ADGRG3 — 103 ClinVar variants

All ClinVar germline ADGRG3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 91 flagged for review →

13 Likely benign · 90 Uncertain significance

Full ADGRG3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 91

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 45

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 46

The independent predictors disagree with each other — read with care.

All ADGRG3 variants

Likely benign 13

p.Arg167Gln Single submitter
p.Arg180His Single submitter ⚠
p.Arg469Gln Single submitter
p.Arg473Trp Single submitter
p.Asp60Asn Single submitter
p.Gly169Ser Single submitter
p.Gly175Ser Single submitter
p.Pro17Leu Single submitter
p.Ser545= Single submitter
p.Thr224Pro Single submitter
p.Val454Ala Single submitter
p.Val486Leu Single submitter
p.Val503Ile Single submitter

Uncertain significance 90

p.Ala253Thr Single submitter ⚠
p.Ala311Val Single submitter ⚠
p.Ala543Ser Single submitter ⚠
p.Ala546Thr Single submitter ⚠
p.Ala9Pro Single submitter ⚠
p.Arg139Gln Single submitter ⚠
p.Arg149His Single submitter ⚠
p.Arg180Cys Single submitter ⚠
p.Arg297Gln Single submitter ⚠
p.Arg341Gln Single submitter ⚠
p.Arg341Pro Single submitter ⚠
p.Arg341Trp Single submitter ⚠
p.Arg414Leu Single submitter ⚠
p.Arg423Cys Single submitter ⚠
p.Arg423His Single submitter ⚠
p.Arg462His Single submitter ⚠
p.Arg469Pro Single submitter ⚠
p.Arg473Gln Single submitter ⚠
p.Arg55Gly Single submitter ⚠
p.Asp261Glu Single submitter ⚠
p.Asp40Asn Single submitter ⚠
p.Asp46Glu Single submitter ⚠
p.Asp46Gly Single submitter ⚠
p.Cys246Tyr Single submitter ⚠
p.Cys54Arg Single submitter ⚠
p.Cys54Phe Single submitter ⚠
p.Gln97Arg Single submitter ⚠
p.Glu105Gly Single submitter ⚠
p.Glu124Lys Single submitter ⚠
p.Glu412Ala Single submitter ⚠
p.Glu75Gln Single submitter ⚠
p.Glu75Gly Single submitter ⚠
p.Gly169Asp Single submitter ⚠
p.Gly169Val Single submitter ⚠
p.Gly357Cys Single submitter ⚠
p.Gly404Ser Single submitter ⚠
p.Gly470Arg Single submitter ⚠
p.Ile281Phe Single submitter ⚠
p.Leu168Ile Single submitter ⚠
p.Leu16Phe Single submitter ⚠
p.Leu254Met Single submitter ⚠
p.Leu268Phe Single submitter ⚠
p.Leu316Val Single submitter ⚠
p.Leu321Val Single submitter ⚠
p.Lys301Arg Single submitter ⚠
p.Lys471Arg Single submitter ⚠
p.Lys80Gln Single submitter ⚠
p.Met280Thr Single submitter ⚠
p.Met38Leu Single submitter ⚠
p.Phe371Ser Single submitter ⚠
p.Phe375Val Single submitter ⚠
p.Phe443Leu Single submitter ⚠
p.Pro117Leu Single submitter ⚠
p.Pro142Ser Single submitter ⚠
p.Pro166Thr Single submitter ⚠
p.Pro239Ser Single submitter ⚠
p.Pro258Leu Single submitter ⚠
p.Ser136Arg Single submitter ⚠
p.Ser136Cys Single submitter ⚠
p.Ser185Asn Single submitter ⚠
p.Ser230Phe Single submitter ⚠
p.Ser263Cys Single submitter ⚠
p.Ser331Leu Single submitter ⚠
p.Ser483Leu Single submitter ⚠
p.Ser528Gly Single submitter ⚠
p.Ser530Arg Single submitter ⚠
p.Ser545Cys Single submitter ⚠
p.Ser57Leu Single submitter ⚠
p.Thr18Ile Single submitter ⚠
p.Thr192Pro Single submitter ⚠
p.Thr225Ser Single submitter ⚠
p.Thr235Lys Single submitter ⚠
p.Thr235Met Single submitter ⚠
p.Thr242Ser Single submitter ⚠
p.Thr264Met Single submitter ⚠
p.Thr397Pro Single submitter ⚠
p.Thr434Ser Single submitter ⚠
p.Thr478Asn Single submitter ⚠
p.Thr52Ala Single submitter ⚠
p.Tyr39Phe Single submitter ⚠
p.Tyr438His Single submitter ⚠
p.Val131Leu Single submitter ⚠
p.Val176Leu Single submitter ⚠
p.Val176Met Single submitter ⚠
p.Val201Ile Single submitter ⚠
p.Val278Ile Single submitter ⚠
p.Val385Met Single submitter ⚠
p.Val435Ile Single submitter ⚠
p.Val486Gly Single submitter ⚠
p.Val96Gly Single submitter ⚠