ADIPOR2 — 18 ClinVar variants
All ClinVar germline ADIPOR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
1 Benign · 2 Likely benign · 15 Uncertain significance
Full ADIPOR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADIPOR2 p.Ala325Thr Uncertain significance Single submitter
- ADIPOR2 p.Arg31Gln Uncertain significance Single submitter
- ADIPOR2 p.Arg373His Uncertain significance Single submitter
- ADIPOR2 p.Arg8Gln Uncertain significance Single submitter
- ADIPOR2 p.Gly286Arg Uncertain significance Single submitter
- ADIPOR2 p.His62Pro Uncertain significance Single submitter
- ADIPOR2 p.His86Arg Uncertain significance Single submitter
- ADIPOR2 p.Ile106Phe Uncertain significance Single submitter
- ADIPOR2 p.Ile291Asn Uncertain significance Single submitter
- ADIPOR2 p.Met167Val Uncertain significance Single submitter
- ADIPOR2 p.Met268Thr Uncertain significance Single submitter
- ADIPOR2 p.Met91Val Uncertain significance Single submitter
- ADIPOR2 p.Thr293Ala Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All ADIPOR2 variants
Benign 1
- p.Gly377= Single submitter
Likely benign 2
- c.651-10dup No assertion criteria ADIPOR2-related disorder
- c.-2C>T No assertion criteria ADIPOR2-related disorder
Uncertain significance 15
- p.Ala259Val Single submitter ⚠
- p.Ala325Thr Single submitter ⚠
- p.Arg31Gln Single submitter ⚠
- p.Arg373His Single submitter ⚠
- p.Arg8Gln Single submitter ⚠
- p.Gly286Arg Single submitter ⚠
- p.His62Pro Single submitter ⚠
- p.His86Arg Single submitter ⚠
- p.Ile106Phe Single submitter ⚠
- p.Ile291Asn Single submitter ⚠
- p.Met167Val Single submitter ⚠
- p.Met268Thr Single submitter ⚠
- p.Met91Val Single submitter ⚠
- p.Pro80Ser Single submitter ⚠
- p.Thr293Ala Single submitter ⚠