significance Single submitter
- ADCK5 p.Val466Ala Uncertain significance Single submitter
- ADCK5 p.Val492Met Uncertain significance Single submitter
- ADCK5 p.Val50Met Uncertain significance Single submitter
- ADCK5 p.Val543Ala Uncertain significance Single submitter
- ADCK5 p.Val568Leu Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- ADCK5 p.Ala417Asp Uncertain significance Single submitter
- ADCK5 p.Arg330Gly Uncertain significance Single submitter
- ADCK5 p.Arg413Thr Uncertain significance Single submitter
- ADCK5 p.Gly240Arg Uncertain significance Single submitter
- ADCK5 p.Gly333Glu Uncertain significance Single submitter
- ADCK5 p.Ile357Thr Uncertain significance Single submitter
- ADCK5 p.Met412Ile Uncertain significance Single submitter
- ADCK5 p.Met432Ile Uncertain significance Single submitter
- ADCK5 p.Met477Thr Uncertain significance Single submitter
- ADCK5 p.Met504Val Uncertain significance Single submitter
- ADCK5 p.Phe427Leu Uncertain significance Single submitter
- ADCK5 p.Pro117Leu Uncertain significance Single submitter
- ADCK5 p.Val421Leu Uncertain significance Single submitter
All ADCK5 variants
Likely benign 8
- c.1260_1267+7dup Single submitter
- p.Arg290Gln Single submitter
- p.Arg546= Single submitter
- p.Asn141= Single submitter
- p.His337Gln Single submitter
- p.Ser42Arg Single submitter
- p.Thr164Ile Single submitter
- p.Val466Ile Single submitter
Uncertain significance 88
- p.Ala131Val Single submitter ⚠
- p.Ala319Thr Single submitter ⚠
- p.Ala417Asp Single submitter ⚠
- p.Ala418Thr Single submitter ⚠
- p.Ala508Val Single submitter ⚠
- p.Ala518Pro Single submitter ⚠
- p.Ala518Thr Single submitter ⚠
- p.Ala532Thr Single submitter ⚠
- p.Ala54Val Single submitter ⚠
- p.Ala556Thr Single submitter ⚠
- p.Arg168His Single submitter ⚠
- p.Arg31Ser Single submitter ⚠
- p.Arg330Gly Single submitter ⚠
- p.Arg39Ser Single submitter ⚠
- p.Arg402Gln Single submitter ⚠
- p.Arg413Thr Single submitter ⚠
- p.Arg437His Single submitter ⚠
- p.Arg460His Single submitter ⚠
- p.Arg475Gln Single submitter ⚠
- p.Arg500His Single submitter ⚠
- p.Arg510Trp Single submitter ⚠
- p.Arg72Trp Single submitter ⚠
- p.Arg78Gln Single submitter ⚠
- p.Asn32Tyr Single submitter ⚠
- p.Asp172Asn Single submitter ⚠
- p.Asp233Gly Single submitter ⚠
- p.Asp409Ala Single submitter ⚠
- p.Gln440Lys Single submitter ⚠
- p.Gln96Arg Single submitter ⚠
- p.Glu391Lys Single submitter ⚠
- p.Glu464Asp Single submitter ⚠
- p.Glu542Lys Single submitter
- p.Gly118Ala Single submitter ⚠
- p.Gly240Arg Single submitter ⚠
- p.Gly333Glu Single submitter ⚠
- p.Gly374Arg Single submitter ⚠
- p.Gly511Asp Single submitter ⚠
- p.Gly525Arg Single submitter ⚠
- p.Gly525Ser Single submitter ⚠
- p.His157Tyr Single submitter ⚠
- p.His16Asn Single submitter ⚠
- p.His256Tyr Single submitter
- p.His337Pro Single submitter ⚠
- p.Ile339Thr Single submitter ⚠
- p.Ile357Thr Single submitter ⚠
- p.Leu36Ile Single submitter ⚠
- p.Leu397His Single submitter ⚠
- p.Leu431Val Single submitter ⚠
- p.Leu446Val Single submitter ⚠
- p.Leu481Pro Single submitter ⚠
- p.Leu562Pro Single submitter ⚠
- p.Leu565Val Single submitter ⚠
- p.Leu79Phe Single submitter ⚠
- p.Lys370Gln Single submitter ⚠
- p.Met412Ile Single submitter ⚠
- p.Met432Ile Single submitter ⚠
- p.Met455Val Single submitter ⚠
- p.Met467Thr Single submitter ⚠
- p.Met477Thr Single submitter ⚠
- p.Met504Val Single submitter ⚠
- p.Met552Val Single submitter ⚠
- p.Phe427Leu Single submitter ⚠
- p.Pro117Leu Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro301Ala Single submitter ⚠
- p.Pro372Leu Single submitter ⚠
- p.Pro4Arg Single submitter ⚠
- p.Ser24Tyr Single submitter ⚠
- p.Ser331Asn Single submitter ⚠
- p.Ser444Leu Single submitter ⚠
- p.Thr105Ile Single submitter ⚠
- p.Thr44Lys Single submitter ⚠
- p.Thr53Ile Single submitter ⚠
- p.Thr580Ile Single submitter ⚠
- p.Tyr501Cys Single submitter ⚠
- p.Tyr520Cys Single submitter ⚠
- p.Val108Leu Single submitter ⚠
- p.Val112Glu Single submitter ⚠
- p.Val112Met Single submitter ⚠
- p.Val33Ile Single submitter ⚠
- p.Val421Leu Single submitter ⚠
- p.Val466Ala Single submitter ⚠
- p.Val480Leu Single submitter
- p.Val492Met Single submitter ⚠
- p.Val50Met Single submitter ⚠
- p.Val543Ala Single submitter ⚠
- p.Val568Leu Single submitter ⚠