ADH7 — 75 ClinVar variants
All ClinVar germline ADH7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
2 Benign · 9 Likely benign · 64 Uncertain significance
Full ADH7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADH7 c.-18A>T Uncertain significance Single submitter
- ADH7 c.-4C>G Uncertain significance Single submitter
- ADH7 p.Arg105Cys Uncertain significance Single submitter
- ADH7 p.Arg105His Uncertain significance Single submitter
- ADH7 p.Arg48His Uncertain significance Single submitter
- ADH7 p.Asp223Val Uncertain significance Single submitter
- ADH7 p.Asp326Asn Uncertain significance Single submitter
- ADH7 p.Cys174Tyr Uncertain significance Single submitter
- ADH7 p.Cys98Gly Uncertain significance Single submitter
- ADH7 p.Glu69Asp Uncertain significance Single submitter
- ADH7 p.Gly201Arg Uncertain significance Single submitter
- ADH7 p.Ile113Asn Uncertain significance Single submitter
- ADH7 p.Ile91Val Uncertain significance Single submitter
- ADH7 p.Leu93Pro Uncertain significance Single submitter
- ADH7 p.Lys228Gln Uncertain significance Single submitter
-
ADH7 p.Lys40Thr
Uncertain significance
Single submitter
ADH7-related disorder
- ADH7 p.Met257Ile Uncertain significance Single submitter
- ADH7 p.Ser297Pro Uncertain significance Single submitter
- ADH7 p.Ser367Gly Uncertain significance Single submitter
- ADH7 p.Thr145Arg Uncertain significance Single submitter
- ADH7 p.Thr310Ala Uncertain significance Single submitter
- ADH7 p.Tyr149His Uncertain significance Single submitter
- ADH7 p.Val197Ala Uncertain significance Single submitter
- ADH7 p.Val292Ile Uncertain significance Single submitter
- ADH7 p.Val332Met Uncertain significance Single submitter
- ADH7 p.Val66Met Uncertain significance Single submitter
- ADH7 p.Val74Glu Uncertain significance Single submitter
-
ADH7 p.Arg120Cys
Uncertain significance
No assertion criteria
ADH7-related disorder
Predictors split 38
The independent predictors disagree with each other — read with care.
- ADH7 p.Lys226Glu Benign Multiple submitters
- ADH7 p.Ala13Ser Uncertain significance Single submitter
- ADH7 p.Ala278Ser Uncertain significance Single submitter
- ADH7 p.Ala278Thr Uncertain significance Single submitter
- ADH7 p.Ala298Val Uncertain significance Single submitter
- ADH7 p.Arg312Cys Uncertain significance Single submitter
- ADH7 p.Asp153Gly Uncertain significance Single submitter
- ADH7 p.Asp326Gly Uncertain significance Single submitter
- ADH7 p.Cys317Trp Uncertain significance Single submitter
- ADH7 p.Gln20Glu Uncertain significance Single submitter
- ADH7 p.Glu239Val Uncertain significance Single submitter
- ADH7 p.Glu252Asp Uncertain significance Single submitter
- ADH7 p.Glu28Ala Uncertain significance Single submitter
- ADH7 p.Gly134Asp Uncertain significance Single submitter
- ADH7 p.Gly192Cys Uncertain significance Single submitter
- ADH7 p.Ile160Thr Uncertain significance Single submitter
- ADH7 p.Ile220Asn Uncertain significance Single submitter
- ADH7 p.Ile24Thr Uncertain significance Single submitter
- ADH7 p.Ile269Thr Uncertain significance Single submitter
- ADH7 p.Leu331Val Uncertain significance Single submitter
- ADH7 p.Lys159Arg Uncertain significance Single submitter
- ADH7 p.Lys168Arg Uncertain significance Single submitter
- ADH7 p.Lys338Asn Uncertain significance Single submitter
- ADH7 p.Met275Thr Uncertain significance Single submitter
- ADH7 p.Pro21His Uncertain significance Single submitter
- ADH7 p.Pro295His Uncertain significance Single submitter
- ADH7 p.Pro305Ala Uncertain significance Single submitter
- ADH7 p.Ser23Phe Uncertain significance Single submitter
- ADH7 p.Ser255Pro Uncertain significance Single submitter
- ADH7 p.Thr373Lys Uncertain significance Single submitter
- ADH7 p.Thr57Ala Likely benign Single submitter
- ADH7 p.Val169Leu Uncertain significance Single submitter
- ADH7 p.Val196Ile Uncertain significance Single submitter
- ADH7 p.Val196Leu Uncertain significance Single submitter
- ADH7 p.Val290Met Uncertain significance Single submitter
- ADH7 p.Val291Phe Uncertain significance Single submitter
- ADH7 p.Val66Gly Uncertain significance Single submitter
-
ADH7 p.Arg38His
Likely benign
No assertion criteria
ADH7-related disorder
All ADH7 variants
Benign 2
- p.Lys226Glu Multiple submitters ⚠
- c.121-6A>G No assertion criteria ADH7-related disorder
Likely benign 9
- p.His271Arg Single submitter
- p.Thr57Ala Single submitter ⚠
- c.120+7G>A No assertion criteria ADH7-related disorder
- c.-35T>C No assertion criteria ADH7-related disorder
- c.-4C>T No assertion criteria ADH7-related disorder
- p.Ala158= No assertion criteria ADH7-related disorder
- p.Arg120His No assertion criteria ADH7-related disorder
- p.Arg38His No assertion criteria ADH7-related disorder ⚠
- p.Lys33= No assertion criteria ADH7-related disorder
Uncertain significance 64
- c.-18A>T Single submitter ⚠
- c.-4C>G Single submitter ⚠
- p.Ala13Ser Single submitter ⚠
- p.Ala278Ser Single submitter ⚠
- p.Ala278Thr Single submitter ⚠
- p.Ala298Val Single submitter ⚠
- p.Arg105Cys Single submitter ⚠
- p.Arg105His Single submitter ⚠
- p.Arg312Cys Single submitter ⚠
- p.Arg48His Single submitter ⚠
- p.Asp153Gly Single submitter ⚠
- p.Asp223Val Single submitter ⚠
- p.Asp326Asn Single submitter ⚠
- p.Asp326Gly Single submitter ⚠
- p.Cys174Tyr Single submitter ⚠
- p.Cys317Trp Single submitter ⚠
- p.Cys98Gly Single submitter ⚠
- p.Gln20Glu Single submitter ⚠
- p.Glu239Val Single submitter ⚠
- p.Glu252Asp Single submitter ⚠
- p.Glu28Ala Single submitter ⚠
- p.Glu69Asp Single submitter ⚠
- p.Gly134Asp Single submitter ⚠
- p.Gly192Cys Single submitter ⚠
- p.Gly201Arg Single submitter ⚠
- p.Ile113Asn Single submitter ⚠
- p.Ile160Thr Single submitter ⚠
- p.Ile220Asn Single submitter ⚠
- p.Ile24Thr Single submitter ⚠
- p.Ile269Thr Single submitter ⚠
- p.Ile91Val Single submitter ⚠
- p.Leu331Val Single submitter ⚠
- p.Leu93Pro Single submitter ⚠
- p.Lys159Arg Single submitter ⚠
- p.Lys168Arg Single submitter ⚠
- p.Lys228Gln Single submitter ⚠
- p.Lys338Asn Single submitter ⚠
- p.Lys40Thr Single submitter ADH7-related disorder ⚠
- p.Met257Ile Single submitter ⚠
- p.Met275Thr Single submitter ⚠
- p.Pro21His Single submitter ⚠
- p.Pro295His Single submitter ⚠
- p.Pro305Ala Single submitter ⚠
- p.Ser23Phe Single submitter ⚠
- p.Ser255Pro Single submitter ⚠
- p.Ser297Pro Single submitter ⚠
- p.Ser367Gly Single submitter ⚠
- p.Thr145Arg Single submitter ⚠
- p.Thr310Ala Single submitter ⚠
- p.Thr373Lys Single submitter ⚠
- p.Tyr149His Single submitter ⚠
- p.Val169Leu Single submitter ⚠
- p.Val196Ile Single submitter ⚠
- p.Val196Leu Single submitter ⚠
- p.Val197Ala Single submitter ⚠
- p.Val290Met Single submitter ⚠
- p.Val291Phe Single submitter ⚠
- p.Val292Ile Single submitter ⚠
- p.Val332Met Single submitter ⚠
- p.Val66Gly Single submitter ⚠
- p.Val66Met Single submitter ⚠
- p.Val74Glu Single submitter ⚠
- p.Arg120Cys No assertion criteria ADH7-related disorder ⚠
- p.Thr186= No assertion criteria ADH7-related disorder