ADORA2B — 52 ClinVar variants
All ClinVar germline ADORA2B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
4 Benign · 48 Uncertain significance
Full ADORA2B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADORA2B p.Ala244Val Uncertain significance Single submitter
- ADORA2B p.Ala275Gly Uncertain significance Single submitter
- ADORA2B p.Ala35Gly Uncertain significance Single submitter
- ADORA2B p.Ala8Glu Uncertain significance Single submitter
- ADORA2B p.Arg121Leu Uncertain significance Single submitter
- ADORA2B p.Arg215Gly Uncertain significance Single submitter
- ADORA2B p.Arg295Gln Uncertain significance Single submitter
- ADORA2B p.Arg298Leu Uncertain significance Single submitter
- ADORA2B p.Asn145Lys Uncertain significance Single submitter
- ADORA2B p.Asn43Thr Uncertain significance Single submitter
- ADORA2B p.Cys190Gly Uncertain significance Single submitter
- ADORA2B p.Gln260Arg Uncertain significance Single submitter
- ADORA2B p.Gln6Lys Uncertain significance Single submitter
- ADORA2B p.Glu164Gly Uncertain significance Single submitter
- ADORA2B p.Gly137Arg Uncertain significance Single submitter
- ADORA2B p.Gly24Asp Uncertain significance Single submitter
- ADORA2B p.Gly323Glu Uncertain significance Single submitter
- ADORA2B p.Gly329Ser Uncertain significance Single submitter
- ADORA2B p.Ile197Leu Uncertain significance Single submitter
- ADORA2B p.Ile203Met Uncertain significance Single submitter
- ADORA2B p.Leu258Phe Uncertain significance Single submitter
- ADORA2B p.Leu277Arg Uncertain significance Single submitter
- ADORA2B p.Leu310Phe Uncertain significance Single submitter
- ADORA2B p.Leu328Val Uncertain significance Single submitter
- ADORA2B p.Lys114Gln Uncertain significance Single submitter
- ADORA2B p.Lys170Asn Uncertain significance Single submitter
- ADORA2B p.Met179Val Uncertain significance Single submitter
- ADORA2B p.Pro193Ser Uncertain significance Single submitter
- ADORA2B p.Pro249Arg Uncertain significance Single submitter
- ADORA2B p.Pro249Ser Uncertain significance Single submitter
- ADORA2B p.Ser149Arg Uncertain significance Single submitter
- ADORA2B p.Thr162Met Uncertain significance Single submitter
- ADORA2B p.Thr42Ile Uncertain significance Single submitter
- ADORA2B p.Thr66Ile Uncertain significance Single submitter
- ADORA2B p.Tyr202Phe Uncertain significance Single submitter
- ADORA2B p.Val22Leu Uncertain significance Single submitter
- ADORA2B p.Val256Ile Uncertain significance Single submitter
- ADORA2B p.Val47Gly Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ADORA2B p.Ala8Pro Uncertain significance Single submitter
- ADORA2B p.Asn282Ser Uncertain significance Single submitter
- ADORA2B p.Cys108Tyr Uncertain significance Single submitter
- ADORA2B p.Leu9Pro Uncertain significance Single submitter
- ADORA2B p.Phe94Leu Uncertain significance Single submitter
- ADORA2B p.Ser91Asn Uncertain significance Single submitter
- ADORA2B p.Thr40Ala Uncertain significance Single submitter
- ADORA2B p.Val85Leu Uncertain significance Single submitter
All ADORA2B variants
Benign 4
- p.Ala262= Multiple submitters
- p.Ala35Val Multiple submitters
- p.Thr37= Multiple submitters
- p.Thr118= Single submitter
Uncertain significance 48
- p.Ala244Val Single submitter ⚠
- p.Ala275Gly Single submitter ⚠
- p.Ala35Gly Single submitter ⚠
- p.Ala8Glu Single submitter ⚠
- p.Ala8Pro Single submitter ⚠
- p.Arg121Leu Single submitter ⚠
- p.Arg215Gly Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg298His Single submitter
- p.Arg298Leu Single submitter ⚠
- p.Asn145Lys Single submitter ⚠
- p.Asn282Ser Single submitter ⚠
- p.Asn43Thr Single submitter ⚠
- p.Cys108Tyr Single submitter ⚠
- p.Cys190Gly Single submitter ⚠
- p.Gln260Arg Single submitter ⚠
- p.Gln6Lys Single submitter ⚠
- p.Glu164Gly Single submitter ⚠
- p.Gly137Arg Single submitter ⚠
- p.Gly24Asp Single submitter ⚠
- p.Gly323Glu Single submitter ⚠
- p.Gly329Ser Single submitter ⚠
- p.Ile197Leu Single submitter ⚠
- p.Ile203Met Single submitter ⚠
- p.Leu236Val Single submitter
- p.Leu258Phe Single submitter ⚠
- p.Leu277Arg Single submitter ⚠
- p.Leu310Phe Single submitter ⚠
- p.Leu328Val Single submitter ⚠
- p.Leu9Pro Single submitter ⚠
- p.Lys114Gln Single submitter ⚠
- p.Lys170Asn Single submitter ⚠
- p.Met179Val Single submitter ⚠
- p.Phe94Leu Single submitter ⚠
- p.Pro193Ser Single submitter ⚠
- p.Pro249Arg Single submitter ⚠
- p.Pro249Ser Single submitter ⚠
- p.Ser149Arg Single submitter ⚠
- p.Ser91Asn Single submitter ⚠
- p.Thr162Met Single submitter ⚠
- p.Thr40Ala Single submitter ⚠
- p.Thr42Ile Single submitter ⚠
- p.Thr66Ile Single submitter ⚠
- p.Tyr202Phe Single submitter ⚠
- p.Val22Leu Single submitter ⚠
- p.Val256Ile Single submitter ⚠
- p.Val47Gly Single submitter ⚠
- p.Val85Leu Single submitter ⚠