ADGRF5 — 183 ClinVar variants

All ClinVar germline ADGRF5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 165 flagged for review →

15 Likely benign · 168 Uncertain significance

Full ADGRF5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 165

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 148

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 17

The independent predictors disagree with each other — read with care.

All ADGRF5 variants

Likely benign 15

p.Ala759Val Single submitter
p.Arg1078His Single submitter
p.Arg206Trp Single submitter
p.Asn963Asp Single submitter
p.Gln371Arg Single submitter
p.Glu951Lys Single submitter
p.Gly210Arg Single submitter
p.Met12Val Single submitter
p.Pro41Leu Single submitter
p.Ser1342Tyr Single submitter
p.Ser494= Single submitter
p.Thr932Ile Single submitter
p.Tyr513His Single submitter
p.Val673Ile Single submitter
p.Val692Ile Single submitter

Uncertain significance 168

p.Ala1064Val Single submitter ⚠
p.Ala1072Thr Single submitter ⚠
p.Ala1072Val Single submitter ⚠
p.Ala1088Ser Single submitter ⚠
p.Ala1179Glu Single submitter ⚠
p.Ala268Thr Single submitter ⚠
p.Ala324Val Single submitter ⚠
p.Ala457Thr Single submitter ⚠
p.Ala54Gly Single submitter ⚠
p.Ala759Thr Single submitter ⚠
p.Ala910Gly Single submitter ⚠
p.Arg1045Gln Single submitter ⚠
p.Arg1114Cys Single submitter
p.Arg1153Trp Single submitter ⚠
p.Arg130Trp Single submitter ⚠
p.Arg142Cys Single submitter ⚠
p.Arg206Gln Single submitter ⚠
p.Arg305Cys Single submitter ⚠
p.Arg520Ser Single submitter ⚠
p.Asn1255Ser Single submitter ⚠
p.Asn1279Ser Single submitter ⚠
p.Asn160Ser Single submitter ⚠
p.Asn301Ser Single submitter ⚠
p.Asn328Ser Single submitter ⚠
p.Asn385Ser Single submitter ⚠
p.Asn472Lys Single submitter ⚠
p.Asn691Asp Single submitter ⚠
p.Asn726His Single submitter ⚠
p.Asn820Ser Single submitter ⚠
p.Asn944Lys Single submitter ⚠
p.Asn944Ser Single submitter ⚠
p.Asp169Val Single submitter ⚠
p.Asp185His Single submitter ⚠
p.Asp262Gly Single submitter ⚠
p.Asp262Tyr Single submitter ⚠
p.Asp383Asn Single submitter ⚠
p.Asp419Gly Single submitter ⚠
p.Asp419Val Single submitter ⚠
p.Asp597His Single submitter ⚠
p.Asp639Gly Single submitter ⚠
p.Asp742Gly Single submitter ⚠
p.Asp757His Single submitter ⚠
p.Asp778Glu Single submitter ⚠
p.Asp78Tyr Single submitter ⚠
p.Cys1138Phe Single submitter ⚠
p.Cys122Trp Single submitter ⚠
p.Cys164Tyr Single submitter ⚠
p.Gln167Arg Single submitter ⚠
p.Gln314His Single submitter ⚠
p.Gln712Arg Single submitter ⚠
p.Gln712His Single submitter ⚠
p.Gln712Lys Single submitter ⚠
p.Gln892Pro Single submitter ⚠
p.Glu1154Lys Single submitter ⚠
p.Glu141Lys Single submitter ⚠
p.Glu249Asp Single submitter ⚠
p.Glu38Gln Single submitter ⚠
p.Glu527Lys Single submitter ⚠
p.Gly1019Glu Single submitter ⚠
p.Gly161Arg Single submitter ⚠
p.Gly181Asp Single submitter ⚠
p.Gly343Val Single submitter ⚠
p.Gly395Asp Single submitter ⚠
p.Gly395Val Single submitter ⚠
p.Gly439Arg Single submitter ⚠
p.Gly43Ser Single submitter ⚠
p.Gly950Ser Single submitter ⚠
p.Gly978Ser Single submitter ⚠
p.Gly980Ala Single submitter ⚠
p.Gly980Val Single submitter ⚠
p.Ile1015Thr Single submitter
p.Ile1024Thr Single submitter ⚠
p.Ile1080Met Single submitter ⚠
p.Ile1130Thr Single submitter ⚠
p.Ile1182Thr Single submitter ⚠
p.Ile1191Thr Single submitter ⚠
p.Ile1221Thr Single submitter ⚠
p.Ile1309Thr Single submitter ⚠
p.Ile282Ser Single submitter ⚠
p.Ile313Val Single submitter ⚠
p.Ile337Val Single submitter ⚠
p.Ile412Phe Single submitter ⚠
p.Ile452Val Single submitter ⚠
p.Ile69Asn Single submitter ⚠
p.Ile700Thr Single submitter ⚠
p.Ile736Met Single submitter ⚠
p.Ile802Val Single submitter ⚠
p.Ile80Val Single submitter ⚠
p.Ile913Ser Single submitter ⚠
p.Ile91Thr Single submitter ⚠
p.Ile99Val Single submitter ⚠
p.Leu1007Ile Single submitter ⚠
p.Leu1109Phe Single submitter ⚠
p.Leu1140Phe Single submitter ⚠
p.Leu1227Phe Single submitter
p.Leu1316Phe Single submitter ⚠
p.Leu166Phe Single submitter ⚠
p.Leu565Pro Single submitter ⚠
p.Leu803Ile Single submitter ⚠
p.Leu808Phe Single submitter ⚠
p.Leu888Val Single submitter ⚠
p.Lys1083Gln Single submitter ⚠
p.Lys550Asn Single submitter ⚠
p.Lys618Glu Single submitter ⚠
p.Lys737Asn Single submitter ⚠
p.Lys737Glu Single submitter ⚠
p.Met368Ile Single submitter ⚠
p.Met657Val Single submitter ⚠
p.Met792Ile Single submitter ⚠
p.Met856Ile Single submitter ⚠
p.Met924Leu Single submitter ⚠
p.Met940Val Single submitter ⚠
p.Met997Ile Single submitter ⚠
p.Phe602Leu Single submitter ⚠
p.Phe626Leu Single submitter ⚠
p.Phe76Ser Single submitter ⚠
p.Pro1178Ala Single submitter ⚠
p.Pro129Leu Single submitter ⚠
p.Pro162Thr Single submitter ⚠
p.Pro41Gln Single submitter ⚠
p.Pro58Ser Single submitter ⚠
p.Pro655Arg Single submitter ⚠
p.Pro724Ala Single submitter ⚠
p.Pro767Leu Single submitter ⚠
p.Pro90Ser Single submitter ⚠
p.Ser1040Leu Single submitter ⚠
p.Ser1284Leu Single submitter ⚠
p.Ser1334Phe Single submitter ⚠
p.Ser1343Trp Single submitter ⚠
p.Ser29Phe Single submitter ⚠
p.Ser440Leu Single submitter ⚠
p.Ser481Phe Single submitter ⚠
p.Ser552Leu Single submitter ⚠
p.Ser583Gly Single submitter ⚠
p.Ser838Pro Single submitter ⚠
p.Ser847Cys Single submitter ⚠
p.Ser855Ile Single submitter ⚠
p.Ser861Asn Single submitter ⚠
p.Ser896Ala Single submitter ⚠
p.Ser896Pro Single submitter ⚠
p.Thr1046Asn Single submitter ⚠
p.Thr1084Ser Single submitter ⚠
p.Thr1190Ile Single submitter ⚠
p.Thr1237Ile Single submitter ⚠
p.Thr1322Met Single submitter ⚠
p.Thr1331Ile Single submitter ⚠
p.Thr30Ala Single submitter ⚠
p.Thr330Ile Single submitter ⚠
p.Thr415Ala Single submitter ⚠
p.Thr443Pro Single submitter ⚠
p.Thr466Ala Single submitter ⚠
p.Thr519Arg Single submitter ⚠
p.Thr601Ile Single submitter ⚠
p.Thr637Pro Single submitter ⚠
p.Thr747Ala Single submitter ⚠
p.Thr927Ile Single submitter ⚠
p.Trp119Arg Single submitter ⚠
p.Tyr1136Cys Single submitter ⚠
p.Tyr455Cys Single submitter ⚠
p.Val1041Ala Single submitter ⚠
p.Val1100Ile Single submitter ⚠
p.Val1246Leu Single submitter ⚠
p.Val170Leu Single submitter ⚠
p.Val502Ala Single submitter ⚠
p.Val631Leu Single submitter ⚠
p.Val640Met Single submitter ⚠
p.Val795Met Single submitter ⚠
p.Val898Ile Single submitter ⚠