ADM — 26 ClinVar variants
All ClinVar germline ADM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
2 Benign · 3 Likely benign · 21 Uncertain significance
Full ADM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADM p.Ala22Ser Uncertain significance Single submitter
- ADM p.Ala38Ser Uncertain significance Single submitter
- ADM p.Ala38Val Uncertain significance Single submitter
- ADM p.Ala87Val Uncertain significance Single submitter
- ADM p.Arg89His Uncertain significance Single submitter
- ADM p.Arg94Leu Uncertain significance Single submitter
- ADM p.Asn35Lys Uncertain significance Single submitter
- ADM p.Gln144Glu Uncertain significance Single submitter
- ADM p.Leu185Val Uncertain significance Single submitter
- ADM p.Met73Arg Uncertain significance Single submitter
- ADM p.Pro174Ser Uncertain significance Single submitter
- ADM p.Pro177Ala Uncertain significance Single submitter
- ADM p.Ser98Thr Uncertain significance Single submitter
- ADM p.Thr162Ser Uncertain significance Single submitter
- ADM p.Tyr10Phe Uncertain significance Single submitter
- ADM p.Val4Asp Uncertain significance Single submitter
- ADM p.Val4Leu Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All ADM variants
Benign 2
- p.Ser50Arg Multiple submitters
- p.Pro85Arg Single submitter
Likely benign 3
- p.Leu3= Single submitter
- p.Pro159= Single submitter
- p.Ser139Asn Single submitter
Uncertain significance 21
- p.Ala22Ser Single submitter ⚠
- p.Ala38Ser Single submitter ⚠
- p.Ala38Val Single submitter ⚠
- p.Ala87Val Single submitter ⚠
- p.Arg23Trp Single submitter ⚠
- p.Arg89His Single submitter ⚠
- p.Arg94Leu Single submitter ⚠
- p.Arg96Gly Single submitter ⚠
- p.Asn35Lys Single submitter ⚠
- p.Gln123His Single submitter ⚠
- p.Gln144Glu Single submitter ⚠
- p.Leu185Val Single submitter ⚠
- p.Met73Arg Single submitter ⚠
- p.Pro174Ser Single submitter ⚠
- p.Pro177Ala Single submitter ⚠
- p.Ser79Asn Single submitter ⚠
- p.Ser98Thr Single submitter ⚠
- p.Thr162Ser Single submitter ⚠
- p.Tyr10Phe Single submitter ⚠
- p.Val4Asp Single submitter ⚠
- p.Val4Leu Single submitter ⚠