ADH1B — 63 ClinVar variants
All ClinVar germline ADH1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
7 Benign · 4 Likely benign · 52 Uncertain significance
Full ADH1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADH1B p.Ala164Ser Uncertain significance Single submitter
- ADH1B p.Ala345Val Uncertain significance Single submitter
- ADH1B p.Asn115Lys Uncertain significance Single submitter
- ADH1B p.Asn226Lys Uncertain significance Single submitter
- ADH1B p.Cys287Ser Uncertain significance Single submitter
- ADH1B p.Glu354Gln Uncertain significance Single submitter
- ADH1B p.Gly211Val Uncertain significance Single submitter
- ADH1B p.Ile173Val Uncertain significance Single submitter
- ADH1B p.Leu281Phe Uncertain significance Single submitter
- ADH1B p.Leu373Arg Uncertain significance Single submitter
- ADH1B p.Lys256Met Uncertain significance Single submitter
- ADH1B p.Lys367Asn Uncertain significance Single submitter
- ADH1B p.Met258Ile Uncertain significance Single submitter
- ADH1B p.Met307Val Uncertain significance Single submitter
- ADH1B p.Pro107Ala Uncertain significance Single submitter
- ADH1B p.Pro107Leu Uncertain significance Single submitter
- ADH1B p.Ser165Leu Uncertain significance Single submitter
- ADH1B p.Ser266Leu Uncertain significance Single submitter
- ADH1B p.Thr123Asn Uncertain significance Single submitter
- ADH1B p.Thr179Pro Uncertain significance Single submitter
- ADH1B p.Thr195Ile Uncertain significance Single submitter
- ADH1B p.Tyr150His Uncertain significance Single submitter
- ADH1B p.Val103Ile Uncertain significance Single submitter
- ADH1B p.Val291Ile Uncertain significance Single submitter
- ADH1B p.Val291Phe Uncertain significance Single submitter
- ADH1B p.Val42Ala Uncertain significance Single submitter
- ADH1B p.Val44Ala Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- ADH1B p.Ala222Val Uncertain significance Single submitter
- ADH1B p.Ala238Val Uncertain significance Single submitter
- ADH1B p.Arg134Ser Uncertain significance Single submitter
- ADH1B p.Asn357Lys Uncertain significance Single submitter
- ADH1B p.Gln300Pro Uncertain significance Single submitter
- ADH1B p.Glu358Lys Uncertain significance Single submitter
- ADH1B p.Gly193Ala Uncertain significance Single submitter
- ADH1B p.Ile138Thr Uncertain significance Single submitter
- ADH1B p.Ile65Thr Benign Single submitter
- ADH1B p.Leu172Phe Uncertain significance Single submitter
- ADH1B p.Lys213Asn Uncertain significance Single submitter
- ADH1B p.Lys324Asn Uncertain significance Single submitter
- ADH1B p.Lys340Glu Uncertain significance Single submitter
- ADH1B p.Met337Thr Uncertain significance Single submitter
- ADH1B p.Phe323Ser Uncertain significance Single submitter
- ADH1B p.Pro192Ser Uncertain significance Single submitter
- ADH1B p.Pro31Thr Uncertain significance Single submitter
- ADH1B p.Pro61Leu Uncertain significance Single submitter
- ADH1B p.Pro92Leu Uncertain significance Single submitter
- ADH1B p.Pro92Ser Uncertain significance Single submitter
- ADH1B p.Ser109Ile Uncertain significance Single submitter
- ADH1B p.Ser325Ile Uncertain significance Single submitter
- ADH1B p.Val293Ala Uncertain significance Single submitter
All ADH1B variants
Benign 7
- p.Ala222= Multiple submitters
- p.Ser165= Multiple submitters
- p.Trp16Arg Multiple submitters
- p.Val204= Multiple submitters
- c.1103+5A>G Single submitter
- c.121-3T>C Single submitter
- p.Ile65Thr Single submitter ⚠
Likely benign 4
- p.Asn186Lys Single submitter
- p.Cys287Tyr Single submitter
- p.Ser178= Single submitter
- p.Val209Ile Single submitter
Uncertain significance 52
- p.Ala164Ser Single submitter ⚠
- p.Ala222Val Single submitter ⚠
- p.Ala238Val Single submitter ⚠
- p.Ala345Val Single submitter ⚠
- p.Arg134Ser Single submitter ⚠
- p.Arg313His Single submitter
- p.Asn115Lys Single submitter ⚠
- p.Asn226Lys Single submitter ⚠
- p.Asn357Lys Single submitter ⚠
- p.Cys287Ser Single submitter ⚠
- p.Gln300Pro Single submitter ⚠
- p.Glu354Gln Single submitter ⚠
- p.Glu358Lys Single submitter ⚠
- p.Gly193Ala Single submitter ⚠
- p.Gly211Val Single submitter ⚠
- p.Ile138Thr Single submitter ⚠
- p.Ile161Thr Single submitter
- p.Ile173Val Single submitter ⚠
- p.Leu172Phe Single submitter ⚠
- p.Leu281Phe Single submitter ⚠
- p.Leu373Arg Single submitter ⚠
- p.Lys213Asn Single submitter ⚠
- p.Lys256Met Single submitter ⚠
- p.Lys324Asn Single submitter ⚠
- p.Lys340Glu Single submitter ⚠
- p.Lys367Asn Single submitter ⚠
- p.Met258Ile Single submitter ⚠
- p.Met307Val Single submitter ⚠
- p.Met337Thr Single submitter ⚠
- p.Phe323Ser Single submitter ⚠
- p.Pro107Ala Single submitter ⚠
- p.Pro107Leu Single submitter ⚠
- p.Pro192Ser Single submitter ⚠
- p.Pro250Leu Single submitter
- p.Pro31Thr Single submitter ⚠
- p.Pro61Leu Single submitter ⚠
- p.Pro92Leu Single submitter ⚠
- p.Pro92Ser Single submitter ⚠
- p.Ser109Ile Single submitter ⚠
- p.Ser165Leu Single submitter ⚠
- p.Ser266Leu Single submitter ⚠
- p.Ser325Ile Single submitter ⚠
- p.Thr123Asn Single submitter ⚠
- p.Thr179Pro Single submitter ⚠
- p.Thr195Ile Single submitter ⚠
- p.Tyr150His Single submitter ⚠
- p.Val103Ile Single submitter ⚠
- p.Val291Ile Single submitter ⚠
- p.Val291Phe Single submitter ⚠
- p.Val293Ala Single submitter ⚠
- p.Val42Ala Single submitter ⚠
- p.Val44Ala Single submitter ⚠