ADIPOQ — 34 ClinVar variants
All ClinVar germline ADIPOQ variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
2 Pathogenic · 3 Benign · 7 Likely benign · 22 Uncertain significance
Full ADIPOQ gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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ADIPOQ p.Arg112Cys
Pathogenic
No assertion criteria
Adiponectin deficiency
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADIPOQ p.Asn244Ile Uncertain significance Single submitter
- ADIPOQ p.Asp179Asn Uncertain significance Single submitter
- ADIPOQ p.Asp229Glu Uncertain significance Single submitter
- ADIPOQ p.Glu120Asp Uncertain significance Single submitter
- ADIPOQ p.Gly105Arg Uncertain significance Single submitter
- ADIPOQ p.Gly118Val Uncertain significance Single submitter
- ADIPOQ p.Gly45Arg Uncertain significance Single submitter
- ADIPOQ p.Ile97Asn Uncertain significance Single submitter
- ADIPOQ p.Phe237Cys Uncertain significance Single submitter
- ADIPOQ p.Ser116Asn Uncertain significance Single submitter
- ADIPOQ p.Tyr109His Uncertain significance Single submitter
- ADIPOQ p.Tyr225Phe Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- ADIPOQ p.Gly38Asp Benign Multiple submitters
- ADIPOQ p.Asp70Asn Uncertain significance Single submitter
- ADIPOQ p.Glu64Gly Uncertain significance Single submitter
- ADIPOQ p.Gly34Arg Uncertain significance Single submitter
- ADIPOQ p.Leu183Phe Uncertain significance Single submitter
- ADIPOQ p.Lys65Arg Uncertain significance Single submitter
- ADIPOQ p.Pro86Leu Uncertain significance Single submitter
- ADIPOQ p.Pro95Leu Uncertain significance Single submitter
- ADIPOQ p.Val207Gly Uncertain significance Single submitter
All ADIPOQ variants
Pathogenic 2
- p.Arg112Cys No assertion criteria Adiponectin deficiency ⚠
- p.Gly93fs No assertion criteria Adiponectin deficiency
Benign 3
- p.Gly38Asp Multiple submitters ⚠
- p.Gly15= No assertion criteria ADIPOQ-related disorder
- p.Tyr111His No assertion criteria ADIPOQ-related disorder
Likely benign 7
- p.Gly90Ser Multiple submitters
- p.Arg221His Single submitter
- p.Leu11del Single submitter
- p.Thr83= Single submitter
- p.Gly96= No assertion criteria ADIPOQ-related disorder
- p.Leu175= No assertion criteria ADIPOQ-related disorder
- p.Pro91= No assertion criteria ADIPOQ-related disorder
Uncertain significance 22
- p.Asn244Ile Single submitter ⚠
- p.Asp179Asn Single submitter ⚠
- p.Asp229Glu Single submitter ⚠
- p.Asp70Asn Single submitter ⚠
- p.Glu120Asp Single submitter ⚠
- p.Glu220Ter Single submitter
- p.Glu64Gly Single submitter ⚠
- p.Gly105Arg Single submitter ⚠
- p.Gly118Val Single submitter ⚠
- p.Gly15fs Single submitter
- p.Gly34Arg Single submitter ⚠
- p.Gly45Arg Single submitter ⚠
- p.Ile97Asn Single submitter ⚠
- p.Leu183Phe Single submitter ⚠
- p.Lys65Arg Single submitter ⚠
- p.Phe237Cys Single submitter ⚠
- p.Pro86Leu Single submitter ⚠
- p.Pro95Leu Single submitter ⚠
- p.Ser116Asn Single submitter ⚠
- p.Tyr109His Single submitter ⚠
- p.Tyr225Phe Single submitter ⚠
- p.Val207Gly Single submitter ⚠