Sugi Variant

Sugi Variant/ADGRB2

ADGRB2 — 447 ClinVar variants

All ClinVar germline ADGRB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 222 flagged for review →

1 Likely pathogenic · 3 Conflicting · 43 Benign · 125 Likely benign · 275 Uncertain significance

Full ADGRB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 222

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 169

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 169

Predictors split 49

The independent predictors disagree with each other — read with care.

All ADGRB2 variants

Likely pathogenic 1

Conflicting classifications of pathogenicity 3

Benign 43

Likely benign 125

Uncertain significance 275