ADI1 — 30 ClinVar variants
All ClinVar germline ADI1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
3 Likely benign · 27 Uncertain significance
Full ADI1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADI1 p.Arg116Gly Uncertain significance Single submitter
- ADI1 p.Arg116Trp Uncertain significance Single submitter
- ADI1 p.Arg160Trp Uncertain significance Single submitter
- ADI1 p.Arg168His Uncertain significance Single submitter
- ADI1 p.Asn60Lys Uncertain significance Single submitter
- ADI1 p.Asp106Asn Uncertain significance Single submitter
- ADI1 p.Asp109Ala Uncertain significance Single submitter
- ADI1 p.Asp138Glu Uncertain significance Single submitter
- ADI1 p.Gln3Glu Uncertain significance Single submitter
- ADI1 p.Glu152Gln Uncertain significance Single submitter
- ADI1 p.Glu29Lys Uncertain significance Single submitter
- ADI1 p.Gly12Ser Uncertain significance Single submitter
- ADI1 p.Gly27Ala Uncertain significance Single submitter
- ADI1 p.Gly35Ala Uncertain significance Single submitter
- ADI1 p.Leu99Val Uncertain significance Single submitter
- ADI1 p.Met119Val Uncertain significance Single submitter
- ADI1 p.Met146Ile Uncertain significance Single submitter
- ADI1 p.Pro14Ala Uncertain significance Single submitter
- ADI1 p.Pro25Ser Uncertain significance Single submitter
- ADI1 p.Thr143Met Uncertain significance Single submitter
- ADI1 p.Thr178Ile Uncertain significance Single submitter
- ADI1 p.Trp5Cys Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All ADI1 variants
Likely benign 3
- p.Asp9Glu Single submitter
- p.Thr143Ala Single submitter
- p.Val172Met Single submitter
Uncertain significance 27
- p.Arg116Gly Single submitter ⚠
- p.Arg116Trp Single submitter ⚠
- p.Arg160Trp Single submitter ⚠
- p.Arg168His Single submitter ⚠
- p.Asn159Lys Single submitter
- p.Asn60Lys Single submitter ⚠
- p.Asp106Asn Single submitter ⚠
- p.Asp109Ala Single submitter ⚠
- p.Asp138Glu Single submitter ⚠
- p.Asp93Asn Single submitter
- p.Gln3Glu Single submitter ⚠
- p.Glu152Gln Single submitter ⚠
- p.Glu29Lys Single submitter ⚠
- p.Glu58Gln Single submitter ⚠
- p.Glu86Lys Single submitter ⚠
- p.Gly12Ser Single submitter ⚠
- p.Gly27Ala Single submitter ⚠
- p.Gly35Ala Single submitter ⚠
- p.Leu99Val Single submitter ⚠
- p.Met119Val Single submitter ⚠
- p.Met146Ile Single submitter ⚠
- p.Pro14Ala Single submitter ⚠
- p.Pro25Ser Single submitter ⚠
- p.Thr136Met Single submitter
- p.Thr143Met Single submitter ⚠
- p.Thr178Ile Single submitter ⚠
- p.Trp5Cys Single submitter ⚠