ADORA1 — 47 ClinVar variants
All ClinVar germline ADORA1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
2 Conflicting · 3 Benign · 8 Likely benign · 34 Uncertain significance
Full ADORA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 2
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADORA1 p.Ala155Asp Uncertain significance Single submitter
- ADORA1 p.Ala155Thr Uncertain significance Single submitter
- ADORA1 p.Ala158Ser Uncertain significance Single submitter
- ADORA1 p.Ala312Val Uncertain significance Single submitter
- ADORA1 p.Arg308Cys Uncertain significance Single submitter
- ADORA1 p.Asn159Ser Uncertain significance Single submitter
- ADORA1 p.Asn212Asp Uncertain significance Single submitter
- ADORA1 p.Cys309Gly Uncertain significance Single submitter
- ADORA1 p.Glu202Asp Uncertain significance Single submitter
- ADORA1 p.Glu317Lys Uncertain significance Single submitter
- ADORA1 p.Gly130Ser Uncertain significance Single submitter
- ADORA1 p.Gly220Ser Uncertain significance Single submitter
- ADORA1 p.Ile5Val Uncertain significance Single submitter
- ADORA1 p.Ile71Thr Uncertain significance Single submitter
- ADORA1 p.Leu258Phe Uncertain significance Single submitter
- ADORA1 p.Leu319Phe Uncertain significance Single submitter
- ADORA1 p.Lys110Arg Uncertain significance Single submitter
- ADORA1 p.Lys168Thr Uncertain significance Single submitter
- ADORA1 p.Met143Val Uncertain significance Single submitter
- ADORA1 p.Pro222Leu Uncertain significance Single submitter
- ADORA1 p.Ser161Thr Uncertain significance Single submitter
- ADORA1 p.Val137Met Uncertain significance Single submitter
- ADORA1 p.Val203Ile Uncertain significance Single submitter
- ADORA1 p.Val297Ile Uncertain significance Single submitter
- ADORA1 p.Gly279Ser Uncertain significance No assertion criteria
Predictors split 8
The independent predictors disagree with each other — read with care.
- ADORA1 p.Ala233Thr Uncertain significance Single submitter
- ADORA1 p.Arg154Trp Uncertain significance Single submitter
- ADORA1 p.Arg208Cys Uncertain significance Single submitter
- ADORA1 p.Gly160Ser Uncertain significance Single submitter
- ADORA1 p.Leu81Phe Uncertain significance Single submitter
- ADORA1 p.Met143Thr Uncertain significance Single submitter
- ADORA1 p.Pro165Ser Uncertain significance Single submitter
- ADORA1 p.Val56Gly Uncertain significance Single submitter
All ADORA1 variants
Conflicting classifications of pathogenicity 2
- p.Ala125Val Single submitter ⚠
- p.Val53Met Single submitter ⚠
Likely benign 8
- c.342-4C>G Single submitter
- p.Ala39= Single submitter
- p.Arg154Gln Single submitter
- p.Asn212Ser Single submitter
- p.Met162Val Single submitter
- p.Phe171= Single submitter
- p.Thr277= Single submitter
- c.342-23C>T No assertion criteria ADORA1-related disorder
Uncertain significance 34
- p.Ala155Asp Single submitter ⚠
- p.Ala155Thr Single submitter ⚠
- p.Ala158Ser Single submitter ⚠
- p.Ala233Thr Single submitter ⚠
- p.Ala312Val Single submitter ⚠
- p.Arg154Trp Single submitter ⚠
- p.Arg208Cys Single submitter ⚠
- p.Arg308Cys Single submitter ⚠
- p.Asn159Ser Single submitter ⚠
- p.Asn212Asp Single submitter ⚠
- p.Cys309Gly Single submitter ⚠
- p.Glu202Asp Single submitter ⚠
- p.Glu317Lys Single submitter ⚠
- p.Gly130Ser Single submitter ⚠
- p.Gly160Ser Single submitter ⚠
- p.Gly220Ser Single submitter ⚠
- p.Ile5Val Single submitter ⚠
- p.Ile71Thr Single submitter ⚠
- p.Leu258Phe Single submitter ⚠
- p.Leu319Phe Single submitter ⚠
- p.Leu65Phe Single submitter
- p.Leu81Phe Single submitter ⚠
- p.Lys110Arg Single submitter ⚠
- p.Lys168Thr Single submitter ⚠
- p.Met143Thr Single submitter ⚠
- p.Met143Val Single submitter ⚠
- p.Pro165Ser Single submitter ⚠
- p.Pro222Leu Single submitter ⚠
- p.Ser161Thr Single submitter ⚠
- p.Val137Met Single submitter ⚠
- p.Val203Ile Single submitter ⚠
- p.Val297Ile Single submitter ⚠
- p.Val56Gly Single submitter ⚠
- p.Gly279Ser No assertion criteria ⚠