ADH1A — 43 ClinVar variants
All ClinVar germline ADH1A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
1 Benign · 3 Likely benign · 39 Uncertain significance
Full ADH1A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADH1A p.Ala184Val Uncertain significance Single submitter
- ADH1A p.Asn156Ser Uncertain significance Single submitter
- ADH1A p.Asp298Gly Uncertain significance Single submitter
- ADH1A p.Cys101Phe Uncertain significance Single submitter
- ADH1A p.Cys112Tyr Uncertain significance Single submitter
- ADH1A p.Cys283Ser Uncertain significance Single submitter
- ADH1A p.Glu253Asp Uncertain significance Single submitter
- ADH1A p.Gly174Arg Uncertain significance Single submitter
- ADH1A p.Gly211Ser Uncertain significance Single submitter
- ADH1A p.Gly237Asp Uncertain significance Single submitter
- ADH1A p.Gly271Val Uncertain significance Single submitter
- ADH1A p.Gly366Glu Uncertain significance Single submitter
- ADH1A p.Lys105Gln Uncertain significance Single submitter
- ADH1A p.Lys136Thr Uncertain significance Single submitter
- ADH1A p.Met210Arg Uncertain significance Single submitter
- ADH1A p.Met374Ile Uncertain significance Single submitter
- ADH1A p.Pro107Leu Uncertain significance Single submitter
- ADH1A p.Pro297His Uncertain significance Single submitter
- ADH1A p.Ser266Thr Uncertain significance Single submitter
- ADH1A p.Ser55Gly Uncertain significance Single submitter
- ADH1A p.Thr123Asn Uncertain significance Single submitter
- ADH1A p.Val158Ile Uncertain significance Single submitter
- ADH1A p.Val185Leu Uncertain significance Single submitter
- ADH1A p.Val295Leu Uncertain significance Single submitter
- ADH1A p.Val37Ile Uncertain significance Single submitter
- ADH1A p.Val42Met Uncertain significance Single submitter
- ADH1A p.Val74Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- ADH1A p.Ala222Val Uncertain significance Single submitter
- ADH1A p.Asp50Glu Uncertain significance Single submitter
- ADH1A p.Cys241Tyr Uncertain significance Single submitter
- ADH1A p.Ile209Thr Uncertain significance Single submitter
- ADH1A p.Leu308Pro Uncertain significance Single submitter
- ADH1A p.Met337Thr Uncertain significance Single submitter
- ADH1A p.Phe267Leu Uncertain significance Single submitter
- ADH1A p.Ser129Arg Uncertain significance Single submitter
- ADH1A p.Thr82Ile Uncertain significance Single submitter
All ADH1A variants
Benign 1
- c.964+6T>C Multiple submitters
Likely benign 3
- p.Ala94Val Single submitter
- p.Ile95Val Single submitter
- p.Ser266= Single submitter
Uncertain significance 39
- p.Ala184Val Single submitter ⚠
- p.Ala222Val Single submitter ⚠
- p.Arg38His Single submitter
- p.Asn156Ser Single submitter ⚠
- p.Asp298Gly Single submitter ⚠
- p.Asp50Glu Single submitter ⚠
- p.Cys101Phe Single submitter ⚠
- p.Cys112Tyr Single submitter ⚠
- p.Cys241Tyr Single submitter ⚠
- p.Cys283Ser Single submitter ⚠
- p.Glu253Asp Single submitter ⚠
- p.Gly174Arg Single submitter ⚠
- p.Gly211Ser Single submitter ⚠
- p.Gly237Asp Single submitter ⚠
- p.Gly271Ser Single submitter
- p.Gly271Val Single submitter ⚠
- p.Gly366Glu Single submitter ⚠
- p.Gly72Ser Single submitter
- p.Ile209Thr Single submitter ⚠
- p.Leu308Pro Single submitter ⚠
- p.Lys105Gln Single submitter ⚠
- p.Lys136Thr Single submitter ⚠
- p.Met210Arg Single submitter ⚠
- p.Met337Thr Single submitter ⚠
- p.Met374Ile Single submitter ⚠
- p.Phe267Leu Single submitter ⚠
- p.Pro107Leu Single submitter ⚠
- p.Pro297His Single submitter ⚠
- p.Ser129Arg Single submitter ⚠
- p.Ser266Thr Single submitter ⚠
- p.Ser55Gly Single submitter ⚠
- p.Thr123Asn Single submitter ⚠
- p.Thr82Ile Single submitter ⚠
- p.Val158Ile Single submitter ⚠
- p.Val185Leu Single submitter ⚠
- p.Val295Leu Single submitter ⚠
- p.Val37Ile Single submitter ⚠
- p.Val42Met Single submitter ⚠
- p.Val74Met Single submitter ⚠