ADM5 — 33 ClinVar variants
All ClinVar germline ADM5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
1 Likely benign · 32 Uncertain significance
Full ADM5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADM5 p.Ala102Gly Uncertain significance Single submitter
- ADM5 p.Ala114Val Uncertain significance Single submitter
- ADM5 p.Ala13Val Uncertain significance Single submitter
- ADM5 p.Ala16Ser Uncertain significance Single submitter
- ADM5 p.Ala71Gly Uncertain significance Single submitter
- ADM5 p.Ala98Gly Uncertain significance Single submitter
- ADM5 p.Arg35His Uncertain significance Single submitter
- ADM5 p.Arg90Gln Uncertain significance Single submitter
- ADM5 p.Arg90Leu Uncertain significance Single submitter
- ADM5 p.Asp153Asn Uncertain significance Single submitter
- ADM5 p.Glu51Asp Uncertain significance Single submitter
- ADM5 p.Gly112Ala Uncertain significance Single submitter
- ADM5 p.Gly151Arg Uncertain significance Single submitter
- ADM5 p.Gly27Asp Uncertain significance Single submitter
- ADM5 p.Gly86Arg Uncertain significance Single submitter
- ADM5 p.His132Tyr Uncertain significance Single submitter
- ADM5 p.Ile133Phe Uncertain significance Single submitter
- ADM5 p.Ile53Thr Uncertain significance Single submitter
- ADM5 p.Ile5Asn Uncertain significance Single submitter
- ADM5 p.Leu129Arg Uncertain significance Single submitter
- ADM5 p.Leu41Arg Uncertain significance Single submitter
- ADM5 p.Pro105Ser Uncertain significance Single submitter
- ADM5 p.Pro136Ser Uncertain significance Single submitter
- ADM5 p.Pro32Leu Uncertain significance Single submitter
- ADM5 p.Ser111Leu Uncertain significance Single submitter
- ADM5 p.Thr143Ser Uncertain significance Single submitter
- ADM5 p.Trp78Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All ADM5 variants
Likely benign 1
- p.Arg45Gln Single submitter
Uncertain significance 32
- p.Ala102Gly Single submitter ⚠
- p.Ala114Val Single submitter ⚠
- p.Ala13Val Single submitter ⚠
- p.Ala16Ser Single submitter ⚠
- p.Ala71Gly Single submitter ⚠
- p.Ala98Gly Single submitter ⚠
- p.Arg35His Single submitter ⚠
- p.Arg90Gln Single submitter ⚠
- p.Arg90Leu Single submitter ⚠
- p.Arg90Trp Single submitter ⚠
- p.Asp153Asn Single submitter ⚠
- p.Glu51Asp Single submitter ⚠
- p.Gly112Ala Single submitter ⚠
- p.Gly151Arg Single submitter ⚠
- p.Gly27Asp Single submitter ⚠
- p.Gly86Arg Single submitter ⚠
- p.His132Tyr Single submitter ⚠
- p.Ile133Phe Single submitter ⚠
- p.Ile53Met Single submitter ⚠
- p.Ile53Thr Single submitter ⚠
- p.Ile56Thr Single submitter ⚠
- p.Ile5Asn Single submitter ⚠
- p.Leu129Arg Single submitter ⚠
- p.Leu41Arg Single submitter ⚠
- p.Pro105Ser Single submitter ⚠
- p.Pro136Ser Single submitter ⚠
- p.Pro148Thr Single submitter ⚠
- p.Pro32Leu Single submitter ⚠
- p.Ser111Leu Single submitter ⚠
- p.Thr143Ser Single submitter ⚠
- p.Trp108Cys Single submitter ⚠
- p.Trp78Leu Single submitter ⚠