ADGRF3 — 186 ClinVar variants

All ClinVar germline ADGRF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 162 flagged for review →

1 Conflicting · 1 Benign · 18 Likely benign · 166 Uncertain significance

Full ADGRF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 162

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

ADGRF3 p.Val832Ile Conflicting Single submitter

Predictors lean, ClinVar uncertain 126

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 35

The independent predictors disagree with each other — read with care.

All ADGRF3 variants

Conflicting classifications of pathogenicity 1

p.Val832Ile Single submitter ⚠

Benign 1

p.Arg769Ter Single submitter

Likely benign 18

p.Ala300Val Single submitter
p.Ala367Thr Single submitter
p.Ala534Thr Single submitter
p.Ala701Thr Single submitter
p.Ala777Thr Single submitter
p.Arg327His Single submitter
p.Arg498= Single submitter
p.Arg498Ser Single submitter
p.Arg562Gln Single submitter
p.Arg579His Single submitter
p.Arg969His Single submitter
p.Asn57Ser Single submitter
p.Gly305Arg Single submitter
p.Leu565= Single submitter
p.Ser311Phe Single submitter
p.Ser630Asn Single submitter
p.Val231Ile Single submitter
p.Val406Ile Single submitter

Uncertain significance 166

c.115-1315G>A Single submitter ⚠
c.115-1349C>A Single submitter ⚠
c.115-1360G>A Single submitter ⚠
c.115-1415G>A Single submitter ⚠
c.115-1448A>G Single submitter ⚠
c.115-1453C>T Single submitter ⚠
c.115-1477C>T Single submitter ⚠
c.115-1480G>A Single submitter ⚠
c.115-477C>T Single submitter ⚠
c.115-484C>A Single submitter ⚠
c.115-511T>C Single submitter ⚠
c.115-537T>C Single submitter ⚠
c.115-541C>G Single submitter ⚠
c.115-541C>T Single submitter ⚠
c.115-553T>G Single submitter ⚠
c.115-556C>A Single submitter ⚠
c.2937+5G>A Single submitter ⚠
c.2937+64C>T Single submitter ⚠
c.2937+80T>C Single submitter ⚠
c.500-4G>A Single submitter ⚠
p.Ala227Val Single submitter ⚠
p.Ala265Glu Single submitter ⚠
p.Ala377Pro Single submitter
p.Ala448Thr Single submitter ⚠
p.Ala481Gly Single submitter ⚠
p.Ala504Thr Single submitter ⚠
p.Ala567Ser Single submitter ⚠
p.Ala701Val Single submitter ⚠
p.Ala703Val Single submitter ⚠
p.Ala777Asp Single submitter ⚠
p.Ala777Val Single submitter ⚠
p.Ala786Val Single submitter
p.Ala877Thr Single submitter ⚠
p.Ala879Thr Single submitter ⚠
p.Ala894Thr Single submitter ⚠
p.Arg270Gln Single submitter ⚠
p.Arg327Cys Single submitter ⚠
p.Arg479His Single submitter ⚠
p.Arg507Trp Single submitter ⚠
p.Arg562Trp Single submitter ⚠
p.Arg658Ser Single submitter ⚠
p.Arg733Gln Single submitter ⚠
p.Arg813Gln Single submitter ⚠
p.Arg813Pro Single submitter ⚠
p.Arg964Cys Single submitter ⚠
p.Arg966Cys Single submitter ⚠
p.Arg966Pro Single submitter ⚠
p.Asn111Ser Single submitter ⚠
p.Asn144Asp Single submitter ⚠
p.Asn373His Single submitter ⚠
p.Asn539Ser Single submitter ⚠
p.Asn601Ile Single submitter ⚠
p.Asn746Ile Single submitter ⚠
p.Asp182Ala Single submitter ⚠
p.Asp455Asn Single submitter ⚠
p.Asp494His Single submitter ⚠
p.Asp637His Single submitter ⚠
p.Asp642Val Single submitter ⚠
p.Cys279Tyr Single submitter ⚠
p.Cys320Arg Single submitter ⚠
p.Cys328Ser Single submitter ⚠
p.Cys773Ter Single submitter
p.Cys968Tyr Single submitter ⚠
p.Gln249Arg Single submitter ⚠
p.Gln357Arg Single submitter ⚠
p.Gln357His Single submitter ⚠
p.Gln426His Single submitter ⚠
p.Gln631Arg Single submitter ⚠
p.Glu157Lys Single submitter ⚠
p.Glu193Lys Single submitter ⚠
p.Glu315Gln Single submitter ⚠
p.Glu583Lys Single submitter ⚠
p.Glu846Lys Single submitter ⚠
p.Gly169Arg Single submitter ⚠
p.Gly225Asp Single submitter ⚠
p.Gly48Val Single submitter ⚠
p.Gly50Glu Single submitter ⚠
p.Gly643Asp Single submitter ⚠
p.Gly660Cys Single submitter ⚠
p.Gly711Glu Single submitter ⚠
p.Gly767Glu Single submitter ⚠
p.Gly863Arg Single submitter ⚠
p.His224Arg Single submitter ⚠
p.His934Arg Single submitter ⚠
p.Ile132Asn Single submitter ⚠
p.Ile277Thr Single submitter ⚠
p.Ile361Asn Single submitter ⚠
p.Ile487Phe Single submitter ⚠
p.Ile557Leu Single submitter ⚠
p.Ile936Val Single submitter ⚠
p.Ile977Asn Single submitter ⚠
p.Ile977Thr Single submitter ⚠
p.Leu171Phe Single submitter ⚠
p.Leu229Phe Single submitter ⚠
p.Leu415Ile Single submitter ⚠
p.Leu517Met Single submitter ⚠
p.Leu606Arg Single submitter ⚠
p.Leu610Phe Single submitter ⚠
p.Leu618Phe Single submitter ⚠
p.Leu690Pro Single submitter ⚠
p.Leu764His Single submitter ⚠
p.Leu783Ile Single submitter ⚠
p.Leu803Phe Single submitter ⚠
p.Leu836Val Single submitter ⚠
p.Leu851Val Single submitter
p.Leu88Arg Single submitter ⚠
p.Leu907Met Single submitter ⚠
p.Met636Val Single submitter ⚠
p.Met691Val Single submitter ⚠
p.Phe118Val Single submitter ⚠
p.Phe739Tyr Single submitter ⚠
p.Phe789Leu Single submitter ⚠
p.Phe789Val Single submitter ⚠
p.Pro156Ser Single submitter ⚠
p.Pro207Leu Single submitter ⚠
p.Pro292Thr Single submitter ⚠
p.Pro329Leu Single submitter ⚠
p.Pro405Leu Single submitter ⚠
p.Pro549Arg Single submitter ⚠
p.Pro552Leu Single submitter ⚠
p.Pro675Arg Single submitter ⚠
p.Pro693Leu Single submitter ⚠
p.Pro700Leu Single submitter ⚠
p.Pro892Ala Single submitter ⚠
p.Pro893Ser Single submitter ⚠
p.Ser175Cys Single submitter ⚠
p.Ser175Phe Single submitter ⚠
p.Ser198Cys Single submitter ⚠
p.Ser288Asn Single submitter ⚠
p.Ser368Leu Single submitter ⚠
p.Thr183Met Single submitter ⚠
p.Thr299Ile Single submitter ⚠
p.Thr334Ala Single submitter ⚠
p.Thr334Lys Single submitter ⚠
p.Thr334Met Single submitter ⚠
p.Thr354Ala Single submitter ⚠
p.Thr362Asn Single submitter ⚠
p.Thr502Ile Single submitter ⚠
p.Thr521Asn Single submitter ⚠
p.Thr550Met Single submitter ⚠
p.Thr756Ala Single submitter ⚠
p.Thr787Ile Single submitter ⚠
p.Thr931Met Single submitter ⚠
p.Trp238Ter Single submitter
p.Trp725Cys Single submitter ⚠
p.Trp850Cys Single submitter ⚠
p.Tyr335Cys Single submitter ⚠
p.Tyr555Cys Single submitter ⚠
p.Val112Ala Single submitter ⚠
p.Val231Ala Single submitter ⚠
p.Val258Met Single submitter ⚠
p.Val406Leu Single submitter ⚠
p.Val436Leu Single submitter ⚠
p.Val470Met Single submitter ⚠
p.Val617Leu Single submitter ⚠
p.Val648Ala Single submitter ⚠
p.Val670Met Single submitter ⚠
p.Val67Ile Single submitter ⚠
p.Val727Leu Single submitter ⚠
p.Val731Met Single submitter ⚠
p.Val732Ala Single submitter ⚠
p.Val819Glu Single submitter ⚠
p.Val865Met Single submitter ⚠
p.Val871Met Single submitter ⚠
p.Val903Met Single submitter ⚠
p.Val932Leu Single submitter ⚠