ADGRB3 — 161 ClinVar variants
All ClinVar germline ADGRB3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 143 flagged for review →
2 Likely pathogenic · 2 Likely benign · 157 Uncertain significance
Full ADGRB3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 143
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 110
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADGRB3 p.Ala1086Thr Uncertain significance Single submitter
- ADGRB3 p.Ala429Glu Uncertain significance Single submitter
- ADGRB3 p.Ala442Thr Uncertain significance Single submitter
- ADGRB3 p.Ala764Thr Uncertain significance Single submitter
- ADGRB3 p.Ala891Ser Uncertain significance Single submitter
- ADGRB3 p.Arg1159Lys Uncertain significance Single submitter
- ADGRB3 p.Arg1161Gln Uncertain significance Single submitter
- ADGRB3 p.Arg132Gln Uncertain significance Single submitter
- ADGRB3 p.Arg274Thr Uncertain significance Single submitter
- ADGRB3 p.Arg500Lys Uncertain significance Single submitter
- ADGRB3 p.Arg548Cys Uncertain significance Single submitter
- ADGRB3 p.Asn1346Lys Uncertain significance Single submitter
- ADGRB3 p.Asn1350Ser Uncertain significance Single submitter
- ADGRB3 p.Asn1360Ser Uncertain significance Single submitter
- ADGRB3 p.Asn1486Asp Uncertain significance Single submitter
- ADGRB3 p.Asn82Lys Uncertain significance Single submitter
- ADGRB3 p.Asp100Glu Uncertain significance Single submitter
- ADGRB3 p.Asp100Tyr Uncertain significance Single submitter
- ADGRB3 p.Asp1286Glu Uncertain significance Single submitter
- ADGRB3 p.Asp1286Gly Uncertain significance Single submitter
- ADGRB3 p.Asp1287Asn Uncertain significance Single submitter
- ADGRB3 p.Asp1453Glu Uncertain significance Single submitter
- ADGRB3 p.Asp1494Val Uncertain significance Single submitter
- ADGRB3 p.Asp1512Asn Uncertain significance Single submitter
- ADGRB3 p.Asp208Gly Uncertain significance Single submitter
- ADGRB3 p.Asp531Asn Uncertain significance Single submitter
- ADGRB3 p.Asp640Asn Uncertain significance Single submitter
- ADGRB3 p.Asp77Asn Uncertain significance Single submitter
- ADGRB3 p.Gln402Leu Uncertain significance Single submitter
- ADGRB3 p.Gln561His Uncertain significance Single submitter
- ADGRB3 p.Gln597Arg Uncertain significance Single submitter
- ADGRB3 p.Gln865Arg Uncertain significance Single submitter
- ADGRB3 p.Glu1264Gln Uncertain significance Single submitter
- ADGRB3 p.Glu147Ala Uncertain significance Single submitter
- ADGRB3 p.Glu204Gln Uncertain significance Single submitter
- ADGRB3 p.Glu224Lys Uncertain significance Single submitter
- ADGRB3 p.Glu581Asp Uncertain significance Single submitter
- ADGRB3 p.Glu659Lys Uncertain significance Single submitter
- ADGRB3 p.Glu829Lys Uncertain significance Single submitter
- ADGRB3 p.Gly1063Ser Uncertain significance Single submitter
- ADGRB3 p.Gly328Ser Uncertain significance Single submitter
- ADGRB3 p.Gly594Arg Uncertain significance Single submitter
- ADGRB3 p.His1011Gln Uncertain significance Single submitter
- ADGRB3 p.His1060Gln Uncertain significance Single submitter
- ADGRB3 p.His1060Leu Uncertain significance Single submitter
- ADGRB3 p.His1298Tyr Uncertain significance Single submitter
- ADGRB3 p.His201Arg Uncertain significance Single submitter
- ADGRB3 p.His574Arg Uncertain significance Single submitter
- ADGRB3 p.His683Tyr Uncertain significance Single submitter
- ADGRB3 p.Ile479Leu Uncertain significance Single submitter
- ADGRB3 p.Ile667Val Uncertain significance Single submitter
- ADGRB3 p.Ile672Val Uncertain significance Single submitter
- ADGRB3 p.Ile684Val Uncertain significance Single submitter
- ADGRB3 p.Ile718Asn Uncertain significance Single submitter
- ADGRB3 p.Ile718Val Uncertain significance Single submitter
- ADGRB3 p.Ile792Val Uncertain significance Single submitter
- ADGRB3 p.Ile805Val Uncertain significance Single submitter
- ADGRB3 p.Ile870Thr Uncertain significance Single submitter
- ADGRB3 p.Leu1376Phe Uncertain significance Single submitter
- ADGRB3 p.Leu396Val Uncertain significance Single submitter
- ADGRB3 p.Leu553Val Uncertain significance Single submitter
- ADGRB3 p.Leu652Val Uncertain significance Single submitter
- ADGRB3 p.Leu777Phe Uncertain significance Single submitter
- ADGRB3 p.Leu78Phe Uncertain significance Single submitter
- ADGRB3 p.Leu85Phe Uncertain significance Single submitter
- ADGRB3 p.Lys115Asn Uncertain significance Single submitter
- ADGRB3 p.Lys1385Arg Uncertain significance Single submitter
- ADGRB3 p.Lys658Arg Uncertain significance Single submitter
- ADGRB3 p.Lys658Glu Uncertain significance Single submitter
- ADGRB3 p.Lys786Arg Uncertain significance Single submitter
- ADGRB3 p.Lys99Glu Uncertain significance Single submitter
- ADGRB3 p.Met1065Val Uncertain significance Single submitter
- ADGRB3 p.Met1328Val Uncertain significance Single submitter
- ADGRB3 p.Met1388Thr Uncertain significance Single submitter
- ADGRB3 p.Met192Val Uncertain significance Single submitter
- ADGRB3 p.Met618Val Uncertain significance Single submitter
- ADGRB3 p.Phe1128Ser Uncertain significance Single submitter
- ADGRB3 p.Phe534Val Uncertain significance Single submitter
- ADGRB3 p.Phe720Leu Uncertain significance Single submitter
- ADGRB3 p.Phe802Leu Uncertain significance Single submitter
- ADGRB3 p.Pro1068Thr Uncertain significance Single submitter
- ADGRB3 p.Pro1232Leu Uncertain significance Single submitter
- ADGRB3 p.Pro1232Thr Uncertain significance Single submitter
- ADGRB3 p.Pro1480Leu Uncertain significance Single submitter
- ADGRB3 p.Pro199Leu Uncertain significance Single submitter
- ADGRB3 p.Pro250Ser Uncertain significance Single submitter
- ADGRB3 p.Pro510Thr Uncertain significance Single submitter
- ADGRB3 p.Pro742Thr Uncertain significance Single submitter
- ADGRB3 p.Ser151Cys Uncertain significance Single submitter
- ADGRB3 p.Ser151Tyr Uncertain significance Single submitter
- ADGRB3 p.Ser211Trp Uncertain significance Single submitter
- ADGRB3 p.Ser470Thr Uncertain significance Single submitter
- ADGRB3 p.Thr1073Met Uncertain significance Single submitter
- ADGRB3 p.Thr1490Ala Uncertain significance Single submitter
- ADGRB3 p.Thr173Ala Uncertain significance Single submitter
- ADGRB3 p.Thr237Ile Uncertain significance Single submitter
- ADGRB3 p.Thr261Ala Uncertain significance Single submitter
- ADGRB3 p.Thr369Ser Uncertain significance Single submitter
- ADGRB3 p.Thr428Pro Uncertain significance Single submitter
- ADGRB3 p.Thr495Met Uncertain significance Single submitter
- ADGRB3 p.Thr601Ile Uncertain significance Single submitter
- ADGRB3 p.Trp29Leu Uncertain significance Single submitter
- ADGRB3 p.Trp354Arg Uncertain significance Single submitter
- ADGRB3 p.Tyr612Cys Uncertain significance Single submitter
- ADGRB3 p.Val1081Ile Uncertain significance Single submitter
- ADGRB3 p.Val1345Leu Uncertain significance Single submitter
- ADGRB3 p.Val218Ala Uncertain significance Single submitter
- ADGRB3 p.Val294Met Uncertain significance Single submitter
- ADGRB3 p.Val789Met Uncertain significance Single submitter
- ADGRB3 p.Val820Ala Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- ADGRB3 p.Arg1151Gln Uncertain significance Single submitter
- ADGRB3 p.Arg1381Cys Uncertain significance Single submitter
- ADGRB3 p.Arg1414Thr Uncertain significance Single submitter
- ADGRB3 p.Arg334Ser Uncertain significance Single submitter
- ADGRB3 p.Arg738Gly Uncertain significance Single submitter
- ADGRB3 p.Asn651Lys Uncertain significance Single submitter
- ADGRB3 p.Asp1156Gly Uncertain significance Single submitter
- ADGRB3 p.Asp124Gly Uncertain significance Single submitter
- ADGRB3 p.Asp1421Glu Uncertain significance Single submitter
- ADGRB3 p.Asp27Val Uncertain significance Single submitter
- ADGRB3 p.Cys189Arg Uncertain significance Single submitter
- ADGRB3 p.Cys229Arg Uncertain significance Single submitter
- ADGRB3 p.Cys240Phe Uncertain significance Single submitter
- ADGRB3 p.Glu272Val Uncertain significance Single submitter
- ADGRB3 p.Glu571Val Uncertain significance Single submitter
- ADGRB3 p.Gly724Arg Uncertain significance Single submitter
- ADGRB3 p.Gly838Glu Uncertain significance Single submitter
- ADGRB3 p.Leu1127Met Uncertain significance Single submitter
- ADGRB3 p.Lys1056Glu Uncertain significance Single submitter
- ADGRB3 p.Lys1078Glu Uncertain significance Single submitter
- ADGRB3 p.Lys97Asn Uncertain significance Single submitter
- ADGRB3 p.Phe1473Leu Uncertain significance Single submitter
- ADGRB3 p.Phe558Leu Uncertain significance Single submitter
- ADGRB3 p.Pro1241Ser Uncertain significance Single submitter
- ADGRB3 p.Pro775Ala Uncertain significance Single submitter
- ADGRB3 p.Ser435Pro Uncertain significance Single submitter
- ADGRB3 p.Ser650Asn Uncertain significance Single submitter
- ADGRB3 p.Thr56Ile Uncertain significance Single submitter
- ADGRB3 p.Tyr696Cys Uncertain significance Single submitter
- ADGRB3 p.Tyr696His Uncertain significance Single submitter
- ADGRB3 p.Val761Phe Uncertain significance Single submitter
-
ADGRB3 p.Arg1433Lys
Likely pathogenic
No assertion criteria
Short stature
-
ADGRB3 p.Val765Ala
Likely pathogenic
No assertion criteria
Short stature
All ADGRB3 variants
Likely pathogenic 2
- p.Arg1433Lys No assertion criteria Short stature ⚠
- p.Val765Ala No assertion criteria Short stature ⚠
Likely benign 2
- p.Ala1116= Single submitter
- p.Thr136Ser Single submitter
Uncertain significance 157
- p.Ala1086Thr Single submitter ⚠
- p.Ala429Glu Single submitter ⚠
- p.Ala442Thr Single submitter ⚠
- p.Ala764Thr Single submitter ⚠
- p.Ala891Ser Single submitter ⚠
- p.Ala946Val Single submitter
- p.Arg1151Gln Single submitter ⚠
- p.Arg1159Lys Single submitter ⚠
- p.Arg1161Gln Single submitter ⚠
- p.Arg131His Single submitter
- p.Arg132Gln Single submitter ⚠
- p.Arg1381Cys Single submitter ⚠
- p.Arg1414Thr Single submitter ⚠
- p.Arg1452Trp Single submitter
- p.Arg274Thr Single submitter ⚠
- p.Arg334Ser Single submitter ⚠
- p.Arg500Lys Single submitter ⚠
- p.Arg548Cys Single submitter ⚠
- p.Arg738Gly Single submitter ⚠
- p.Arg977Gln Single submitter
- p.Asn1346Lys Single submitter ⚠
- p.Asn1350Ser Single submitter ⚠
- p.Asn1360Ser Single submitter ⚠
- p.Asn1486Asp Single submitter ⚠
- p.Asn651Lys Single submitter ⚠
- p.Asn82Lys Single submitter ⚠
- p.Asp100Glu Single submitter ⚠
- p.Asp100Tyr Single submitter ⚠
- p.Asp1156Gly Single submitter ⚠
- p.Asp124Gly Single submitter ⚠
- p.Asp1286Glu Single submitter ⚠
- p.Asp1286Gly Single submitter ⚠
- p.Asp1287Asn Single submitter ⚠
- p.Asp1421Glu Single submitter ⚠
- p.Asp1453Glu Single submitter ⚠
- p.Asp1494Val Single submitter ⚠
- p.Asp1512Asn Single submitter ⚠
- p.Asp208Gly Single submitter ⚠
- p.Asp27Val Single submitter ⚠
- p.Asp531Asn Single submitter ⚠
- p.Asp640Asn Single submitter ⚠
- p.Asp77Asn Single submitter ⚠
- p.Cys189Arg Single submitter ⚠
- p.Cys229Arg Single submitter ⚠
- p.Cys240Phe Single submitter ⚠
- p.Gln402Leu Single submitter ⚠
- p.Gln483fs Single submitter
- p.Gln561His Single submitter ⚠
- p.Gln597Arg Single submitter ⚠
- p.Gln865Arg Single submitter ⚠
- p.Glu1264Gln Single submitter ⚠
- p.Glu147Ala Single submitter ⚠
- p.Glu204Gln Single submitter ⚠
- p.Glu224Lys Single submitter ⚠
- p.Glu272Val Single submitter ⚠
- p.Glu497Lys Single submitter
- p.Glu571Val Single submitter ⚠
- p.Glu581Asp Single submitter ⚠
- p.Glu659Lys Single submitter ⚠
- p.Glu829Lys Single submitter ⚠
- p.Gly1063Ser Single submitter ⚠
- p.Gly328Ser Single submitter ⚠
- p.Gly594Arg Single submitter ⚠
- p.Gly724Arg Single submitter ⚠
- p.Gly838Glu Single submitter ⚠
- p.His1011Gln Single submitter ⚠
- p.His1060Gln Single submitter ⚠
- p.His1060Leu Single submitter ⚠
- p.His1298Tyr Single submitter ⚠
- p.His201Arg Single submitter ⚠
- p.His574Arg Single submitter ⚠
- p.His683Tyr Single submitter ⚠
- p.His848Arg Single submitter
- p.Ile479Leu Single submitter ⚠
- p.Ile667Val Single submitter ⚠
- p.Ile672Val Single submitter ⚠
- p.Ile684Val Single submitter ⚠
- p.Ile718Asn Single submitter ⚠
- p.Ile718Val Single submitter ⚠
- p.Ile792Val Single submitter ⚠
- p.Ile805Val Single submitter ⚠
- p.Ile870Thr Single submitter ⚠
- p.Leu1127Met Single submitter ⚠
- p.Leu1376Phe Single submitter ⚠
- p.Leu202Ser Single submitter
- p.Leu33Phe Single submitter
- p.Leu396Val Single submitter ⚠
- p.Leu553Val Single submitter ⚠
- p.Leu652Val Single submitter ⚠
- p.Leu777Phe Single submitter ⚠
- p.Leu78Phe Single submitter ⚠
- p.Leu85Phe Single submitter ⚠
- p.Lys1056Glu Single submitter ⚠
- p.Lys1078Glu Single submitter ⚠
- p.Lys115Asn Single submitter ⚠
- p.Lys1385Arg Single submitter ⚠
- p.Lys658Arg Single submitter ⚠
- p.Lys658Glu Single submitter ⚠
- p.Lys786Arg Single submitter ⚠
- p.Lys97Asn Single submitter ⚠
- p.Lys99Glu Single submitter ⚠
- p.Met1065Val Single submitter ⚠
- p.Met1328Val Single submitter ⚠
- p.Met1388Thr Single submitter ⚠
- p.Met1435Thr Single submitter
- p.Met192Val Single submitter ⚠
- p.Met47fs Single submitter
- p.Met618Val Single submitter ⚠
- p.Phe1128Ser Single submitter ⚠
- p.Phe1473Leu Single submitter ⚠
- p.Phe534Val Single submitter ⚠
- p.Phe558Leu Single submitter ⚠
- p.Phe720Leu Single submitter ⚠
- p.Phe802Leu Single submitter ⚠
- p.Pro1068Thr Single submitter ⚠
- p.Pro1232Leu Single submitter ⚠
- p.Pro1232Thr Single submitter ⚠
- p.Pro1241Ser Single submitter ⚠
- p.Pro1480Leu Single submitter ⚠
- p.Pro199Leu Single submitter ⚠
- p.Pro250Ser Single submitter ⚠
- p.Pro510Thr Single submitter ⚠
- p.Pro742Thr Single submitter ⚠
- p.Pro775Ala Single submitter ⚠
- p.Ser151Cys Single submitter ⚠
- p.Ser151Tyr Single submitter ⚠
- p.Ser211Trp Single submitter ⚠
- p.Ser435Pro Single submitter ⚠
- p.Ser470Thr Single submitter ⚠
- p.Ser650Asn Single submitter ⚠
- p.Thr1073Met Single submitter ⚠
- p.Thr1490Ala Single submitter ⚠
- p.Thr173Ala Single submitter ⚠
- p.Thr226Arg Single submitter
- p.Thr237Ile Single submitter ⚠
- p.Thr261Ala Single submitter ⚠
- p.Thr32Ile Single submitter
- p.Thr369Ser Single submitter ⚠
- p.Thr428Pro Single submitter ⚠
- p.Thr495Met Single submitter ⚠
- p.Thr56Ile Single submitter ⚠
- p.Thr601Ile Single submitter ⚠
- p.Thr858Asn Single submitter
- p.Trp29Leu Single submitter ⚠
- p.Trp354Arg Single submitter ⚠
- p.Tyr612Cys Single submitter ⚠
- p.Tyr696Cys Single submitter ⚠
- p.Tyr696His Single submitter ⚠
- p.Val1081Ile Single submitter ⚠
- p.Val1345Leu Single submitter ⚠
- p.Val218Ala Single submitter ⚠
- p.Val294Met Single submitter ⚠
- p.Val714Phe Single submitter
- p.Val729Phe Single submitter
- p.Val761Phe Single submitter ⚠
- p.Val789Met Single submitter ⚠
- p.Val820Ala Single submitter ⚠