ADORA2A — 51 ClinVar variants
All ClinVar germline ADORA2A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
5 Benign · 3 Likely benign · 43 Uncertain significance
Full ADORA2A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADORA2A p.Ala165Ser Uncertain significance Single submitter
- ADORA2A p.Ala50Ser Uncertain significance Single submitter
- ADORA2A p.Arg199Trp Uncertain significance Single submitter
- ADORA2A p.Arg205Gln Uncertain significance Single submitter
- ADORA2A p.Arg296Leu Uncertain significance Single submitter
- ADORA2A p.Arg304His Uncertain significance Single submitter
- ADORA2A p.Arg322Gln Uncertain significance Single submitter
- ADORA2A p.Asp402Asn Uncertain significance Single submitter
- ADORA2A p.Gln148Arg Uncertain significance Single submitter
- ADORA2A p.Gly118Ser Uncertain significance Single submitter
- ADORA2A p.Gly142Ser Uncertain significance Single submitter
- ADORA2A p.Gly152Ser Uncertain significance Single submitter
- ADORA2A p.Gly160Arg Uncertain significance Single submitter
- ADORA2A p.Gly318Ser Uncertain significance Single submitter
- ADORA2A p.Gly340Ser Uncertain significance Single submitter
- ADORA2A p.Gly364Val Uncertain significance Single submitter
- ADORA2A p.Gly410Ala Uncertain significance Single submitter
- ADORA2A p.His306Arg Uncertain significance Single submitter
- ADORA2A p.His388Tyr Uncertain significance Single submitter
- ADORA2A p.Ile251Phe Uncertain significance Single submitter
- ADORA2A p.Leu131Val Uncertain significance Single submitter
- ADORA2A p.Leu324Ser Uncertain significance Single submitter
- ADORA2A p.Leu390Pro Uncertain significance Single submitter
- ADORA2A p.Met4Thr Uncertain significance Single submitter
- ADORA2A p.Pro358Ser Uncertain significance Single submitter
- ADORA2A p.Ser320Gly Uncertain significance Single submitter
- ADORA2A p.Ser329Asn Uncertain significance Single submitter
- ADORA2A p.Ser367Asn Uncertain significance Single submitter
- ADORA2A p.Ser412Phe Uncertain significance Single submitter
- ADORA2A p.Ser7Leu Uncertain significance Single submitter
- ADORA2A p.Thr119Met Uncertain significance Single submitter
- ADORA2A p.Thr68Ile Uncertain significance Single submitter
- ADORA2A p.Trp346Arg Uncertain significance Single submitter
- ADORA2A p.Tyr290Phe Uncertain significance Single submitter
- ADORA2A p.Val345Leu Uncertain significance Single submitter
- ADORA2A p.Val345Met Uncertain significance Single submitter
- ADORA2A p.Val8Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All ADORA2A variants
Benign 5
- p.Asn144= Multiple submitters
- p.Asn348= Multiple submitters
- p.Gly147Ser Multiple submitters
- p.Ile237= Multiple submitters
- p.Phe295= Multiple submitters
Likely benign 3
- c.332+9G>A Single submitter
- p.Thr11= Single submitter
- p.Val307Ile Single submitter
Uncertain significance 43
- p.Ala165Ser Single submitter ⚠
- p.Ala50Ser Single submitter ⚠
- p.Arg107Ser Single submitter ⚠
- p.Arg199Trp Single submitter ⚠
- p.Arg205Gln Single submitter ⚠
- p.Arg291Cys Single submitter ⚠
- p.Arg296His Single submitter ⚠
- p.Arg296Leu Single submitter ⚠
- p.Arg304His Single submitter ⚠
- p.Arg322Gln Single submitter ⚠
- p.Asp402Asn Single submitter ⚠
- p.Gln148Arg Single submitter ⚠
- p.Gly118Ser Single submitter ⚠
- p.Gly142Ser Single submitter ⚠
- p.Gly152Ser Single submitter ⚠
- p.Gly160Arg Single submitter ⚠
- p.Gly318Ser Single submitter ⚠
- p.Gly340Ser Single submitter ⚠
- p.Gly364Val Single submitter ⚠
- p.Gly410Ala Single submitter ⚠
- p.His306Arg Single submitter ⚠
- p.His388Tyr Single submitter ⚠
- p.Ile251Phe Single submitter ⚠
- p.Leu131Val Single submitter ⚠
- p.Leu308Pro Single submitter
- p.Leu324Ser Single submitter ⚠
- p.Leu390Pro Single submitter ⚠
- p.Met4Thr Single submitter ⚠
- p.Pro358Ser Single submitter ⚠
- p.Ser320Gly Single submitter ⚠
- p.Ser329Asn Single submitter ⚠
- p.Ser367Asn Single submitter ⚠
- p.Ser412Phe Single submitter ⚠
- p.Ser7Leu Single submitter ⚠
- p.Thr119Met Single submitter ⚠
- p.Thr68Ile Single submitter ⚠
- p.Trp346Arg Single submitter ⚠
- p.Tyr290Phe Single submitter ⚠
- p.Val196Ala Single submitter ⚠
- p.Val345Leu Single submitter ⚠
- p.Val345Met Single submitter ⚠
- p.Val46Ala Single submitter ⚠
- p.Val8Ala Single submitter ⚠