ADH4 — 51 ClinVar variants
All ClinVar germline ADH4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
51 Uncertain significance
Full ADH4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADH4 p.Ala188Val Uncertain significance Single submitter
- ADH4 p.Ala222Thr Uncertain significance Single submitter
- ADH4 p.Ala290Thr Uncertain significance Single submitter
- ADH4 p.Ala62Pro Uncertain significance Single submitter
- ADH4 p.Cys201Tyr Uncertain significance Single submitter
- ADH4 p.Gly179Arg Uncertain significance Single submitter
- ADH4 p.Gly179Val Uncertain significance Single submitter
- ADH4 p.His69Arg Uncertain significance Single submitter
- ADH4 p.Ile92Thr Uncertain significance Single submitter
- ADH4 p.Leu211Pro Uncertain significance Single submitter
- ADH4 p.Phe358Ser Uncertain significance Single submitter
- ADH4 p.Pro32Ala Uncertain significance Single submitter
- ADH4 p.Pro32Arg Uncertain significance Single submitter
- ADH4 p.Pro32His Uncertain significance Single submitter
- ADH4 p.Pro32Leu Uncertain significance Single submitter
- ADH4 p.Pro32Thr Uncertain significance Single submitter
- ADH4 p.Thr289Ile Uncertain significance Single submitter
- ADH4 p.Thr319Ser Uncertain significance Single submitter
- ADH4 p.Val67Ala Uncertain significance Single submitter
- ADH4 p.Val67Ile Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- ADH4 p.Ala15Thr Uncertain significance Single submitter
- ADH4 p.Ala72Val Uncertain significance Single submitter
- ADH4 p.Arg318Cys Uncertain significance Single submitter
- ADH4 p.Arg318Leu Uncertain significance Single submitter
- ADH4 p.Arg375Gln Uncertain significance Single submitter
- ADH4 p.Asn231Lys Uncertain significance Single submitter
- ADH4 p.Asn231Ser Uncertain significance Single submitter
- ADH4 p.Asn347Ser Uncertain significance Single submitter
- ADH4 p.Asp131Glu Uncertain significance Single submitter
- ADH4 p.Glu130Gly Uncertain significance Single submitter
- ADH4 p.Glu28Lys Uncertain significance Single submitter
- ADH4 p.Gly227Val Uncertain significance Single submitter
- ADH4 p.Gly306Glu Uncertain significance Single submitter
- ADH4 p.His35Pro Uncertain significance Single submitter
- ADH4 p.Ile261Thr Uncertain significance Single submitter
- ADH4 p.Ile298Thr Uncertain significance Single submitter
- ADH4 p.Leu348Gln Uncertain significance Single submitter
- ADH4 p.Lys132Thr Uncertain significance Single submitter
- ADH4 p.Lys33Arg Uncertain significance Single submitter
- ADH4 p.Lys33Glu Uncertain significance Single submitter
- ADH4 p.Phe146Leu Uncertain significance Single submitter
- ADH4 p.Phe235Leu Uncertain significance Single submitter
- ADH4 p.Pro21Ala Uncertain significance Single submitter
- ADH4 p.Pro87Arg Uncertain significance Single submitter
- ADH4 p.Pro97Arg Uncertain significance Single submitter
- ADH4 p.Ser199Leu Uncertain significance Single submitter
- ADH4 p.Thr151Ile Uncertain significance Single submitter
- ADH4 p.Val209Leu Uncertain significance Single submitter
- ADH4 p.Val214Ala Uncertain significance Single submitter
- ADH4 p.Val7Ile Uncertain significance Single submitter
- ADH4 p.Val85Ile Uncertain significance Single submitter
All ADH4 variants
Uncertain significance 51
- p.Ala15Thr Single submitter ⚠
- p.Ala188Val Single submitter ⚠
- p.Ala222Thr Single submitter ⚠
- p.Ala290Thr Single submitter ⚠
- p.Ala62Pro Single submitter ⚠
- p.Ala72Val Single submitter ⚠
- p.Arg318Cys Single submitter ⚠
- p.Arg318Leu Single submitter ⚠
- p.Arg375Gln Single submitter ⚠
- p.Asn231Lys Single submitter ⚠
- p.Asn231Ser Single submitter ⚠
- p.Asn347Ser Single submitter ⚠
- p.Asp131Glu Single submitter ⚠
- p.Cys201Tyr Single submitter ⚠
- p.Glu130Gly Single submitter ⚠
- p.Glu28Lys Single submitter ⚠
- p.Gly179Arg Single submitter ⚠
- p.Gly179Val Single submitter ⚠
- p.Gly227Val Single submitter ⚠
- p.Gly306Glu Single submitter ⚠
- p.His35Pro Single submitter ⚠
- p.His69Arg Single submitter ⚠
- p.Ile261Thr Single submitter ⚠
- p.Ile298Thr Single submitter ⚠
- p.Ile92Thr Single submitter ⚠
- p.Leu211Pro Single submitter ⚠
- p.Leu348Gln Single submitter ⚠
- p.Lys132Thr Single submitter ⚠
- p.Lys33Arg Single submitter ⚠
- p.Lys33Glu Single submitter ⚠
- p.Phe146Leu Single submitter ⚠
- p.Phe235Leu Single submitter ⚠
- p.Phe358Ser Single submitter ⚠
- p.Pro21Ala Single submitter ⚠
- p.Pro32Ala Single submitter ⚠
- p.Pro32Arg Single submitter ⚠
- p.Pro32His Single submitter ⚠
- p.Pro32Leu Single submitter ⚠
- p.Pro32Thr Single submitter ⚠
- p.Pro87Arg Single submitter ⚠
- p.Pro97Arg Single submitter ⚠
- p.Ser199Leu Single submitter ⚠
- p.Thr151Ile Single submitter ⚠
- p.Thr289Ile Single submitter ⚠
- p.Thr319Ser Single submitter ⚠
- p.Val209Leu Single submitter ⚠
- p.Val214Ala Single submitter ⚠
- p.Val67Ala Single submitter ⚠
- p.Val67Ile Single submitter ⚠
- p.Val7Ile Single submitter ⚠
- p.Val85Ile Single submitter ⚠