ADM2 — 25 ClinVar variants
All ClinVar germline ADM2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
1 Benign · 3 Likely benign · 21 Uncertain significance
Full ADM2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADM2 p.Ala54Thr Uncertain significance Single submitter
- ADM2 p.Ala75Val Uncertain significance Single submitter
- ADM2 p.Arg133Gln Uncertain significance Single submitter
- ADM2 p.Arg56Gln Uncertain significance Single submitter
- ADM2 p.Arg87His Uncertain significance Single submitter
- ADM2 p.Gly132Ser Uncertain significance Single submitter
- ADM2 p.Gly73Ala Uncertain significance Single submitter
- ADM2 p.His95Pro Uncertain significance Single submitter
- ADM2 p.Leu62Pro Uncertain significance Single submitter
- ADM2 p.Pro57Ser Uncertain significance Single submitter
- ADM2 p.Ser121Thr Uncertain significance Single submitter
- ADM2 p.Ser136Leu Uncertain significance Single submitter
- ADM2 p.Ser90Leu Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ADM2 p.Arg107Gly Uncertain significance Single submitter
- ADM2 p.Arg42Trp Uncertain significance Single submitter
- ADM2 p.Arg93Pro Uncertain significance Single submitter
- ADM2 p.Arg99His Uncertain significance Single submitter
- ADM2 p.Gly113Asp Uncertain significance Single submitter
- ADM2 p.His145Gln Uncertain significance Single submitter
- ADM2 p.Leu105Phe Uncertain significance Single submitter
- ADM2 p.Leu82Phe Uncertain significance Single submitter
All ADM2 variants
Benign 1
- p.Arg83= Multiple submitters
Likely benign 3
- p.Arg64Gln Single submitter
- p.Ser43Thr Single submitter
- p.Val77Ala Single submitter
Uncertain significance 21
- p.Ala54Thr Single submitter ⚠
- p.Ala75Val Single submitter ⚠
- p.Arg107Gly Single submitter ⚠
- p.Arg133Gln Single submitter ⚠
- p.Arg42Trp Single submitter ⚠
- p.Arg56Gln Single submitter ⚠
- p.Arg87His Single submitter ⚠
- p.Arg93Pro Single submitter ⚠
- p.Arg99His Single submitter ⚠
- p.Gly113Asp Single submitter ⚠
- p.Gly132Ser Single submitter ⚠
- p.Gly73Ala Single submitter ⚠
- p.His145Gln Single submitter ⚠
- p.His95Pro Single submitter ⚠
- p.Leu105Phe Single submitter ⚠
- p.Leu62Pro Single submitter ⚠
- p.Leu82Phe Single submitter ⚠
- p.Pro57Ser Single submitter ⚠
- p.Ser121Thr Single submitter ⚠
- p.Ser136Leu Single submitter ⚠
- p.Ser90Leu Single submitter ⚠