ADCYAP1 — 24 ClinVar variants
All ClinVar germline ADCYAP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
2 Likely benign · 22 Uncertain significance
Full ADCYAP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADCYAP1 p.Ala29Val Uncertain significance Single submitter
- ADCYAP1 p.Ala61Ser Uncertain significance Single submitter
- ADCYAP1 p.Ala73Val Uncertain significance Single submitter
- ADCYAP1 p.Arg81Gly Uncertain significance Single submitter
- ADCYAP1 p.Arg93Leu Uncertain significance Single submitter
- ADCYAP1 p.Asn89Lys Uncertain significance Single submitter
- ADCYAP1 p.Asp52Asn Uncertain significance Single submitter
- ADCYAP1 p.Gly35Trp Uncertain significance Single submitter
- ADCYAP1 p.Lys94Gln Uncertain significance Single submitter
- ADCYAP1 p.Pro51Ser Uncertain significance Single submitter
- ADCYAP1 p.Pro58Thr Uncertain significance Single submitter
- ADCYAP1 p.Pro59Arg Uncertain significance Single submitter
- ADCYAP1 p.Pro77Ser Uncertain significance Single submitter
- ADCYAP1 p.Ser107Leu Uncertain significance Single submitter
- ADCYAP1 p.Val22Ala Uncertain significance Single submitter
- ADCYAP1 p.Val95Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ADCYAP1 p.Arg145Gly Uncertain significance Single submitter
- ADCYAP1 p.Arg172Gly Uncertain significance Single submitter
- ADCYAP1 p.Arg93Cys Uncertain significance Single submitter
- ADCYAP1 p.Gln147Glu Uncertain significance Single submitter
- ADCYAP1 p.Ser24Arg Uncertain significance Single submitter
- ADCYAP1 p.Val157Phe Uncertain significance Single submitter
All ADCYAP1 variants
Likely benign 2
- p.Asn89= Single submitter
- p.Asp123Glu Single submitter
Uncertain significance 22
- p.Ala29Val Single submitter ⚠
- p.Ala61Ser Single submitter ⚠
- p.Ala73Val Single submitter ⚠
- p.Arg145Gly Single submitter ⚠
- p.Arg172Gly Single submitter ⚠
- p.Arg81Gly Single submitter ⚠
- p.Arg93Cys Single submitter ⚠
- p.Arg93Leu Single submitter ⚠
- p.Asn89Lys Single submitter ⚠
- p.Asp52Asn Single submitter ⚠
- p.Gln147Glu Single submitter ⚠
- p.Gly35Trp Single submitter ⚠
- p.Lys94Gln Single submitter ⚠
- p.Pro51Ser Single submitter ⚠
- p.Pro58Thr Single submitter ⚠
- p.Pro59Arg Single submitter ⚠
- p.Pro77Ser Single submitter ⚠
- p.Ser107Leu Single submitter ⚠
- p.Ser24Arg Single submitter ⚠
- p.Val157Phe Single submitter ⚠
- p.Val22Ala Single submitter ⚠
- p.Val95Ala Single submitter ⚠