ADGRF4 — 99 ClinVar variants
All ClinVar germline ADGRF4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 88 flagged for review →
3 Likely benign · 96 Uncertain significance
Full ADGRF4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 88
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 81
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADGRF4 p.Ala197Thr Uncertain significance Single submitter
- ADGRF4 p.Ala198Asp Uncertain significance Single submitter
- ADGRF4 p.Ala680Pro Uncertain significance Single submitter
- ADGRF4 p.Ala680Ser Uncertain significance Single submitter
- ADGRF4 p.Arg107His Uncertain significance Single submitter
- ADGRF4 p.Arg136Cys Uncertain significance Single submitter
- ADGRF4 p.Arg136His Uncertain significance Single submitter
- ADGRF4 p.Arg314Gly Uncertain significance Single submitter
- ADGRF4 p.Arg343Cys Uncertain significance Single submitter
- ADGRF4 p.Arg343His Uncertain significance Single submitter
- ADGRF4 p.Arg357Lys Uncertain significance Single submitter
- ADGRF4 p.Arg377His Uncertain significance Single submitter
- ADGRF4 p.Arg429Trp Uncertain significance Single submitter
- ADGRF4 p.Arg507His Uncertain significance Single submitter
- ADGRF4 p.Arg507Pro Uncertain significance Single submitter
- ADGRF4 p.Arg513Gln Uncertain significance Single submitter
- ADGRF4 p.Arg693Cys Uncertain significance Single submitter
- ADGRF4 p.Asn248Lys Uncertain significance Single submitter
- ADGRF4 p.Asn340Ser Uncertain significance Single submitter
- ADGRF4 p.Asn379His Uncertain significance Single submitter
- ADGRF4 p.Asp173His Uncertain significance Single submitter
- ADGRF4 p.Asp661Gly Uncertain significance Single submitter
- ADGRF4 p.Cys406Tyr Uncertain significance Single submitter
- ADGRF4 p.Gln224Leu Uncertain significance Single submitter
- ADGRF4 p.Gln84Glu Uncertain significance Single submitter
- ADGRF4 p.Glu165Gly Uncertain significance Single submitter
- ADGRF4 p.Glu181Asp Uncertain significance Single submitter
- ADGRF4 p.Glu253Ala Uncertain significance Single submitter
- ADGRF4 p.Glu53Lys Uncertain significance Single submitter
- ADGRF4 p.Gly33Glu Uncertain significance Single submitter
- ADGRF4 p.Gly54Arg Uncertain significance Single submitter
- ADGRF4 p.Gly54Glu Uncertain significance Single submitter
- ADGRF4 p.Gly687Glu Uncertain significance Single submitter
- ADGRF4 p.His462Tyr Uncertain significance Single submitter
- ADGRF4 p.Ile193Asn Uncertain significance Single submitter
- ADGRF4 p.Ile339Thr Uncertain significance Single submitter
- ADGRF4 p.Ile407Thr Uncertain significance Single submitter
- ADGRF4 p.Ile465Val Uncertain significance Single submitter
- ADGRF4 p.Ile564Leu Uncertain significance Single submitter
- ADGRF4 p.Ile609Val Uncertain significance Single submitter
- ADGRF4 p.Ile626Met Uncertain significance Single submitter
- ADGRF4 p.Ile659Lys Uncertain significance Single submitter
- ADGRF4 p.Ile74Thr Uncertain significance Single submitter
- ADGRF4 p.Ile74Val Uncertain significance Single submitter
- ADGRF4 p.Leu120Ile Uncertain significance Single submitter
- ADGRF4 p.Leu574Met Uncertain significance Single submitter
- ADGRF4 p.Lys338Arg Uncertain significance Single submitter
- ADGRF4 p.Met183Val Uncertain significance Single submitter
- ADGRF4 p.Met260Ile Uncertain significance Single submitter
- ADGRF4 p.Met472Ile Uncertain significance Single submitter
- ADGRF4 p.Met9Thr Uncertain significance Single submitter
- ADGRF4 p.Phe562Leu Uncertain significance Single submitter
- ADGRF4 p.Pro140Arg Uncertain significance Single submitter
- ADGRF4 p.Pro43His Uncertain significance Single submitter
- ADGRF4 p.Pro65Ser Uncertain significance Single submitter
- ADGRF4 p.Ser102Leu Uncertain significance Single submitter
- ADGRF4 p.Ser175Tyr Uncertain significance Single submitter
- ADGRF4 p.Ser26Thr Uncertain significance Single submitter
- ADGRF4 p.Ser395Leu Uncertain significance Single submitter
- ADGRF4 p.Ser486Cys Uncertain significance Single submitter
- ADGRF4 p.Ser592Cys Uncertain significance Single submitter
- ADGRF4 p.Ser674Leu Uncertain significance Single submitter
- ADGRF4 p.Thr265Ala Uncertain significance Single submitter
- ADGRF4 p.Thr477Ile Uncertain significance Single submitter
- ADGRF4 p.Thr624Ser Uncertain significance Single submitter
- ADGRF4 p.Thr632Met Uncertain significance Single submitter
- ADGRF4 p.Trp202Arg Uncertain significance Single submitter
- ADGRF4 p.Trp284Cys Uncertain significance Single submitter
- ADGRF4 p.Trp490Arg Uncertain significance Single submitter
- ADGRF4 p.Tyr186Cys Uncertain significance Single submitter
- ADGRF4 p.Tyr24Cys Uncertain significance Single submitter
- ADGRF4 p.Tyr500Phe Uncertain significance Single submitter
- ADGRF4 p.Tyr543Cys Uncertain significance Single submitter
- ADGRF4 p.Val316Ile Uncertain significance Single submitter
- ADGRF4 p.Val417Phe Uncertain significance Single submitter
- ADGRF4 p.Val431Ala Uncertain significance Single submitter
- ADGRF4 p.Val441Met Uncertain significance Single submitter
- ADGRF4 p.Val568Ile Uncertain significance Single submitter
- ADGRF4 p.Val580Ile Uncertain significance Single submitter
- ADGRF4 p.Val597Met Uncertain significance Single submitter
- ADGRF4 p.Ala475Ser Uncertain significance No assertion criteria
Predictors split 7
The independent predictors disagree with each other — read with care.
- ADGRF4 p.Asn191Lys Uncertain significance Single submitter
- ADGRF4 p.Gly522Ser Uncertain significance Single submitter
- ADGRF4 p.Ile569Thr Uncertain significance Single submitter
- ADGRF4 p.Ile654Thr Uncertain significance Single submitter
- ADGRF4 p.Met391Thr Uncertain significance Single submitter
- ADGRF4 p.Ser674Pro Uncertain significance Single submitter
- ADGRF4 p.Val476Met Uncertain significance Single submitter
All ADGRF4 variants
Likely benign 3
- p.Arg180Gln Single submitter
- p.Asn372= Single submitter
- p.Gln64Arg Single submitter
Uncertain significance 96
- p.Ala197Thr Single submitter ⚠
- p.Ala198Asp Single submitter ⚠
- p.Ala495Thr Single submitter
- p.Ala561Thr Single submitter
- p.Ala680Pro Single submitter ⚠
- p.Ala680Ser Single submitter ⚠
- p.Arg107His Single submitter ⚠
- p.Arg136Cys Single submitter ⚠
- p.Arg136His Single submitter ⚠
- p.Arg314Gly Single submitter ⚠
- p.Arg343Cys Single submitter ⚠
- p.Arg343His Single submitter ⚠
- p.Arg357Lys Single submitter ⚠
- p.Arg377His Single submitter ⚠
- p.Arg429Trp Single submitter ⚠
- p.Arg507His Single submitter ⚠
- p.Arg507Pro Single submitter ⚠
- p.Arg513Gln Single submitter ⚠
- p.Arg693Cys Single submitter ⚠
- p.Asn191Lys Single submitter ⚠
- p.Asn248Lys Single submitter ⚠
- p.Asn340Ser Single submitter ⚠
- p.Asn379His Single submitter ⚠
- p.Asp173His Single submitter ⚠
- p.Asp661Gly Single submitter ⚠
- p.Cys406Tyr Single submitter ⚠
- p.Gln224Leu Single submitter ⚠
- p.Gln84Glu Single submitter ⚠
- p.Glu165Gly Single submitter ⚠
- p.Glu181Asp Single submitter ⚠
- p.Glu253Ala Single submitter ⚠
- p.Glu53Lys Single submitter ⚠
- p.Gly33Glu Single submitter ⚠
- p.Gly522Ser Single submitter ⚠
- p.Gly54Arg Single submitter ⚠
- p.Gly54Glu Single submitter ⚠
- p.Gly687Glu Single submitter ⚠
- p.His462Tyr Single submitter ⚠
- p.Ile193Asn Single submitter ⚠
- p.Ile339Thr Single submitter ⚠
- p.Ile407Thr Single submitter ⚠
- p.Ile465Val Single submitter ⚠
- p.Ile564Leu Single submitter ⚠
- p.Ile569Thr Single submitter ⚠
- p.Ile609Val Single submitter ⚠
- p.Ile626Met Single submitter ⚠
- p.Ile654Thr Single submitter ⚠
- p.Ile659Lys Single submitter ⚠
- p.Ile74Thr Single submitter ⚠
- p.Ile74Val Single submitter ⚠
- p.Leu120Ile Single submitter ⚠
- p.Leu194Phe Single submitter
- p.Leu283Pro Single submitter
- p.Leu409Phe Single submitter
- p.Leu574Met Single submitter ⚠
- p.Lys338Arg Single submitter ⚠
- p.Met183Val Single submitter ⚠
- p.Met260Ile Single submitter ⚠
- p.Met391Thr Single submitter ⚠
- p.Met472Ile Single submitter ⚠
- p.Met9Thr Single submitter ⚠
- p.Phe562Leu Single submitter ⚠
- p.Phe651Tyr Single submitter
- p.Pro140Arg Single submitter ⚠
- p.Pro43His Single submitter ⚠
- p.Pro565Leu Single submitter
- p.Pro65Ser Single submitter ⚠
- p.Ser102Leu Single submitter ⚠
- p.Ser175Tyr Single submitter ⚠
- p.Ser26Thr Single submitter ⚠
- p.Ser395Leu Single submitter ⚠
- p.Ser486Cys Single submitter ⚠
- p.Ser592Cys Single submitter ⚠
- p.Ser674Leu Single submitter ⚠
- p.Ser674Pro Single submitter ⚠
- p.Thr265Ala Single submitter ⚠
- p.Thr477Ile Single submitter ⚠
- p.Thr624Ser Single submitter ⚠
- p.Thr632Met Single submitter ⚠
- p.Trp202Arg Single submitter ⚠
- p.Trp284Cys Single submitter ⚠
- p.Trp490Arg Single submitter ⚠
- p.Tyr186Cys Single submitter ⚠
- p.Tyr24Cys Single submitter ⚠
- p.Tyr500Phe Single submitter ⚠
- p.Tyr543Cys Single submitter ⚠
- p.Val316Ile Single submitter ⚠
- p.Val417Phe Single submitter ⚠
- p.Val431Ala Single submitter ⚠
- p.Val441Met Single submitter ⚠
- p.Val476Met Single submitter ⚠
- p.Val568Ile Single submitter ⚠
- p.Val580Ala Single submitter
- p.Val580Ile Single submitter ⚠
- p.Val597Met Single submitter ⚠
- p.Ala475Ser No assertion criteria ⚠