ADGRF1 — 145 ClinVar variants

All ClinVar germline ADGRF1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 130 flagged for review →

1 Benign · 1 Benign/Likely benign · 15 Likely benign · 128 Uncertain significance

Full ADGRF1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 130

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 108

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 22

The independent predictors disagree with each other — read with care.

All ADGRF1 variants

Benign 1

p.Ser96Arg Single submitter

Benign/Likely benign 1

p.Thr803Pro Multiple submitters ⚠

Likely benign 15

p.Arg161Lys Single submitter
p.Arg473Lys Single submitter
p.Arg780Gln Single submitter
p.Asp546Asn Single submitter
p.Asp899Asn Single submitter
p.Gly444Asp Single submitter ⚠
p.Ile595Val Single submitter
p.Ser386Leu Single submitter
p.Thr201Ile Single submitter
p.Thr560Met Single submitter
p.Thr658Ile Single submitter
p.Val209Ile Single submitter
p.Val342Ala Single submitter
p.Val493Ile Single submitter
p.Val789Met Single submitter

Uncertain significance 128

p.Ala178Val Single submitter ⚠
p.Ala378Val Single submitter ⚠
p.Ala784Thr Single submitter ⚠
p.Arg161Ser Single submitter ⚠
p.Arg395Trp Single submitter ⚠
p.Arg403Leu Single submitter ⚠
p.Arg403Pro Single submitter ⚠
p.Arg403Trp Single submitter ⚠
p.Arg623Cys Single submitter ⚠
p.Arg624Cys Single submitter ⚠
p.Arg624Leu Single submitter ⚠
p.Arg63Gly Single submitter ⚠
p.Arg63Lys Single submitter ⚠
p.Arg729Ser Single submitter ⚠
p.Arg780Trp Single submitter ⚠
p.Arg846Gln Single submitter ⚠
p.Arg846Leu Single submitter ⚠
p.Asn205Lys Single submitter ⚠
p.Asn37Tyr Single submitter ⚠
p.Asn502Ser Single submitter ⚠
p.Asn553Ser Single submitter ⚠
p.Asn881Lys Single submitter ⚠
p.Asp26Gly Single submitter ⚠
p.Asp648His Single submitter ⚠
p.Asp813His Single submitter ⚠
p.Cys257Ser Single submitter ⚠
p.Cys549Tyr Single submitter ⚠
p.Cys603Arg Single submitter ⚠
p.Cys603Trp Single submitter ⚠
p.Cys94Tyr Single submitter ⚠
p.Gln500Arg Single submitter ⚠
p.Gln53His Single submitter ⚠
p.Glu270Val Single submitter ⚠
p.Glu33Val Single submitter ⚠
p.Glu406Lys Single submitter ⚠
p.Glu46Lys Single submitter ⚠
p.Glu554Asp Single submitter ⚠
p.Glu607Lys Single submitter ⚠
p.Glu776Gly Single submitter ⚠
p.Gly19Ser Single submitter ⚠
p.Gly206Glu Single submitter ⚠
p.Gly488Glu Single submitter ⚠
p.Gly594Asp Single submitter ⚠
p.Gly775Glu Single submitter ⚠
p.Gly895Ala Single submitter ⚠
p.His229Pro Single submitter ⚠
p.His41Arg Single submitter ⚠
p.His41Tyr Single submitter ⚠
p.His550Tyr Single submitter ⚠
p.Ile227Thr Single submitter ⚠
p.Ile35Asn Single submitter ⚠
p.Ile434Asn Single submitter ⚠
p.Ile449Asn Single submitter ⚠
p.Ile510Phe Single submitter ⚠
p.Ile515Val Single submitter ⚠
p.Ile642Thr Single submitter ⚠
p.Ile712Val Single submitter ⚠
p.Ile754Thr Single submitter ⚠
p.Ile787Thr Single submitter ⚠
p.Ile811Thr Single submitter ⚠
p.Ile901Val Single submitter ⚠
p.Leu124Ile Single submitter ⚠
p.Leu572Ser Single submitter ⚠
p.Leu745Val Single submitter ⚠
p.Leu752Met Single submitter ⚠
p.Leu802Pro Single submitter ⚠
p.Lys240Arg Single submitter ⚠
p.Lys309Thr Single submitter ⚠
p.Lys612Glu Single submitter ⚠
p.Met371Val Single submitter ⚠
p.Met573Ile Single submitter ⚠
p.Met677Val Single submitter ⚠
p.Met693Val Single submitter ⚠
p.Met699Thr Single submitter ⚠
p.Phe14Leu Single submitter ⚠
p.Phe242Leu Single submitter ⚠
p.Phe252Leu Single submitter ⚠
p.Phe576Ile Single submitter ⚠
p.Phe576Leu Single submitter ⚠
p.Phe662Leu Single submitter ⚠
p.Phe829Ser Single submitter ⚠
p.Pro119Ala Single submitter ⚠
p.Pro243Ala Single submitter ⚠
p.Pro274Leu Single submitter ⚠
p.Pro338Leu Single submitter ⚠
p.Pro338Thr Single submitter ⚠
p.Pro416Leu Single submitter ⚠
p.Pro417Leu Single submitter ⚠
p.Pro575Arg Single submitter ⚠
p.Ser197Leu Single submitter ⚠
p.Ser219Gly Single submitter ⚠
p.Ser277Arg Single submitter ⚠
p.Ser401Gly Single submitter ⚠
p.Ser439Asn Single submitter ⚠
p.Ser446Gly Single submitter ⚠
p.Ser530Asn Single submitter ⚠
p.Ser620Thr Single submitter ⚠
p.Ser714Ala Single submitter ⚠
p.Ser714Phe Single submitter ⚠
p.Ser898Thr Single submitter ⚠
p.Thr110Ile Single submitter ⚠
p.Thr284Ile Single submitter ⚠
p.Thr341Ala Single submitter ⚠
p.Thr370Lys Single submitter ⚠
p.Thr391Arg Single submitter ⚠
p.Thr560Lys Single submitter ⚠
p.Thr619Ile Single submitter ⚠
p.Thr721Met Single submitter ⚠
p.Thr810Ile Single submitter ⚠
p.Trp544Arg Single submitter ⚠
p.Trp859Arg Single submitter ⚠
p.Tyr123Cys Single submitter ⚠
p.Tyr279Cys Single submitter ⚠
p.Val144Ala Single submitter ⚠
p.Val144Phe Single submitter ⚠
p.Val214Phe Single submitter ⚠
p.Val327Met Single submitter ⚠
p.Val366Ala Single submitter ⚠
p.Val415Gly Single submitter ⚠
p.Val415Met Single submitter ⚠
p.Val436Met Single submitter ⚠
p.Val45Phe Single submitter ⚠
p.Val493Phe Single submitter ⚠
p.Val559Met Single submitter ⚠
p.Val647Met Single submitter ⚠
p.Val689Leu Single submitter ⚠
p.Val761Ala Single submitter ⚠
p.Val774Ile Single submitter ⚠