Sugi Variant

Sugi Variant/ADGRV1

ADGRV1 — 7192 ClinVar variants

All ClinVar germline ADGRV1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1907 flagged for review →

395 Pathogenic · 89 Pathogenic/Likely pathogenic · 201 Likely pathogenic · 861 Conflicting · 366 Benign · 101 Benign/Likely benign · 2976 Likely benign · 2203 Uncertain significance

Full ADGRV1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 1907

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 9

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 493

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification. · showing the 150 best-reviewed of 493

Predictors lean, ClinVar uncertain 1298

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 1298

Predictors split 107

The independent predictors disagree with each other — read with care.

All ADGRV1 variants

Pathogenic 395

Showing the top 300 by review status; the full set is in the sitemap.

Pathogenic/Likely pathogenic 89

Likely pathogenic 201

Conflicting classifications of pathogenicity 861

Showing the top 300 by review status; the full set is in the sitemap.

Benign 366

Showing the top 300 by review status; the full set is in the sitemap.

Benign/Likely benign 101

Likely benign 2976

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 2203

Showing the top 300 by review status; the full set is in the sitemap.