ADGRA1 — 118 ClinVar variants
All ClinVar germline ADGRA1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 106 flagged for review →
1 Benign · 6 Likely benign · 111 Uncertain significance
Full ADGRA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 106
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 100
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADGRA1 p.Ala105Thr Uncertain significance Single submitter
- ADGRA1 p.Ala116Thr Uncertain significance Single submitter
- ADGRA1 p.Ala151Gly Uncertain significance Single submitter
- ADGRA1 p.Ala166Val Uncertain significance Single submitter
- ADGRA1 p.Ala259Thr Uncertain significance Single submitter
- ADGRA1 p.Ala260Asp Uncertain significance Single submitter
- ADGRA1 p.Ala260Thr Uncertain significance Single submitter
- ADGRA1 p.Ala26Thr Uncertain significance Single submitter
- ADGRA1 p.Ala293Thr Uncertain significance Single submitter
- ADGRA1 p.Ala327Thr Uncertain significance Single submitter
- ADGRA1 p.Ala327Val Uncertain significance Single submitter
- ADGRA1 p.Ala330Glu Uncertain significance Single submitter
- ADGRA1 p.Ala341Thr Uncertain significance Single submitter
- ADGRA1 p.Ala369Ser Uncertain significance Single submitter
- ADGRA1 p.Ala370Thr Uncertain significance Single submitter
- ADGRA1 p.Ala370Val Uncertain significance Single submitter
- ADGRA1 p.Ala374Thr Uncertain significance Single submitter
- ADGRA1 p.Ala385Thr Uncertain significance Single submitter
- ADGRA1 p.Ala394Thr Uncertain significance Single submitter
- ADGRA1 p.Ala394Val Uncertain significance Single submitter
- ADGRA1 p.Ala464Thr Uncertain significance Single submitter
- ADGRA1 p.Ala64Thr Uncertain significance Single submitter
- ADGRA1 p.Ala71Thr Uncertain significance Single submitter
- ADGRA1 p.Arg11His Uncertain significance Single submitter
- ADGRA1 p.Arg202Trp Uncertain significance Single submitter
- ADGRA1 p.Arg207His Uncertain significance Single submitter
- ADGRA1 p.Arg212Cys Uncertain significance Single submitter
- ADGRA1 p.Arg212His Uncertain significance Single submitter
- ADGRA1 p.Arg220Gln Uncertain significance Single submitter
- ADGRA1 p.Arg220Trp Uncertain significance Single submitter
- ADGRA1 p.Arg228Cys Uncertain significance Single submitter
- ADGRA1 p.Arg231Gln Uncertain significance Single submitter
- ADGRA1 p.Arg257Cys Uncertain significance Single submitter
- ADGRA1 p.Arg428Gln Uncertain significance Single submitter
- ADGRA1 p.Arg428Pro Uncertain significance Single submitter
- ADGRA1 p.Arg428Trp Uncertain significance Single submitter
- ADGRA1 p.Arg449Cys Uncertain significance Single submitter
- ADGRA1 p.Arg452Cys Uncertain significance Single submitter
- ADGRA1 p.Arg47Cys Uncertain significance Single submitter
- ADGRA1 p.Arg502Lys Uncertain significance Single submitter
- ADGRA1 p.Arg50His Uncertain significance Single submitter
- ADGRA1 p.Arg515Gln Uncertain significance Single submitter
- ADGRA1 p.Arg515Trp Uncertain significance Single submitter
- ADGRA1 p.Arg53Trp Uncertain significance Single submitter
- ADGRA1 p.Asn75Ser Uncertain significance Single submitter
- ADGRA1 p.Asp410Asn Uncertain significance Single submitter
- ADGRA1 p.Asp488Val Uncertain significance Single submitter
- ADGRA1 p.Cys119Trp Uncertain significance Single submitter
- ADGRA1 p.Gln111His Uncertain significance Single submitter
- ADGRA1 p.Gln351Arg Uncertain significance Single submitter
- ADGRA1 p.Gln368His Uncertain significance Single submitter
- ADGRA1 p.Glu163Lys Uncertain significance Single submitter
- ADGRA1 p.Glu390Lys Uncertain significance Single submitter
- ADGRA1 p.Gly102Ala Uncertain significance Single submitter
- ADGRA1 p.Gly242Ser Uncertain significance Single submitter
- ADGRA1 p.Gly280Asp Uncertain significance Single submitter
- ADGRA1 p.Gly335Arg Uncertain significance Single submitter
- ADGRA1 p.Gly350Cys Uncertain significance Single submitter
- ADGRA1 p.Gly408Arg Uncertain significance Single submitter
- ADGRA1 p.Gly419Asp Uncertain significance Single submitter
- ADGRA1 p.Gly465Arg Uncertain significance Single submitter
- ADGRA1 p.Gly486Asp Uncertain significance Single submitter
- ADGRA1 p.Gly486Ser Uncertain significance Single submitter
- ADGRA1 p.Gly507Arg Uncertain significance Single submitter
- ADGRA1 p.Gly509Ser Uncertain significance Single submitter
- ADGRA1 p.Gly538Ala Uncertain significance Single submitter
- ADGRA1 p.Gly545Glu Uncertain significance Single submitter
- ADGRA1 p.Gly547Ser Uncertain significance Single submitter
- ADGRA1 p.His398Gln Uncertain significance Single submitter
- ADGRA1 p.Ile440Phe Uncertain significance Single submitter
- ADGRA1 p.Leu539Val Uncertain significance Single submitter
- ADGRA1 p.Lys78Glu Uncertain significance Single submitter
- ADGRA1 p.Met285Val Uncertain significance Single submitter
- ADGRA1 p.Met513Thr Uncertain significance Single submitter
- ADGRA1 p.Phe144Cys Uncertain significance Single submitter
- ADGRA1 p.Pro128Leu Uncertain significance Single submitter
- ADGRA1 p.Pro174Ser Uncertain significance Single submitter
- ADGRA1 p.Pro19Arg Uncertain significance Single submitter
- ADGRA1 p.Pro235Ser Uncertain significance Single submitter
- ADGRA1 p.Pro322Leu Uncertain significance Single submitter
- ADGRA1 p.Pro359Leu Uncertain significance Single submitter
- ADGRA1 p.Pro361Thr Uncertain significance Single submitter
- ADGRA1 p.Pro391Thr Uncertain significance Single submitter
- ADGRA1 p.Pro423Ala Uncertain significance Single submitter
- ADGRA1 p.Pro457Ser Uncertain significance Single submitter
- ADGRA1 p.Pro540Leu Uncertain significance Single submitter
- ADGRA1 p.Pro553Arg Uncertain significance Single submitter
- ADGRA1 p.Ser490Arg Uncertain significance Single submitter
- ADGRA1 p.Thr104Ser Uncertain significance Single submitter
- ADGRA1 p.Thr165Met Uncertain significance Single submitter
- ADGRA1 p.Thr25Met Uncertain significance Single submitter
- ADGRA1 p.Thr393Lys Uncertain significance Single submitter
- ADGRA1 p.Thr498Met Uncertain significance Single submitter
- ADGRA1 p.Thr543Ser Uncertain significance Single submitter
- ADGRA1 p.Thr77Ala Uncertain significance Single submitter
- ADGRA1 p.Trp270Cys Uncertain significance Single submitter
- ADGRA1 p.Val138Ala Uncertain significance Single submitter
- ADGRA1 p.Val199Met Uncertain significance Single submitter
- ADGRA1 p.Val313Met Uncertain significance Single submitter
- ADGRA1 p.Val481Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ADGRA1 p.Arg203His Uncertain significance Single submitter
- ADGRA1 p.Glu249Asp Uncertain significance Single submitter
- ADGRA1 p.Gly181Ser Uncertain significance Single submitter
- ADGRA1 p.Gly552Arg Uncertain significance Single submitter
- ADGRA1 p.Pro205Ser Uncertain significance Single submitter
- ADGRA1 p.Thr150Met Uncertain significance Single submitter
All ADGRA1 variants
Benign 1
- p.Gly72Ser Multiple submitters
Likely benign 6
- p.Arg219Gln Single submitter
- p.Arg340= Single submitter
- p.Arg449His Single submitter
- p.Gly372Ser Single submitter
- p.Lys555Arg Single submitter
- p.Val37Ile Single submitter
Uncertain significance 111
- p.Ala105Thr Single submitter ⚠
- p.Ala116Thr Single submitter ⚠
- p.Ala151Gly Single submitter ⚠
- p.Ala166Val Single submitter ⚠
- p.Ala259Thr Single submitter ⚠
- p.Ala260Asp Single submitter ⚠
- p.Ala260Thr Single submitter ⚠
- p.Ala26Thr Single submitter ⚠
- p.Ala293Thr Single submitter ⚠
- p.Ala327Thr Single submitter ⚠
- p.Ala327Val Single submitter ⚠
- p.Ala330Glu Single submitter ⚠
- p.Ala341Thr Single submitter ⚠
- p.Ala369Ser Single submitter ⚠
- p.Ala370Thr Single submitter ⚠
- p.Ala370Val Single submitter ⚠
- p.Ala374Thr Single submitter ⚠
- p.Ala385Thr Single submitter ⚠
- p.Ala394Thr Single submitter ⚠
- p.Ala394Val Single submitter ⚠
- p.Ala464Thr Single submitter ⚠
- p.Ala64Thr Single submitter ⚠
- p.Ala71Thr Single submitter ⚠
- p.Arg11His Single submitter ⚠
- p.Arg202Trp Single submitter ⚠
- p.Arg203His Single submitter ⚠
- p.Arg207His Single submitter ⚠
- p.Arg212Cys Single submitter ⚠
- p.Arg212His Single submitter ⚠
- p.Arg220Gln Single submitter ⚠
- p.Arg220Trp Single submitter ⚠
- p.Arg228Cys Single submitter ⚠
- p.Arg231Gln Single submitter ⚠
- p.Arg257Cys Single submitter ⚠
- p.Arg428Gln Single submitter ⚠
- p.Arg428Pro Single submitter ⚠
- p.Arg428Trp Single submitter ⚠
- p.Arg449Cys Single submitter ⚠
- p.Arg452Cys Single submitter ⚠
- p.Arg47Cys Single submitter ⚠
- p.Arg502Lys Single submitter ⚠
- p.Arg50His Single submitter ⚠
- p.Arg515Gln Single submitter ⚠
- p.Arg515Trp Single submitter ⚠
- p.Arg53Trp Single submitter ⚠
- p.Asn75Ser Single submitter ⚠
- p.Asp410Asn Single submitter ⚠
- p.Asp488Val Single submitter ⚠
- p.Cys119Trp Single submitter ⚠
- p.Cys362Tyr Single submitter
- p.Gln111His Single submitter ⚠
- p.Gln351Arg Single submitter ⚠
- p.Gln368His Single submitter ⚠
- p.Glu163Lys Single submitter ⚠
- p.Glu249Asp Single submitter ⚠
- p.Glu390Lys Single submitter ⚠
- p.Gly102Ala Single submitter ⚠
- p.Gly181Ser Single submitter ⚠
- p.Gly242Ser Single submitter ⚠
- p.Gly280Asp Single submitter ⚠
- p.Gly335Arg Single submitter ⚠
- p.Gly350Cys Single submitter ⚠
- p.Gly408Arg Single submitter ⚠
- p.Gly419Asp Single submitter ⚠
- p.Gly465Arg Single submitter ⚠
- p.Gly486Asp Single submitter ⚠
- p.Gly486Ser Single submitter ⚠
- p.Gly507Arg Single submitter ⚠
- p.Gly509Ser Single submitter ⚠
- p.Gly538Ala Single submitter ⚠
- p.Gly545Glu Single submitter ⚠
- p.Gly547Ser Single submitter ⚠
- p.Gly552Arg Single submitter ⚠
- p.Gly73Ser Single submitter
- p.His398Gln Single submitter ⚠
- p.His62Gln Single submitter
- p.Ile440Phe Single submitter ⚠
- p.Leu539Val Single submitter ⚠
- p.Lys78Glu Single submitter ⚠
- p.Met285Val Single submitter ⚠
- p.Met513Thr Single submitter ⚠
- p.Phe144Cys Single submitter ⚠
- p.Pro128Leu Single submitter ⚠
- p.Pro174Ser Single submitter ⚠
- p.Pro19Arg Single submitter ⚠
- p.Pro205Ser Single submitter ⚠
- p.Pro235Ser Single submitter ⚠
- p.Pro322Leu Single submitter ⚠
- p.Pro359Leu Single submitter ⚠
- p.Pro361Thr Single submitter ⚠
- p.Pro391Thr Single submitter ⚠
- p.Pro423Ala Single submitter ⚠
- p.Pro457Ser Single submitter ⚠
- p.Pro540Leu Single submitter ⚠
- p.Pro553Arg Single submitter ⚠
- p.Ser490Arg Single submitter ⚠
- p.Thr104Ser Single submitter ⚠
- p.Thr150Met Single submitter ⚠
- p.Thr165Met Single submitter ⚠
- p.Thr25Met Single submitter ⚠
- p.Thr393Lys Single submitter ⚠
- p.Thr498Met Single submitter ⚠
- p.Thr543Ser Single submitter ⚠
- p.Thr77Ala Single submitter ⚠
- p.Trp270Cys Single submitter ⚠
- p.Val138Ala Single submitter ⚠
- p.Val199Met Single submitter ⚠
- p.Val277Met Single submitter
- p.Val296Met Single submitter
- p.Val313Met Single submitter ⚠
- p.Val481Ala Single submitter ⚠