ADGRL2 — 183 ClinVar variants
All ClinVar germline ADGRL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 149 flagged for review →
13 Benign · 22 Likely benign · 148 Uncertain significance
Full ADGRL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 149
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 97
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADGRL2 p.Ala160Val Uncertain significance Single submitter
- ADGRL2 p.Ala191Ser Uncertain significance Single submitter
- ADGRL2 p.Ala402Thr Uncertain significance Single submitter
- ADGRL2 p.Ala547Thr Uncertain significance Single submitter
- ADGRL2 p.Ala705Thr Uncertain significance Single submitter
- ADGRL2 p.Ala841Thr Uncertain significance Single submitter
- ADGRL2 p.Ala913Val Uncertain significance Single submitter
- ADGRL2 p.Ala918Pro Uncertain significance Single submitter
- ADGRL2 p.Arg1131His Uncertain significance Single submitter
- ADGRL2 p.Arg1408Lys Uncertain significance Single submitter
- ADGRL2 p.Arg210Gln Uncertain significance Single submitter
- ADGRL2 p.Arg313Cys Uncertain significance Single submitter
- ADGRL2 p.Arg568Gly Uncertain significance Single submitter
- ADGRL2 p.Arg725Gln Uncertain significance Single submitter
- ADGRL2 p.Arg800Gly Uncertain significance Single submitter
- ADGRL2 p.Arg96Ser Uncertain significance Single submitter
- ADGRL2 p.Asn1162Ser Uncertain significance Single submitter
- ADGRL2 p.Asn1377Ser Uncertain significance Single submitter
- ADGRL2 p.Asn548Ser Uncertain significance Single submitter
- ADGRL2 p.Asn619His Uncertain significance Single submitter
- ADGRL2 p.Asp1414Glu Uncertain significance Single submitter
- ADGRL2 p.Asp646Asn Uncertain significance Single submitter
- ADGRL2 p.Cys1109Tyr Uncertain significance Single submitter
- ADGRL2 p.Cys525Tyr Uncertain significance Single submitter
- ADGRL2 p.Cys865Ser Uncertain significance Single submitter
- ADGRL2 p.Cys891Ser Uncertain significance Single submitter
- ADGRL2 p.Gln430Glu Uncertain significance Single submitter
- ADGRL2 p.Gln686Arg Uncertain significance Single submitter
- ADGRL2 p.Gln686Lys Uncertain significance Single submitter
- ADGRL2 p.Glu1292Ala Uncertain significance Single submitter
- ADGRL2 p.Glu1356Lys Uncertain significance Single submitter
- ADGRL2 p.Glu24Gln Uncertain significance Single submitter
- ADGRL2 p.Gly1357Glu Uncertain significance Single submitter
- ADGRL2 p.Gly447Glu Uncertain significance Single submitter
- ADGRL2 p.Gly693Ser Uncertain significance Single submitter
- ADGRL2 p.Gly728Glu Uncertain significance Single submitter
- ADGRL2 p.His1118Arg Uncertain significance Single submitter
- ADGRL2 p.His1329Gln Uncertain significance Single submitter
- ADGRL2 p.His1372Tyr Uncertain significance Single submitter
- ADGRL2 p.His989Arg Uncertain significance Single submitter
- ADGRL2 p.Ile1311Val Uncertain significance Single submitter
- ADGRL2 p.Ile1435Met Uncertain significance Single submitter
- ADGRL2 p.Ile15Thr Uncertain significance Single submitter
- ADGRL2 p.Ile15Val Uncertain significance Single submitter
- ADGRL2 p.Ile421Val Uncertain significance Single submitter
- ADGRL2 p.Ile613Thr Uncertain significance Single submitter
- ADGRL2 p.Ile672Thr Uncertain significance Single submitter
- ADGRL2 p.Ile758Thr Uncertain significance Single submitter
- ADGRL2 p.Leu1112Phe Uncertain significance Single submitter
- ADGRL2 p.Leu1293Pro Uncertain significance Single submitter
- ADGRL2 p.Leu1337Ile Uncertain significance Single submitter
- ADGRL2 p.Leu417Val Uncertain significance Single submitter
- ADGRL2 p.Leu49Val Uncertain significance Single submitter
- ADGRL2 p.Lys1022Thr Uncertain significance Single submitter
- ADGRL2 p.Lys1248Asn Uncertain significance Single submitter
- ADGRL2 p.Lys1287Gln Uncertain significance Single submitter
- ADGRL2 p.Met1020Val Uncertain significance Single submitter
- ADGRL2 p.Met1319Thr Uncertain significance Single submitter
- ADGRL2 p.Met1420Val Uncertain significance Single submitter
- ADGRL2 p.Met491Val Uncertain significance Single submitter
- ADGRL2 p.Met509Val Uncertain significance Single submitter
- ADGRL2 p.Met802Val Uncertain significance Single submitter
- ADGRL2 p.Phe236Tyr Uncertain significance Single submitter
- ADGRL2 p.Phe302Tyr Uncertain significance Single submitter
- ADGRL2 p.Phe466Ser Uncertain significance Single submitter
- ADGRL2 p.Phe901Ile Uncertain significance Single submitter
- ADGRL2 p.Phe924Leu Uncertain significance Single submitter
- ADGRL2 p.Phe925Ile Uncertain significance Single submitter
- ADGRL2 p.Pro1117Leu Uncertain significance Single submitter
- ADGRL2 p.Pro1299Ser Uncertain significance Single submitter
- ADGRL2 p.Pro1324Arg Uncertain significance Single submitter
- ADGRL2 p.Pro1394Leu Uncertain significance Single submitter
- ADGRL2 p.Pro259Ala Uncertain significance Single submitter
- ADGRL2 p.Pro32Ala Uncertain significance Single submitter
- ADGRL2 p.Pro586Arg Uncertain significance Single submitter
- ADGRL2 p.Ser1031Cys Uncertain significance Single submitter
- ADGRL2 p.Ser1133Tyr Uncertain significance Single submitter
- ADGRL2 p.Ser1355Thr Uncertain significance Single submitter
- ADGRL2 p.Ser1380Cys Uncertain significance Single submitter
- ADGRL2 p.Ser3Phe Uncertain significance Single submitter
- ADGRL2 p.Ser634Ala Uncertain significance Single submitter
- ADGRL2 p.Ser881Asn Uncertain significance Single submitter
- ADGRL2 p.Thr1136Ser Uncertain significance Single submitter
- ADGRL2 p.Thr305Met Uncertain significance Single submitter
- ADGRL2 p.Thr428Ala Uncertain significance Single submitter
- ADGRL2 p.Thr872Ile Uncertain significance Single submitter
- ADGRL2 p.Tyr1071His Uncertain significance Single submitter
- ADGRL2 p.Tyr1251His Uncertain significance Single submitter
- ADGRL2 p.Tyr182Cys Uncertain significance Single submitter
- ADGRL2 p.Tyr205His Uncertain significance Single submitter
- ADGRL2 p.Tyr346His Uncertain significance Single submitter
- ADGRL2 p.Tyr956Asn Uncertain significance Single submitter
- ADGRL2 p.Val1255Leu Uncertain significance Single submitter
- ADGRL2 p.Val383Met Uncertain significance Single submitter
- ADGRL2 p.Val404Ala Uncertain significance Single submitter
- ADGRL2 p.Val454Ala Uncertain significance Single submitter
- ADGRL2 p.Val968Gly Uncertain significance Single submitter
Predictors split 52
The independent predictors disagree with each other — read with care.
- ADGRL2 p.Ala1070Thr Uncertain significance Single submitter
- ADGRL2 p.Ala1090Val Uncertain significance Single submitter
- ADGRL2 p.Ala170Val Uncertain significance Single submitter
- ADGRL2 p.Ala29Val Uncertain significance Single submitter
- ADGRL2 p.Ala638Gly Uncertain significance Single submitter
- ADGRL2 p.Ala705Val Uncertain significance Single submitter
- ADGRL2 p.Ala973Thr Uncertain significance Single submitter
- ADGRL2 p.Arg1283Trp Uncertain significance Single submitter
- ADGRL2 p.Arg1459Ser Uncertain significance Single submitter
- ADGRL2 p.Arg354Gln Uncertain significance Single submitter
- ADGRL2 p.Arg494Gln Uncertain significance Single submitter
- ADGRL2 p.Asn1280Lys Uncertain significance Single submitter
- ADGRL2 p.Asn375Ser Uncertain significance Single submitter
- ADGRL2 p.Asn386Ser Uncertain significance Single submitter
- ADGRL2 p.Asp1160Ala Uncertain significance Single submitter
- ADGRL2 p.Asp1379Glu Uncertain significance Single submitter
- ADGRL2 p.Asp1379Gly Uncertain significance Single submitter
- ADGRL2 p.Asp69Glu Uncertain significance Single submitter
- ADGRL2 p.Cys1260Tyr Uncertain significance Single submitter
- ADGRL2 p.Glu194Lys Uncertain significance Single submitter
- ADGRL2 p.His837Asn Uncertain significance Single submitter
- ADGRL2 p.Ile369Val Uncertain significance Single submitter
- ADGRL2 p.Ile59Val Uncertain significance Single submitter
- ADGRL2 p.Ile916Met Uncertain significance Single submitter
- ADGRL2 p.Ile999Thr Uncertain significance Single submitter
- ADGRL2 p.Leu1264Met Uncertain significance Single submitter
- ADGRL2 p.Leu507Phe Uncertain significance Single submitter
- ADGRL2 p.Leu533Met Uncertain significance Single submitter
- ADGRL2 p.Lys518Glu Uncertain significance Single submitter
- ADGRL2 p.Met643Val Uncertain significance Single submitter
- ADGRL2 p.Met803Ile Uncertain significance Single submitter
- ADGRL2 p.Phe1156Val Uncertain significance Single submitter
- ADGRL2 p.Phe730Tyr Uncertain significance Single submitter
- ADGRL2 p.Phe899Leu Uncertain significance Single submitter
- ADGRL2 p.Pro1235Leu Uncertain significance Single submitter
- ADGRL2 p.Ser393Pro Uncertain significance Single submitter
- ADGRL2 p.Ser423Leu Uncertain significance Single submitter
- ADGRL2 p.Ser511Pro Uncertain significance Single submitter
- ADGRL2 p.Ser881Gly Uncertain significance Single submitter
- ADGRL2 p.Thr1294Met Uncertain significance Single submitter
- ADGRL2 p.Thr456Ala Uncertain significance Single submitter
- ADGRL2 p.Thr822Ala Uncertain significance Single submitter
- ADGRL2 p.Thr822Met Uncertain significance Single submitter
- ADGRL2 p.Thr982Ala Uncertain significance Single submitter
- ADGRL2 p.Tyr1443Cys Uncertain significance Single submitter
- ADGRL2 p.Val1041Gly Uncertain significance Single submitter
- ADGRL2 p.Val1068Met Uncertain significance Single submitter
- ADGRL2 p.Val1255Met Uncertain significance Single submitter
- ADGRL2 p.Val567Met Uncertain significance Single submitter
- ADGRL2 p.Val678Leu Uncertain significance Single submitter
- ADGRL2 p.Val971Phe Uncertain significance Single submitter
-
ADGRL2 p.Ile1338Thr
Likely benign
No assertion criteria
ADGRL2-related disorder
All ADGRL2 variants
Benign 13
- p.Thr1294= Multiple submitters
- p.Ser766= Single submitter
- c.3637+309A>G No assertion criteria ADGRL2-related disorder
- p.Arg1127= No assertion criteria ADGRL2-related disorder
- p.Arg1389Lys No assertion criteria ADGRL2-related disorder
- p.Asn1202Ser No assertion criteria ADGRL2-related disorder
- p.Asp578= No assertion criteria ADGRL2-related disorder
- p.Gly1249Val No assertion criteria ADGRL2-related disorder
- p.Gly440= No assertion criteria ADGRL2-related disorder
- p.Pro1394Ala No assertion criteria ADGRL2-related disorder
- p.Ser1305Gly No assertion criteria ADGRL2-related disorder
- p.Tyr1361Cys No assertion criteria ADGRL2-related disorder
- p.Val1297Ile No assertion criteria ADGRL2-related disorder
Likely benign 22
- p.Lys555Arg Multiple submitters
- p.Ala1230Pro Single submitter
- p.Arg9Gln Single submitter
- p.Asn1252Ser Single submitter
- p.Asn342= Single submitter
- p.Glu765= Single submitter
- p.His1247Arg Single submitter
- p.Ser41= Single submitter
- p.Ser759= Single submitter
- p.Thr463= Single submitter
- c.2734-4G>A No assertion criteria ADGRL2-related disorder
- c.3509-9_3509-8del No assertion criteria ADGRL2-related disorder
- c.-9G>A No assertion criteria ADGRL2-related disorder
- p.Ala1369= No assertion criteria ADGRL2-related disorder
- p.Arg747Leu No assertion criteria ADGRL2-related disorder
- p.Asn1242= No assertion criteria ADGRL2-related disorder
- p.Ile1338Thr No assertion criteria ADGRL2-related disorder ⚠
- p.Leu581= No assertion criteria ADGRL2-related disorder
- p.Lys630= No assertion criteria ADGRL2-related disorder
- p.Ser539= No assertion criteria ADGRL2-related disorder
- p.Thr107= No assertion criteria ADGRL2-related disorder
- p.Thr1214Asn No assertion criteria ADGRL2-related disorder
Uncertain significance 148
- p.Ala1070Thr Single submitter ⚠
- p.Ala1090Val Single submitter ⚠
- p.Ala160Val Single submitter ⚠
- p.Ala170Val Single submitter ⚠
- p.Ala191Ser Single submitter ⚠
- p.Ala29Val Single submitter ⚠
- p.Ala402Thr Single submitter ⚠
- p.Ala547Thr Single submitter ⚠
- p.Ala638Gly Single submitter ⚠
- p.Ala705Thr Single submitter ⚠
- p.Ala705Val Single submitter ⚠
- p.Ala841Thr Single submitter ⚠
- p.Ala913Val Single submitter ⚠
- p.Ala918Pro Single submitter ⚠
- p.Ala973Thr Single submitter ⚠
- p.Arg1131His Single submitter ⚠
- p.Arg1283Trp Single submitter ⚠
- p.Arg1408Lys Single submitter ⚠
- p.Arg1459Ser Single submitter ⚠
- p.Arg210Gln Single submitter ⚠
- p.Arg313Cys Single submitter ⚠
- p.Arg354Gln Single submitter ⚠
- p.Arg494Gln Single submitter ⚠
- p.Arg568Gly Single submitter ⚠
- p.Arg725Gln Single submitter ⚠
- p.Arg800Gly Single submitter ⚠
- p.Arg96Ser Single submitter ⚠
- p.Asn1162Ser Single submitter ⚠
- p.Asn1280Lys Single submitter ⚠
- p.Asn1377Ser Single submitter ⚠
- p.Asn375Ser Single submitter ⚠
- p.Asn386Ser Single submitter ⚠
- p.Asn548Ser Single submitter ⚠
- p.Asn619His Single submitter ⚠
- p.Asp1160Ala Single submitter ⚠
- p.Asp1379Glu Single submitter ⚠
- p.Asp1379Gly Single submitter ⚠
- p.Asp1414Glu Single submitter ⚠
- p.Asp646Asn Single submitter ⚠
- p.Asp69Glu Single submitter ⚠
- p.Cys1109Tyr Single submitter ⚠
- p.Cys1260Tyr Single submitter ⚠
- p.Cys525Tyr Single submitter ⚠
- p.Cys865Ser Single submitter ⚠
- p.Cys891Ser Single submitter ⚠
- p.Gln430Glu Single submitter ⚠
- p.Gln686Arg Single submitter ⚠
- p.Gln686Lys Single submitter ⚠
- p.Glu1292Ala Single submitter ⚠
- p.Glu1356Lys Single submitter ⚠
- p.Glu194Lys Single submitter ⚠
- p.Glu24Gln Single submitter ⚠
- p.Gly1357Glu Single submitter ⚠
- p.Gly447Glu Single submitter ⚠
- p.Gly693Ser Single submitter ⚠
- p.Gly728Glu Single submitter ⚠
- p.His1118Arg Single submitter ⚠
- p.His1329Gln Single submitter ⚠
- p.His1372Tyr Single submitter ⚠
- p.His837Asn Single submitter ⚠
- p.His989Arg Single submitter ⚠
- p.Ile1311Val Single submitter ⚠
- p.Ile1435Met Single submitter ⚠
- p.Ile15Thr Single submitter ⚠
- p.Ile15Val Single submitter ⚠
- p.Ile369Val Single submitter ⚠
- p.Ile421Val Single submitter ⚠
- p.Ile59Val Single submitter ⚠
- p.Ile613Thr Single submitter ⚠
- p.Ile672Thr Single submitter ⚠
- p.Ile758Thr Single submitter ⚠
- p.Ile916Met Single submitter ⚠
- p.Ile999Thr Single submitter ⚠
- p.Leu1112Phe Single submitter ⚠
- p.Leu1264Met Single submitter ⚠
- p.Leu1293Pro Single submitter ⚠
- p.Leu1337Ile Single submitter ⚠
- p.Leu417Val Single submitter ⚠
- p.Leu49Val Single submitter ⚠
- p.Leu507Phe Single submitter ⚠
- p.Leu533Met Single submitter ⚠
- p.Lys1022Thr Single submitter ⚠
- p.Lys1248Asn Single submitter ⚠
- p.Lys1287Gln Single submitter ⚠
- p.Lys518Glu Single submitter ⚠
- p.Met1020Val Single submitter ⚠
- p.Met1319Thr Single submitter ⚠
- p.Met1420Val Single submitter ⚠
- p.Met491Val Single submitter ⚠
- p.Met509Val Single submitter ⚠
- p.Met643Val Single submitter ⚠
- p.Met802Val Single submitter ⚠
- p.Met803Ile Single submitter ⚠
- p.Phe1156Val Single submitter ⚠
- p.Phe236Tyr Single submitter ⚠
- p.Phe302Tyr Single submitter ⚠
- p.Phe466Ser Single submitter ⚠
- p.Phe730Tyr Single submitter ⚠
- p.Phe899Leu Single submitter ⚠
- p.Phe901Ile Single submitter ⚠
- p.Phe924Leu Single submitter ⚠
- p.Phe925Ile Single submitter ⚠
- p.Pro1117Leu Single submitter ⚠
- p.Pro1235Leu Single submitter ⚠
- p.Pro1299Ser Single submitter ⚠
- p.Pro1324Arg Single submitter ⚠
- p.Pro1394Leu Single submitter ⚠
- p.Pro259Ala Single submitter ⚠
- p.Pro32Ala Single submitter ⚠
- p.Pro586Arg Single submitter ⚠
- p.Ser1031Cys Single submitter ⚠
- p.Ser1133Tyr Single submitter ⚠
- p.Ser1355Thr Single submitter ⚠
- p.Ser1380Cys Single submitter ⚠
- p.Ser393Pro Single submitter ⚠
- p.Ser3Phe Single submitter ⚠
- p.Ser423Leu Single submitter ⚠
- p.Ser511Pro Single submitter ⚠
- p.Ser634Ala Single submitter ⚠
- p.Ser881Asn Single submitter ⚠
- p.Ser881Gly Single submitter ⚠
- p.Thr1136Ser Single submitter ⚠
- p.Thr1294Met Single submitter ⚠
- p.Thr305Met Single submitter ⚠
- p.Thr428Ala Single submitter ⚠
- p.Thr456Ala Single submitter ⚠
- p.Thr822Ala Single submitter ⚠
- p.Thr822Met Single submitter ⚠
- p.Thr872Ile Single submitter ⚠
- p.Thr982Ala Single submitter ⚠
- p.Tyr1071His Single submitter ⚠
- p.Tyr1251His Single submitter ⚠
- p.Tyr1443Cys Single submitter ⚠
- p.Tyr182Cys Single submitter ⚠
- p.Tyr205His Single submitter ⚠
- p.Tyr346His Single submitter ⚠
- p.Tyr956Asn Single submitter ⚠
- p.Val1041Gly Single submitter ⚠
- p.Val1068Met Single submitter ⚠
- p.Val1255Leu Single submitter ⚠
- p.Val1255Met Single submitter ⚠
- p.Val383Met Single submitter ⚠
- p.Val404Ala Single submitter ⚠
- p.Val454Ala Single submitter ⚠
- p.Val567Met Single submitter ⚠
- p.Val678Leu Single submitter ⚠
- p.Val968Gly Single submitter ⚠
- p.Val971Phe Single submitter ⚠