Sugi Variant

Sugi Variant/ADCY3

ADCY3 — 555 ClinVar variants

All ClinVar germline ADCY3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 245 flagged for review →

4 Pathogenic · 9 Likely pathogenic · 3 Conflicting · 24 Benign · 10 Benign/Likely benign · 220 Likely benign · 285 Uncertain significance

Full ADCY3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 245

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 192

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 192

Predictors split 51

The independent predictors disagree with each other — read with care.

All ADCY3 variants

Pathogenic 4

Likely pathogenic 9

Conflicting classifications of pathogenicity 3

Benign 24

Benign/Likely benign 10

Likely benign 220

Uncertain significance 285