ADIG — 11 ClinVar variants
All ClinVar germline ADIG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
1 Likely benign · 10 Uncertain significance
Full ADIG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADIG p.Arg36His Uncertain significance Single submitter
- ADIG p.Arg77Lys Uncertain significance Single submitter
- ADIG p.Leu38Phe Uncertain significance Single submitter
- ADIG p.Leu39Phe Uncertain significance Single submitter
- ADIG p.Phe64Val Uncertain significance Single submitter
- ADIG p.Pro7Leu Uncertain significance Single submitter
- ADIG p.Ser49Arg Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All ADIG variants
Likely benign 1
- c.*351A>G Single submitter
Uncertain significance 10
- c.20C>A Single submitter
- p.Arg36His Single submitter ⚠
- p.Arg77Lys Single submitter ⚠
- p.Leu38Phe Single submitter ⚠
- p.Leu39Phe Single submitter ⚠
- p.Phe64Val Single submitter ⚠
- p.Pro24Ser Single submitter ⚠
- p.Pro7Leu Single submitter ⚠
- p.Ser49Arg Single submitter ⚠
- p.Thr13Lys Single submitter ⚠