ADGRA2 — 218 ClinVar variants

All ClinVar germline ADGRA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 207 flagged for review →

4 Benign · 7 Likely benign · 207 Uncertain significance

Full ADGRA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 207

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 113

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 94

The independent predictors disagree with each other — read with care.

All ADGRA2 variants

Benign 4

c.1608+5T>C Multiple submitters
p.Ala681Thr Multiple submitters ⚠
p.Arg671= Multiple submitters
p.Val1146Ala Single submitter

Likely benign 7

p.Ala34Ser Single submitter
p.Arg278His Single submitter
p.Arg280His Single submitter
p.Arg572Gln Single submitter
p.Arg799His Single submitter
p.Leu1131Pro Single submitter
p.Leu89= Single submitter

Uncertain significance 207

p.Ala1082Ser Single submitter ⚠
p.Ala1094Ser Single submitter ⚠
p.Ala1098Val Single submitter ⚠
p.Ala1102Thr Single submitter ⚠
p.Ala1102Val Single submitter ⚠
p.Ala1162Gly Single submitter ⚠
p.Ala1169Thr Single submitter ⚠
p.Ala1192Glu Single submitter ⚠
p.Ala11Glu Single submitter ⚠
p.Ala1209Thr Single submitter ⚠
p.Ala1260Thr Single submitter ⚠
p.Ala1266Val Single submitter ⚠
p.Ala1285Thr Single submitter ⚠
p.Ala1305Thr Single submitter ⚠
p.Ala219Val Single submitter ⚠
p.Ala294Gly Single submitter ⚠
p.Ala294Val Single submitter ⚠
p.Ala337Thr Single submitter ⚠
p.Ala394Asp Single submitter ⚠
p.Ala455Thr Single submitter ⚠
p.Ala525Pro Single submitter ⚠
p.Ala526Ser Single submitter ⚠
p.Ala526Thr Single submitter ⚠
p.Ala538Val Single submitter ⚠
p.Ala757Thr Single submitter ⚠
p.Ala857Val Single submitter ⚠
p.Ala891Ser Single submitter ⚠
p.Arg100Cys Single submitter ⚠
p.Arg1043Cys Single submitter ⚠
p.Arg1072Lys Single submitter ⚠
p.Arg1165Trp Single submitter ⚠
p.Arg116Thr Single submitter ⚠
p.Arg1200Pro Single submitter ⚠
p.Arg1205Leu Single submitter ⚠
p.Arg1235Cys Single submitter ⚠
p.Arg136His Single submitter ⚠
p.Arg143Gln Single submitter ⚠
p.Arg143Trp Single submitter ⚠
p.Arg14Ser Single submitter ⚠
p.Arg157Gly Single submitter ⚠
p.Arg160Gln Single submitter ⚠
p.Arg255His Single submitter ⚠
p.Arg357Leu Single submitter ⚠
p.Arg398Gln Single submitter ⚠
p.Arg401His Single submitter ⚠
p.Arg402Trp Single submitter ⚠
p.Arg405His Single submitter ⚠
p.Arg408Cys Single submitter ⚠
p.Arg408His Single submitter ⚠
p.Arg408Leu Single submitter ⚠
p.Arg448His Single submitter ⚠
p.Arg507His Single submitter ⚠
p.Arg514His Single submitter ⚠
p.Arg521His Single submitter ⚠
p.Arg564Lys Single submitter ⚠
p.Arg572Trp Single submitter ⚠
p.Arg593Cys Single submitter ⚠
p.Arg593His Single submitter ⚠
p.Arg600Lys Single submitter ⚠
p.Arg652Cys Single submitter ⚠
p.Arg662Cys Single submitter ⚠
p.Arg662Leu Single submitter ⚠
p.Arg671Lys Single submitter ⚠
p.Arg672His Single submitter ⚠
p.Arg700Trp Single submitter ⚠
p.Arg886Trp Single submitter ⚠
p.Arg964Ser Single submitter ⚠
p.Arg999Gln Single submitter ⚠
p.Arg9Leu Single submitter ⚠
p.Asn117Lys Single submitter ⚠
p.Asn602Ser Single submitter ⚠
p.Asn794Asp Single submitter ⚠
p.Asp1010Asn Single submitter ⚠
p.Asp262Asn Single submitter ⚠
p.Cys1050Arg Single submitter ⚠
p.Cys46Tyr Single submitter ⚠
p.Gln1271Glu Single submitter ⚠
p.Gln293Arg Single submitter ⚠
p.Gln832Arg Single submitter ⚠
p.Glu1158Lys Single submitter ⚠
p.Glu1265Ala Single submitter ⚠
p.Glu1265Lys Single submitter ⚠
p.Glu133Lys Single submitter ⚠
p.Glu150Ala Single submitter ⚠
p.Glu150Lys Single submitter ⚠
p.Glu234Asp Single submitter ⚠
p.Glu292Lys Single submitter ⚠
p.Glu30Gln Single submitter ⚠
p.Glu30Lys Single submitter ⚠
p.Glu583Lys Single submitter ⚠
p.Glu707Lys Single submitter ⚠
p.Glu727Lys Single submitter ⚠
p.Gly1016Arg Single submitter ⚠
p.Gly102Ser Single submitter ⚠
p.Gly10Glu Single submitter ⚠
p.Gly1106Cys Single submitter ⚠
p.Gly1123Arg Single submitter ⚠
p.Gly1123Ser Single submitter ⚠
p.Gly1163Asp Single submitter ⚠
p.Gly1207Asp Single submitter ⚠
p.Gly1267Ser Single submitter ⚠
p.Gly1283Ala Single submitter ⚠
p.Gly1309Asp Single submitter ⚠
p.Gly132Arg Single submitter ⚠
p.Gly1330Glu Single submitter ⚠
p.Gly319Cys Single submitter ⚠
p.Gly324Ser Single submitter ⚠
p.Gly412Glu Single submitter ⚠
p.Gly4Arg Single submitter ⚠
p.Gly523Ala Single submitter ⚠
p.Gly523Val Single submitter ⚠
p.Gly57Arg Single submitter ⚠
p.Gly599Arg Single submitter ⚠
p.Gly60Ser Single submitter ⚠
p.Gly689Glu Single submitter ⚠
p.Gly722Arg Single submitter ⚠
p.Gly722Glu Single submitter ⚠
p.Gly766Arg Single submitter ⚠
p.Gly768Glu Single submitter ⚠
p.Gly947Arg Single submitter ⚠
p.Gly947Trp Single submitter ⚠
p.Gly961Arg Single submitter ⚠
p.Gly961Asp Single submitter ⚠
p.Gly996Val Single submitter ⚠
p.His1291Arg Single submitter ⚠
p.His742Gln Single submitter ⚠
p.His745Arg Single submitter ⚠
p.Ile522Thr Single submitter ⚠
p.Ile792Ser Single submitter ⚠
p.Leu1030Phe Single submitter ⚠
p.Leu1244Pro Single submitter ⚠
p.Leu1286Pro Single submitter ⚠
p.Leu217Phe Single submitter ⚠
p.Leu547His Single submitter ⚠
p.Leu752Phe Single submitter ⚠
p.Leu82Met Single submitter ⚠
p.Leu851Phe Single submitter ⚠
p.Leu889Phe Single submitter ⚠
p.Leu90His Single submitter ⚠
p.Lys1202Glu Single submitter ⚠
p.Lys1333Asn Single submitter ⚠
p.Met1249Leu Single submitter ⚠
p.Met461Thr Single submitter ⚠
p.Met487Thr Single submitter ⚠
p.Met817Ile Single submitter ⚠
p.Met8Thr Single submitter ⚠
p.Phe430Leu Single submitter ⚠
p.Phe785Leu Single submitter ⚠
p.Pro1015Leu Single submitter ⚠
p.Pro1086Thr Single submitter ⚠
p.Pro1096Leu Single submitter ⚠
p.Pro1108Leu Single submitter ⚠
p.Pro1114Ala Single submitter ⚠
p.Pro1159Leu Single submitter ⚠
p.Pro125Arg Single submitter ⚠
p.Pro1306Ala Single submitter ⚠
p.Pro21Arg Single submitter ⚠
p.Pro252Gln Single submitter ⚠
p.Pro29Leu Single submitter ⚠
p.Pro35Ser Single submitter ⚠
p.Pro389Thr Single submitter ⚠
p.Pro395Leu Single submitter ⚠
p.Pro395Ser Single submitter ⚠
p.Pro569Leu Single submitter ⚠
p.Pro581Gln Single submitter ⚠
p.Pro581Leu Single submitter ⚠
p.Pro635Ser Single submitter ⚠
p.Pro74Leu Single submitter ⚠
p.Pro870Thr Single submitter ⚠
p.Pro883Arg Single submitter ⚠
p.Pro895Ser Single submitter ⚠
p.Pro915Ala Single submitter ⚠
p.Pro953Leu Single submitter ⚠
p.Ser1276Gly Single submitter ⚠
p.Ser456Cys Single submitter ⚠
p.Ser627Leu Single submitter ⚠
p.Ser726Leu Single submitter ⚠
p.Ser756Gly Single submitter ⚠
p.Ser845Tyr Single submitter ⚠
p.Thr1002Met Single submitter ⚠
p.Thr1024Ser Single submitter ⚠
p.Thr193Ile Single submitter ⚠
p.Thr216Met Single submitter ⚠
p.Thr314Met Single submitter ⚠
p.Thr660Ser Single submitter ⚠
p.Thr777Met Single submitter ⚠
p.Thr849Met Single submitter ⚠
p.Thr97Ala Single submitter ⚠
p.Thr995Ser Single submitter ⚠
p.Trp281Arg Single submitter ⚠
p.Trp281Cys Single submitter ⚠
p.Trp702Arg Single submitter ⚠
p.Trp918Cys Single submitter ⚠
p.Tyr1013Ser Single submitter ⚠
p.Tyr450Phe Single submitter ⚠
p.Val1023Leu Single submitter ⚠
p.Val1049Glu Single submitter ⚠
p.Val320Leu Single submitter ⚠
p.Val431Met Single submitter ⚠
p.Val516Met Single submitter ⚠
p.Val536Gly Single submitter ⚠
p.Val834Ile Single submitter ⚠
p.Val855Met Single submitter ⚠
p.Val87Ala Single submitter ⚠
p.Val920Met Single submitter ⚠
p.Ala868Val No assertion criteria ⚠
p.Asn439fs No assertion criteria ependymoma