ADH6 — 50 ClinVar variants
All ClinVar germline ADH6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
3 Likely benign · 47 Uncertain significance
Full ADH6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADH6 p.Ala20Thr Uncertain significance Single submitter
- ADH6 p.Ala217Thr Uncertain significance Single submitter
- ADH6 p.Ala278Thr Uncertain significance Single submitter
- ADH6 p.Ala359Gly Uncertain significance Single submitter
- ADH6 p.Glu285Asp Uncertain significance Single submitter
- ADH6 p.Glu339Asp Uncertain significance Single submitter
- ADH6 p.Gly110Ser Uncertain significance Single submitter
- ADH6 p.Gly237Asp Uncertain significance Single submitter
- ADH6 p.Gly306Ser Uncertain significance Single submitter
- ADH6 p.Gly73Arg Uncertain significance Single submitter
- ADH6 p.His328Tyr Uncertain significance Single submitter
- ADH6 p.His58Tyr Uncertain significance Single submitter
- ADH6 p.Ile156Val Uncertain significance Single submitter
- ADH6 p.Ile92Thr Uncertain significance Single submitter
- ADH6 p.Lys367Gln Uncertain significance Single submitter
- ADH6 p.Pro345Ser Uncertain significance Single submitter
- ADH6 p.Ser104Phe Uncertain significance Single submitter
- ADH6 p.Thr121Ile Uncertain significance Single submitter
- ADH6 p.Thr239Ile Uncertain significance Single submitter
- ADH6 p.Val223Gly Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- ADH6 p.Ala159Val Uncertain significance Single submitter
- ADH6 p.Ala281Thr Uncertain significance Single submitter
- ADH6 p.Arg130Ser Uncertain significance Single submitter
- ADH6 p.Arg313Cys Uncertain significance Single submitter
- ADH6 p.Asn272His Uncertain significance Single submitter
- ADH6 p.Asn352Tyr Uncertain significance Single submitter
- ADH6 p.Asp89Asn Uncertain significance Single submitter
- ADH6 p.Cys196Arg Uncertain significance Single submitter
- ADH6 p.Cys368Arg Uncertain significance Single submitter
- ADH6 p.Gln98His Uncertain significance Single submitter
- ADH6 p.Glu361Lys Uncertain significance Single submitter
- ADH6 p.Gly142Arg Uncertain significance Single submitter
- ADH6 p.Ile161Thr Uncertain significance Single submitter
- ADH6 p.Ile221Val Uncertain significance Single submitter
- ADH6 p.Ile39Leu Uncertain significance Single submitter
- ADH6 p.Ile78Thr Uncertain significance Single submitter
- ADH6 p.Leu343Pro Uncertain significance Single submitter
- ADH6 p.Leu46Pro Uncertain significance Single submitter
- ADH6 p.Lys227Arg Uncertain significance Single submitter
- ADH6 p.Lys331Ile Uncertain significance Single submitter
- ADH6 p.Lys40Gln Uncertain significance Single submitter
- ADH6 p.Met210Thr Uncertain significance Single submitter
- ADH6 p.Met337Thr Uncertain significance Single submitter
- ADH6 p.Phe22Leu Uncertain significance Single submitter
- ADH6 p.Val360Ala Uncertain significance Single submitter
- ADH6 p.Val75Ile Uncertain significance Single submitter
- ADH6 p.Val7Phe Uncertain significance Single submitter
All ADH6 variants
Likely benign 3
- p.Gln234Lys Single submitter
- p.Glu168Asp Single submitter
- p.Leu273Pro Single submitter
Uncertain significance 47
- p.Ala159Val Single submitter ⚠
- p.Ala20Thr Single submitter ⚠
- p.Ala217Thr Single submitter ⚠
- p.Ala278Thr Single submitter ⚠
- p.Ala281Thr Single submitter ⚠
- p.Ala359Gly Single submitter ⚠
- p.Arg130Ser Single submitter ⚠
- p.Arg313Cys Single submitter ⚠
- p.Asn272His Single submitter ⚠
- p.Asn352Tyr Single submitter ⚠
- p.Asp89Asn Single submitter ⚠
- p.Cys196Arg Single submitter ⚠
- p.Cys368Arg Single submitter ⚠
- p.Gln98His Single submitter ⚠
- p.Glu285Asp Single submitter ⚠
- p.Glu339Asp Single submitter ⚠
- p.Glu361Lys Single submitter ⚠
- p.Gly110Ser Single submitter ⚠
- p.Gly142Arg Single submitter ⚠
- p.Gly237Asp Single submitter ⚠
- p.Gly306Ser Single submitter ⚠
- p.Gly73Arg Single submitter ⚠
- p.His328Tyr Single submitter ⚠
- p.His58Tyr Single submitter ⚠
- p.Ile156Val Single submitter ⚠
- p.Ile161Thr Single submitter ⚠
- p.Ile221Val Single submitter ⚠
- p.Ile39Leu Single submitter ⚠
- p.Ile78Thr Single submitter ⚠
- p.Ile92Thr Single submitter ⚠
- p.Leu343Pro Single submitter ⚠
- p.Leu46Pro Single submitter ⚠
- p.Lys227Arg Single submitter ⚠
- p.Lys331Ile Single submitter ⚠
- p.Lys367Gln Single submitter ⚠
- p.Lys40Gln Single submitter ⚠
- p.Met210Thr Single submitter ⚠
- p.Met337Thr Single submitter ⚠
- p.Phe22Leu Single submitter ⚠
- p.Pro345Ser Single submitter ⚠
- p.Ser104Phe Single submitter ⚠
- p.Thr121Ile Single submitter ⚠
- p.Thr239Ile Single submitter ⚠
- p.Val223Gly Single submitter ⚠
- p.Val360Ala Single submitter ⚠
- p.Val75Ile Single submitter ⚠
- p.Val7Phe Single submitter ⚠